<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32593

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMIPNSSAGGQSWGHPLRNVDNDTARGDTSQAFNRPDIRSEGQQYTPALPRHPGQPAVIDLTSSANDAQEGQPPAKRLKLDITAESSANPASPTPATTGDSRVTPGIANSKPSALSWRGRPVWSFQAMISEVMSGAEATEEDAILAPQGKRPASPPPFPQPSWKGAPPEQFGSNATKASESDSSKKVQTTPFRVEVPSIAPALKGDKVADFAPWIGNHPEDILSEQTVKQGHYDRTQVSQNESNTARPSLYAQLKHRSGLQMLSSVFMAALEKRQNHNTINVPSNFKPPPRVTLTDNKREAWLRDLANPSVPLRRLSRTIPHGIRGKNLLDQCLSKWIPVNRAVWLVKCVGANEIRACKRKGTGGTLVVGSEVKWVRDWTSGVQQFLEGVIGACGSADWKSKMTYATSLTARLFFERLLDHDQYFAWFLTSLEGASLNMVPVWLLMLGIYWDSMLRYRKRGRRLAEVLLGKLHQTTELQRPTLLQPLAERLSCCIRKLVLEHTSSLILPNSWETHRDLILSCLNMKETADKTIFDSLAERNSRIQLPSSRSDSTRQSAHQRVIQLFDSIQSSQDIASTSVACLNALEDRQTLVIKLLEWSATSFRSGLHRVYTAARLLRKWKISGVDIDTYIISFLSTVQDLAQLDMDNVYHIISELVRSQTFSVSRYLQWLMAKGVARKSSGTSGEVLAADARLLTQLPMSRSPEHVRNLRLTLLARAGVSVDEESSTIKCLKSSISQRLPNIFEVEASNSKHINFSKHDLTWAVKSEVSMWIRQGVVKHLKDTTRISALTPGEFYCVREILERFGDCSILADVLKQAIECDDNIILASVSDTVNYHFDALSMIGATSDLFRGLVGSYARLKRSGNLSLDFVFSLIELGLRLPDESGTVYLLRQDLARIESKSALAAPSPLSDHIPTTFNEVDASFQERLEQLLSCGNGLDESTMGAIISSLTKILTDGGGAAKVSAKDACRYLAYLRPFNPKYLDGMLVRYVYGLLKSSSRPTMSQVLSPLIGVGCVTIHSFVLLVNKLSASAQTTGAIANPDSLRLDILELLLPQEESSADMVTYRFRLAQQEFLVKYPEETLNIISDAIPLFDADFHDANLGSRRPDLPACTVVLLRTLLAQNSSLVLKYCMQKLDGHSSFTTVLGKAVDILLGLDPEDEMEPSSQAERVILMNNDFSLPYCQLKLKLLFNAKAGNEVKNHIVDVMFKAAVTDSRSKRSHWVGLVSLMDQEAARQIRERAEGCFFSVAMFDESMDDTSLPSGASSLSSIESAKLYLNIIEKLAYSIPQAGVQSIPPLLVERLDLLLQKLIIMQINSNSVAASSSGSTIVSKINFERALAFWFSALLRLIVLHRAAFNVPPASGSKVDSLREQTRLLVSILCISLARLPENILRLFPAADYFPHTIQSHNFRPCPGILLQTHALDVAASLIDSFPDEARHQCVRFLRERCPPFLKFQNDRRFLYLLGPMTDTTIPSSQLSASISSPAAGGSTPTPIPSGTLSGGHSSQATQQMAALTGPFSGLSENTKLVADRLRIQNGGRINGPYPVRPWELLEDAAPILGVNDTAVSLKLFDARRVRA
Length1582
PositionKinase
OrganismEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Nidulantes.
Aromaticity0.07
Grand average of hydropathy-0.158
Instability index49.51
Isoelectric point8.69
Molecular weight174503.59
Publications
PubMed=16372000
PubMed=19146970

Function

Annotated function Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex (By similarity). 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32593
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     417.94|     140|     215|     643|     798|       1
---------------------------------------------------------------------------
  643-  798 (207.40/194.24)	QLDMDNVYHIISELVRSQTFSVSRYlqwLMAKGVARKSSGTSgevLAADARLLTQLP.....MSRSPEHvrnlRLTLLARAGVSVDEesSTIKCLKSSISQRLPN...IFEVEASNS.KHINFSKhdlTWAVKSEVSMWIR..QGVVKHLKDTTRISALTP..GeFYCV
  866- 1018 (210.54/150.58)	NLSLDFVFSLIELGLRLPDESGTVY...LLRQDLARIESKSA...LAAPSPLSDHIPttfneVDASFQE....RLEQLLSCGNGLDE..STMGAIISSLTKILTDgggAAKVSAKDAcRYLAYLR...PFNPKYLDGMLVRyvYGLLKSSSRPTMSQVLSPliG.VGCV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     158.19|      45|      50|    1065|    1110|       2
---------------------------------------------------------------------------
 1065- 1099 (48.81/27.94)	................VTYRFRLAQQEFLV.KYPEETLNIISDAIPLFDADF
 1101- 1152 (62.82/40.34)	DANLGSRRPDlpactvVLLRTLLAQNSSLVlKYCMQKLDGHSSFTTVLGKAV
 1153- 1195 (46.56/23.35)	DILLGLDPEDemepssQAERVILMNNDFSL.PYCQLKLKLLFNA........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     126.61|      40|      69|    1274|    1314|       3
---------------------------------------------------------------------------
 1274- 1314 (60.93/40.22)	SAKLYLNIIEKLAYSIPQAGVQSIPPlLVERLDLLLQKLII
 1346- 1385 (65.68/39.38)	SALLRLIVLHRAAFNVPPASGSKVDS.LREQTRLLVSILCI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     195.40|      50|     214|      71|     136|       5
---------------------------------------------------------------------------
   80-  134 (86.87/60.13)	DITAESSANPASPTPATTGDSRVTPgiansKPSALSWRGRPVWSFQAM..ISEVMSG
  151-  170 (27.19/ 6.57)	.........PASPPPF...............PQP.SWKGAPPEQF............
 1473- 1524 (81.34/39.36)	DTTIPSSQLSASISSPAAGGSTPTP.....IPSGTLSGGHSSQATQQMaaLTGPFSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.45|      14|      17|       2|      15|       7
---------------------------------------------------------------------------
    2-   15 (28.66/16.70)	IPNSSAGG...QSWGHP
   19-   35 (20.79/10.03)	VDNDTARGdtsQAFNRP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.80|      10|      16|     543|     552|      10
---------------------------------------------------------------------------
  543-  552 (18.33/ 8.86)	IQLPSSRSDS
  562-  571 (17.47/ 8.10)	IQLFDSIQSS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32593 with Med12 domain of Kingdom Fungi
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