Description | Mediator of RNA polymerase II transcription subunit 12 |
Sequence | MSKTKNRNSLLSSHNRTSVSNSTKDELLAMKYVMDKPAIPLYPLNELSNSSESISEQNRYTSNSSTDELTYPDFKPWKDTTHLPKGKSEVEVEKLNNEAYLNKGYFEGPSVANEYYSARNLIQASLFSSSSNCDKVLKELSQHLVNSYRTRNEVINKIKYNSNKFKIPPRVTLTASKKEAWLRDLANPDEPLSNISNKLPHGIKNKMLVDILCSKNIPTSRALWLTKCVLYSELLVLKKKYQSRLPNNPHPVENTTSETFETQWLQEWTHQLVDYFYKFSKDMCNITIQEKKQVYLTKLNYLLNYVQALYIECLLDKSFFLTSILKFLKEGLPLDQSHVSELLAFSRSEGEESSLDKWLVDIDLNYGQRLISITLVKMFWKDILELDYLSKELSELLLLNYYFIERIPTYNTKSSNYSHKQNHTAALSSTLKLKLLSSISDTVNYLFKHNTNVFIIPNYWILVNETLYKILLSDVANSYDSEEQTEIRKQLKLIKYRNESLMLSMKDVQSSNFVDVNTARNLAKDRRRSNSLQQSLSQDTKNNYNSITGKKIPNTVENDNYFINRNSDDTLNIIDQLDRLKLNDTLAEMLIPSSISSSPDNFNDWRVNLKVVIYWAITIYREQMSSSEGILIICNFLKRKVLQNISVKNVNSIKAEFENEILEIIYNLAHCTDVDIIDYNLYVLINELYQLKVITISSYLRKLIASGLFYVSPSADGAQSHNENNSSVETHLAILQNLPVLNNKQCDSILRKWTPNGFNFEEKFEKGKLILKEELVDRLMSNSFDGYCDEKLTYIKNLKVGLKFLLVNWLTNYLKTSITKSPKLIHINPNIITSLYNFYALCDNLTVFFKVLIKFILRNEGKVIICYMDSLYLISKLIIRHFKLVKFIAGKSYESTTTGYELFKLIILNYKDLSTRDNDYYNFSDVWYFIDNAVEKNEPTYGKSSDGNNDNALKHKNFNQLLFAKETVDSPMRIHANSNTPQKNNDSYTATVFRNDLDLLLEAPIKLLNNTDITDFISTLELNVSNEAFNEISNTEESVIIIMEYYFKNIGEFTELHENLCMRLLINSKRSLDMTTRGIFFDIMKHFIINLVRTKPGIEKLITLFKKLMCFEVYQPHELFSTLRSILPRELSHEQMDALKYELLFGNPESDNKNLFNDQALVLRCIRYLYVKRHSNDVFITLLDSFSNEKETFFNSYALKAYNSKVLSFFRQFSISNTKFFMDGLSKVASNSDIISFLNLLIYISEEPIGSSSDLPRLASIIDEFNLPVCQVLIKIIIMNELRDSNKDKSIEKLRYILDMLLNNLKFHFVSYNSYFGELFNYLSWEHKLNILSIFEHNFLCNTEFIVSDDKFTENSVCLMSSDGRTNLLSILKDYFKKFSVSSLNTVTTSKEVFHNLSKFLLKVLQLANADIIGDSRRDAYNTISIFLRILIIHKLSLTSMIIEQDGQDLHFIKNLIALLESKFLCFNNEKLRILLYDLLLLMKSSITSSMILNPDSNLADDMTTDTSHQQHSPSNDYLSRSNPDGTEVGNSNSKYFGVSNISTIPNLSSVFNISEPNISYPLKKYTDDSKILCALMLEESELQKGGDIYALNDSKLILLPSRREALSSAFDILNETQQTVSKKRFKIESYELLEDTGIELNNGCINLSLFDAFTTKENPP |
Length | 1661 |
Position | Kinase |
Organism | Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Debaryomycetaceae> Debaryomyces. |
Aromaticity | 0.10 |
Grand average of hydropathy | -0.275 |
Instability index | 37.92 |
Isoelectric point | 6.37 |
Molecular weight | 191931.19 |
Publications | PubMed=15229592 |
Annotated function |
Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex (By similarity).
