<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32591

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMASLNTPECPVMSSRPSMSCGNSSSSGLAIQGHSQRPSQTDPSAVEQAAQDSVIDLTNSDYETCDANRATKRQKLDLRIDVPNTQRAPKARFSQAVSSPFALQDTVPPIRTGRPFWDFGEEVSGFGFQGSLESEIPNDEPEQPDSLPPLPVRPWRYRPQGHSSREETPRVNQNAGAEVQTTPFCIEVPEAAPIFDSGKPLDFYPWKGDHPEDSLTDQTAKQGYYDRVQVSQNESNTARPSLYVQLKHRSGLKLLSSVFTAAIDKRQSHCRVTGFSTFKPPPRVTLTDIKRETWLRDLANPSVPLRRLSRTIPHGIRGRILLDQCVNKAIPIGRAVWLVKCVGANEIRAFKRKGTSAAITHSLEVKWVRDWSINVHQFIESVVTACGTPNWASTMSYVIRFAARLFQEQLLDQALCLDWFLQSLRTAPIGTLPIWLSMLGAYWTSLVRYRKRGRPLAESLLEKLKTILSLEDSGPKKQIADRLSWLIKTFAESHPACFVLPLTWRTYKSTLTTCFCLHLSEDNRKIGALSNRNERIVKAEICRQSGRQSPSQQVICLLDSADSLNDMEILSSGCLNLHFDHGSLIMKILEWVSTSFRRGSARVYVAVRLLRKWRRAGMDTDNCIVNFLQQKADTPGFSPANIYHLVCELVRSQSFAVGKYLQWLMARGAVRNDAPMHPTVQLLAHLPRRKLPSHVWNLRNTLLTKAGFLLSSENQQILNTKRYIHHRLPEVITKPIAGDNEGLFTPSDLSNLNWTIKSEIGHWIREHVSLHRKRYLRTAPNHHNACAIEISALTPAQFFEIRDIIECLGDLSLLADILKHTSSSDNIIVLISAVDTLNYCADSFKAIGALSDLFKSALAGYAHVNKADVSIIELISSLLEVGMKLPGEIPVVAMLRRDLSHFDKKFTGAVSSPVSDHTGESVNIASPAFSEGLHQLLNSGSGMDEPNMNKIFDMLSRKLKQSKEPNASSHEIARHLSQLRVLNSDVFDRLMVKWIISTLKSSPRPHLLTFLPPLIGVGCVTFEAFFALIDRLLKSDSHRQSIQDVSGLRYEMINLLRKEIFYELGSIDLVSYRFKTTREEYITHHAYDALGLVNEALANVNPESTSNPPLVPLLCELIIQNLNAFGPEGAGRIVEEFPNCVDIIHQALDVLLGLKAQVGVQKTQSVVGLIDDLSLSYCLVKLRLLLDANPDGDAARSSIVDLLFRTAESDIRNGERRWLEVLNVLPVSAAHLIRQRAEREILSLSLISSSLTTFSSEEDALIYLCIVEELSYSIPDEFSPSSMGADLGDKMFLLLQKTVELANAKKGTDLESGASSTALGVAELSIGVWFFVLLRLVALHRSLVPPNCDSRTEINHQTRLLVQICCISRSPLFARRSTQSFISSISTFTKCDSLLRMLPSSWANLQLQALDVCSTLVDTLSDEARYECARFLRDKCPAFLHPQNDARLLFLFGPIIESQSITTHGSSRASTSTPVTNLTQHVQSTPPPSQNTLTPGMVEEPNLFTNKLRFQQNGRITGPYPPKPWEMLGDAAPIIGINDTPVNLAYFGTRQSKRL
Length1554
PositionKinase
OrganismCoccidioides immitis (strain RS) (Valley fever fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Onygenales incertae sedis> Coccidioides.
Aromaticity0.07
Grand average of hydropathy-0.177
Instability index50.58
Isoelectric point8.37
Molecular weight173381.51
Publications
PubMed=19717792
PubMed=20516208

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex (By similarity). 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32591
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     212.72|     104|     205|    1137|    1255|       1
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  821-  878 (56.82/32.58)	SSSDNIIVLISAVDTLNYCADS......FKAIGALSDLFKSAlagyAHV..NKADVSI..IELISSLL.........................................................................................................................................................................................................................................................................................................................
 1137- 1186 (57.67/30.19)	....................................................................evgmklpgeipvvamlrrdlshfdkkftgavsspvsdhtgesvniaspafseglhqllnsgsgmdepnmnkifdmlsrklkqskepnassheiarhlsqlrvlnsdvfdrlmvkwiistlkssprphlltflppligvgcvtfeaffalidrllksdshrqsiqdvsglryeminllrkeifyelgsidlvsyrfkttreeyithhaydalglvnealanvnpestsnpplvpllceliiqnlnafgpegagriveefPNC...VDIIHQA.LDVLLGLKAQVGVQKTQSVVGLIDDLS.LSYCLVKLRLLLD
 1187- 1250 (49.44/61.07)	ANPDGDAARSSIVDLLFRTAESdirngeRRWLEVLNVLPVSA....AHLirQRAEREIlsLSLISSSL.........................................................................................................................................................................................................................................................................................................................
 1345- 1399 (48.79/23.43)	........................................................................................................................................................................................................................................ttfsseedaliylciveelsysipdefspssmgadlgdkmflllqktvelanakkgtdlesgasstalgvaelsigvwffvllrlvalhrslvpPNCdsrTEINHQTrLLVQICCISRSPLFARRSTQSFISSIStFTKCDSLLRMLPS
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     154.12|      43|      49|     134|     179|       2
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  134-  179 (73.15/47.70)	EIPNDEPeQPDSLPPLPVRPWRYRPQGHSSREETPRvnQNAGAEVQ
  186-  228 (80.97/43.65)	EVPEAAP.IFDSGKPLDFYPWKGDHPEDSLTDQTAK..QGYYDRVQ
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     273.52|      86|     222|     428|     555|       3
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  428-  519 (144.10/178.78)	IGTLPIWLSMLGAywtslVRYRKRGRP...................LAESLLEKLKTILSLEDS...GPKKQIADRLSWLI.KTFAESHPACF....VLPLTWrTYKSTLTTCFCLHLS
  656-  768 (129.42/79.83)	VGKYLQWLMARGA.....VRNDAPMHPtvqllahlprrklpshvwnLRNTLLTKAGFLLSSENQqilNTKRYIHHRLPEVItKPIAGDNEGLFtpsdLSNLNW.TIKSEIGHWIREHVS
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     103.62|      37|     205|     389|     427|       4
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  389-  407 (14.02/ 9.55)	.................................NWASTMSYviRFAARLFQE
  408-  444 (26.98/12.74)	QLLDQALCLDWFLQSLRTAPigtlpiwlsmlgaYWTS...............
  615-  651 (62.63/42.02)	AGMDTDNCIVNFLQQKADTP.............GFSPANIY..HLVCELVRS
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     373.79|     113|     221|      15|     129|       8
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   15-  129 (188.44/136.23)	RPSMSCGNSSSSGLAIQGH......SQRPSQTDPSAVEQAAQDSVIDLTNSDYETCDANRATKRQKL.DLRIDVPNTQRApKARFSQAVSSPFAlQDTVPPIRTGRPFWDF....GEEVSGFGFQG
  238-  353 (161.46/107.41)	RPSLYVQLKHRSGLKLLSSvftaaiDKRQSHCRVTGFSTFKPPPRVTLTDIKRETWLRDLANPSVPLrRLSRTIPHGIRG.RILLDQCVNKAI.......PI..GRAVWLVkcvgANEIRAFKRKG
  894-  930 (23.89/ 8.12)	.....................................................................LRRDLSHFDK....KFTGAVSSPVS.DHTGESVNIASP..AF....SE.........
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.05|      18|     375|    1027|    1056|       9
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 1027- 1056 (19.57/36.74)	LIDRLlkSDShrqsiqdvsgLRYEMINLLR
 1415- 1432 (33.48/19.71)	LVDTL..SDE..........ARYECARFLR
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32591 with Med12 domain of Kingdom Fungi
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