<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32592

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMSKTKNRNSLLSSHNRTSVSNSTKDELLAMKYVMDKPAIPLYPLNELSNSSESISEQNRYTSNSSTDELTYPDFKPWKDTTHLPKGKSEVEVEKLNNEAYLNKGYFEGPSVANEYYSARNLIQASLFSSSSNCDKVLKELSQHLVNSYRTRNEVINKIKYNSNKFKIPPRVTLTASKKEAWLRDLANPDEPLSNISNKLPHGIKNKMLVDILCSKNIPTSRALWLTKCVLYSELLVLKKKYQSRLPNNPHPVENTTSETFETQWLQEWTHQLVDYFYKFSKDMCNITIQEKKQVYLTKLNYLLNYVQALYIECLLDKSFFLTSILKFLKEGLPLDQSHVSELLAFSRSEGEESSLDKWLVDIDLNYGQRLISITLVKMFWKDILELDYLSKELSELLLLNYYFIERIPTYNTKSSNYSHKQNHTAALSSTLKLKLLSSISDTVNYLFKHNTNVFIIPNYWILVNETLYKILLSDVANSYDSEEQTEIRKQLKLIKYRNESLMLSMKDVQSSNFVDVNTARNLAKDRRRSNSLQQSLSQDTKNNYNSITGKKIPNTVENDNYFINRNSDDTLNIIDQLDRLKLNDTLAEMLIPSSISSSPDNFNDWRVNLKVVIYWAITIYREQMSSSEGILIICNFLKRKVLQNISVKNVNSIKAEFENEILEIIYNLAHCTDVDIIDYNLYVLINELYQLKVITISSYLRKLIASGLFYVSPSADGAQSHNENNSSVETHLAILQNLPVLNNKQCDSILRKWTPNGFNFEEKFEKGKLILKEELVDRLMSNSFDGYCDEKLTYIKNLKVGLKFLLVNWLTNYLKTSITKSPKLIHINPNIITSLYNFYALCDNLTVFFKVLIKFILRNEGKVIICYMDSLYLISKLIIRHFKLVKFIAGKSYESTTTGYELFKLIILNYKDLSTRDNDYYNFSDVWYFIDNAVEKNEPTYGKSSDGNNDNALKHKNFNQLLFAKETVDSPMRIHANSNTPQKNNDSYTATVFRNDLDLLLEAPIKLLNNTDITDFISTLELNVSNEAFNEISNTEESVIIIMEYYFKNIGEFTELHENLCMRLLINSKRSLDMTTRGIFFDIMKHFIINLVRTKPGIEKLITLFKKLMCFEVYQPHELFSTLRSILPRELSHEQMDALKYELLFGNPESDNKNLFNDQALVLRCIRYLYVKRHSNDVFITLLDSFSNEKETFFNSYALKAYNSKVLSFFRQFSISNTKFFMDGLSKVASNSDIISFLNLLIYISEEPIGSSSDLPRLASIIDEFNLPVCQVLIKIIIMNELRDSNKDKSIEKLRYILDMLLNNLKFHFVSYNSYFGELFNYLSWEHKLNILSIFEHNFLCNTEFIVSDDKFTENSVCLMSSDGRTNLLSILKDYFKKFSVSSLNTVTTSKEVFHNLSKFLLKVLQLANADIIGDSRRDAYNTISIFLRILIIHKLSLTSMIIEQDGQDLHFIKNLIALLESKFLCFNNEKLRILLYDLLLLMKSSITSSMILNPDSNLADDMTTDTSHQQHSPSNDYLSRSNPDGTEVGNSNSKYFGVSNISTIPNLSSVFNISEPNISYPLKKYTDDSKILCALMLEESELQKGGDIYALNDSKLILLPSRREALSSAFDILNETQQTVSKKRFKIESYELLEDTGIELNNGCINLSLFDAFTTKENPP
Length1661
PositionKinase
OrganismDebaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Debaryomycetaceae> Debaryomyces.
Aromaticity0.10
Grand average of hydropathy-0.275
Instability index37.92
Isoelectric point6.37
Molecular weight191931.19
Publications
PubMed=15229592

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex (By similarity). 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32592
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     521.51|     143|     160|     881|    1027|       1
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  418-  516 (74.92/35.97)	..SHKQNHTAALSSTlKLKLLssISDTVNYL..fkHNTNV..FIIPNYWILVNE.................tLYKiLLSDVA.NSYDSEEQT.EI.....RkQLKLIKYR...NeslmLSMKDVQSSNFVDV....................................................................
  881-  978 (145.10/77.14)	........................................................................HFK.LVKFIAGKSYESTTTGYEL.....F.KLIILNYK...D....LSTRDNDYYNFSDVW.YFIDNAVEKNEPTYGK.....SSDGNNDNA.LKHKNFNQL......LFAKETVDSPMR...IHANS
  981- 1147 (150.11/88.46)	PQKNNDSYTATVFRN.DLDLL..LEAPIKLL....NNTDItdFISTLELNVSNEafneisnteesviiimeyYFK.NI....G...EFT....ELhenlcM.RLLI.NSKrslD....MTTR..GI..FFDIMkHFIINLV.RTKPGIEKlitlfKKLMCFEVY.QPHELFSTLrsilprELSHEQMDA.LKyelLFGN.
 1148- 1254 (124.02/62.73)	PESDNKN....LF.N.DQALV..LRC.IRYLyvkrHSNDV..FITLLD.SFSNE............ketffnSYA.L......KAYNSKVLSF.F.....R.QFSISNTK...F....FMDGLSKVASNSDII.SFLNLLIYISEEPIGS.....SSD..........................................
 1451- 1497 (27.37/ 7.27)	......................................................................................................................................HFIKNLIALLE..........SKFLCFNNEkLRILLYDLL......LLMKSSITSSMI...LNPDS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.01|      13|      31|     595|     607|       2
---------------------------------------------------------------------------
  595-  607 (25.87/15.83)	ISSSPD.....NFNDWRV
  624-  641 (17.14/ 7.66)	MSSSEGiliicNFLKRKV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.58|      22|     156|    1377|    1399|       3
---------------------------------------------------------------------------
 1377- 1399 (31.91/27.21)	KKFSVSSLNTVTTSKEVFhNLSK
 1535- 1556 (38.68/27.10)	KYFGVSNISTIPNLSSVF.NISE
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     342.42|      86|     526|     737|     832|       4
---------------------------------------------------------------------------
  233-  307 (114.99/56.54)	ELLVLKKKYQSRLPNNPHPVENTTSETFETQWLQeWTHQLVDYFYKFSKD.MCN..ITIQEKKQV.YLTKL..NY......LLNYVQ................
  737-  831 (136.38/90.85)	NLPVLNNKQCDSILRKWTPNGFNFEEKFEKGKLI.LKEELVDRLMSNSFDgYCDEKLTYIKNLKV.GLKFLLVNW......LTNYLKtsiTKSPKLihinpNI
 1266- 1331 (91.05/44.20)	NLPV.....CQVLI.................KII.IMNELRDSNKDKSI.....EKLRYILDMLLnNLKFHFVSYnsyfgeLFNYL....SWEHKL.....NI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     123.32|      34|     156|     679|     712|       5
---------------------------------------------------------------------------
  679-  712 (57.05/44.67)	YNLYVLINELYQLKVITISSYLR...KLI...ASGLFYVS
  836-  875 (47.67/35.71)	YNFYALCDNLTVFFKVLIKFILRnegKVIicyMDSLYLIS
 1423- 1440 (18.60/ 7.98)	................TISIFLR...ILI...IHKLSLTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.10|      24|     504|     137|     161|       8
---------------------------------------------------------------------------
  137-  161 (37.01/29.53)	LKELSQHLVNSYRT..RNEVInKIKYN
  642-  667 (35.09/22.27)	LQNISVKNVNSIKAefENEIL.EIIYN
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32592 with Med12 domain of Kingdom Fungi
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