ECO:0000250 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP32592 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 5| 521.51| 143| 160| 881| 1027| 1 --------------------------------------------------------------------------- 418- 516 (74.92/35.97) ..SHKQNHTAALSSTlKLKLLssISDTVNYL..fkHNTNV..FIIPNYWILVNE.................tLYKiLLSDVA.NSYDSEEQT.EI.....RkQLKLIKYR...NeslmLSMKDVQSSNFVDV.................................................................... 881- 978 (145.10/77.14) ........................................................................HFK.LVKFIAGKSYESTTTGYEL.....F.KLIILNYK...D....LSTRDNDYYNFSDVW.YFIDNAVEKNEPTYGK.....SSDGNNDNA.LKHKNFNQL......LFAKETVDSPMR...IHANS 981- 1147 (150.11/88.46) PQKNNDSYTATVFRN.DLDLL..LEAPIKLL....NNTDItdFISTLELNVSNEafneisnteesviiimeyYFK.NI....G...EFT....ELhenlcM.RLLI.NSKrslD....MTTR..GI..FFDIMkHFIINLV.RTKPGIEKlitlfKKLMCFEVY.QPHELFSTLrsilprELSHEQMDA.LKyelLFGN. 1148- 1254 (124.02/62.73) PESDNKN....LF.N.DQALV..LRC.IRYLyvkrHSNDV..FITLLD.SFSNE............ketffnSYA.L......KAYNSKVLSF.F.....R.QFSISNTK...F....FMDGLSKVASNSDII.SFLNLLIYISEEPIGS.....SSD.......................................... 1451- 1497 (27.37/ 7.27) ......................................................................................................................................HFIKNLIALLE..........SKFLCFNNEkLRILLYDLL......LLMKSSITSSMI...LNPDS --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 43.01| 13| 31| 595| 607| 2 --------------------------------------------------------------------------- 595- 607 (25.87/15.83) ISSSPD.....NFNDWRV 624- 641 (17.14/ 7.66) MSSSEGiliicNFLKRKV --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 70.58| 22| 156| 1377| 1399| 3 --------------------------------------------------------------------------- 1377- 1399 (31.91/27.21) KKFSVSSLNTVTTSKEVFhNLSK 1535- 1556 (38.68/27.10) KYFGVSNISTIPNLSSVF.NISE --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 3| 342.42| 86| 526| 737| 832| 4 --------------------------------------------------------------------------- 233- 307 (114.99/56.54) ELLVLKKKYQSRLPNNPHPVENTTSETFETQWLQeWTHQLVDYFYKFSKD.MCN..ITIQEKKQV.YLTKL..NY......LLNYVQ................ 737- 831 (136.38/90.85) NLPVLNNKQCDSILRKWTPNGFNFEEKFEKGKLI.LKEELVDRLMSNSFDgYCDEKLTYIKNLKV.GLKFLLVNW......LTNYLKtsiTKSPKLihinpNI 1266- 1331 (91.05/44.20) NLPV.....CQVLI.................KII.IMNELRDSNKDKSI.....EKLRYILDMLLnNLKFHFVSYnsyfgeLFNYL....SWEHKL.....NI --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 3| 123.32| 34| 156| 679| 712| 5 --------------------------------------------------------------------------- 679- 712 (57.05/44.67) YNLYVLINELYQLKVITISSYLR...KLI...ASGLFYVS 836- 875 (47.67/35.71) YNFYALCDNLTVFFKVLIKFILRnegKVIicyMDSLYLIS 1423- 1440 (18.60/ 7.98) ................TISIFLR...ILI...IHKLSLTS --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 72.10| 24| 504| 137| 161| 8 --------------------------------------------------------------------------- 137- 161 (37.01/29.53) LKELSQHLVNSYRT..RNEVInKIKYN 642- 667 (35.09/22.27) LQNISVKNVNSIKAefENEIL.EIIYN --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) IPLYPL 2) LLAMKY | 39 27 | 44 32 |
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Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab