<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32590

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMIPSKYKLAPPDDLHPYSESERAKHKIYPDFDPWKHTKEEDEILLNFVSKGYYSTSKVNFESISARSSLQDSLPKLSSTLSEKFSEVVRIREREINTIKGNSKDGMAASKFTDLCGPDFKLPSRLTLTDHRKELWLQELSSPYTPLHKITSFIPHGLKRRQVLEQCYIKQIPLKRAVWLIKCCYSIEWKTGIAKYANSPQEKDKFNAHLLKEWTDNFVHILEKLIFEMTQHYNDSVKLEAWKTEVSYFLKLVGNCYTLELIDKNTFHFWILQFVSKVENFEYLPLPLHILELFWSGICNTNSTKVNESESNPLYMVTKLTDILLNQYYIILHSKSMINDDKYIINDIKKNNSIKESLLASIQKLICILFKQQSLEVFLFPPTSWEKYKPCLIQITSALYRKSDEVAEIKRKLELISYRNETLKYTPPISENKVKDDLILTTFTENSGSITVVELSQVDTGLTGALDDNATDFDWTSYSDQEISTKIQIIQIILWAIHPSRHSHYEAGQLAAKLLLLKINTMDGFPEYEIEDEIWSLVFKLAKLSDKSKALPAVLEALYSLLNTLIVYGLIKVSTYIRKLISSGILYLTESNDKYIHCRLLINLKMSPLMKSQYNMVLKNVMDQDPEYYNNYNFDQIVSIVEDLKVKLPNGDAIEYSNYPMSVKISLGEWYLTYLCNGKLVNETRESLTEKYVLFAHQLNTNHLYFKWIEFIVYHQLIEDIETLEYLMEVLLRYKKLFSQYINDHVLFIKTFIFIIRRILKERDSIAYSLTSFMDFWKFIMKSYSLEIRADTDLRSEMSAVYEEEKAKKEITEGEKDSWMGLYQNIHPDSTSLDQNHTGFSELFLTNLKTFLSSKQDKQAKKKARYNLLLLMQAKNRDYSKFISIYLKRKDFKTSDLVNLLSSKLLTLDQIKNTYGLKYVLELFDIESESNCVFYEYQKRCYIELNYKSVLSEYNVVSHHEMNRFIFKIVNHSTSAKLKETASALLTKNLEANKDKAIQLFYQLVYYQNNLEFLSSEELQEFAVNNSPQKLYSYLDFTNLWLFQSFTKFYIHETFQNTNEDKVKVGDVIFSIIETTKYNVLCAKIFEDIRDHRVTDLVIELFEQDFFKKIISGEEFKAEFLQMLIEIINHLSMHKGKTNDRSGEQSHTSYELCVQVMAHFQQLSDSELSAKEIELDVFMKIFTVHQNSVFQEILRDTESSSAMIESLFALFERVNFSLRLKLMFYEVLSSLKSYCTYEAGISDEQSRTKLMHKLMCLPPFQVSSFFPEEDDTDCTRDPALSLGLDLGTASANSTSSTTPSEGTHKKRCAIWDKRLHKYTGELQRKPYYCIKNYQDTEDINNCSLNLSLFDARYERNNPR
Length1358
PositionKinase
OrganismCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Nakaseomyces> Nakaseomyces/Candida clade.
Aromaticity0.12
Grand average of hydropathy-0.334
Instability index38.40
Isoelectric point6.17
Molecular weight158951.35
Publications
PubMed=15229592

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex (By similarity). 
GO - Cellular Component
mediator complex	GO:0016592	IEA:EnsemblFungi

GO - Biological Function
transcription coactivator activity	GO:0003713	IEA:EnsemblFungi

GO - Biological Process
negative regulation of transcription by RNA polymerase II	GO:0000122	IEA:EnsemblFungi
positive regulation of transcription by galactose	GO:0000411	IEA:EnsemblFungi
positive regulation of transcription by RNA polymerase II	GO:0045944	IEA:EnsemblFungi









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32590
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     453.46|     169|     212|     731|     940|       1
---------------------------------------------------------------------------
  731-  862 (122.39/94.67)	............................................................................................................LRYKKLFSQY..INDHVLFIKTFIF....IIRR....ILKERDS..IAYSLTSFMDFwKFIMKSYSLEIRadtdlrsemsaVYEEEK....AKKEITE.GEKDSWMGLYQNIhpDSTS..LDQNHTGFselFLTnlKTFLSSKQDkqakkK
  863- 1061 (217.73/133.78)	ARYNLLllmqaknrdyskfISIYLKRKDFKTSDLV.NLLS....SKLLTLDQIKNTYgLKYVLELF...........DIESESNCVFYEYqkrC...........yieLNYKSVLSEYnvVSHHEM..NRFIF...kIVNHstsaKLKETASalLTKNLEANKD..KAIQLFYQL..............VYYQNNleflSSEELQEfAVNNSPQKLYSYL..DFTNlwLFQSFTKF...YIH..ETFQNTNED.....K
 1075- 1220 (113.34/47.75)	TKYNVL............cAKIFEDIRDHRVTDLViELFEqdffKKIISGEEFKAEF.LQMLIEIInhlsmhkgktnDRSGEQSHTSYEL...CvqvmahfqqlsdseLSAKEI........ELDVFMKIFTVhqnsVFQE....ILRDTES..SSAMIESLFAL..FERVNFSLRLK.................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.99|      16|      44|     380|     395|       2
---------------------------------------------------------------------------
  380-  395 (33.28/25.29)	PPTSWEKYKPCLIQIT
  426-  441 (28.71/20.57)	PPISENKVKDDLILTT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     107.01|      26|      44|     301|     326|       3
---------------------------------------------------------------------------
  276-  296 (28.95/14.36)	...KVENF.EYLPLPL..HILELFWSG
  301-  326 (42.26/24.34)	NSTKVNES.ESNPLYMVTKLTDILLNQ
  345-  371 (35.79/19.49)	NDIKKNNSiKESLLASIQKLICILFKQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      28.99|      10|     144|     557|     571|       4
---------------------------------------------------------------------------
  533-  542 (17.83/10.51)	IWSL.....VFKLAK
  557-  571 (11.16/17.96)	LYSLlntliVYGLIK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.81|      23|      26|     628|     650|       5
---------------------------------------------------------------------------
  628-  650 (40.94/27.75)	YNNYNFDQIVSIVEDLKVKLPNG
  655-  677 (44.87/31.19)	YSNYPMSVKISLGEWYLTYLCNG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.67|      15|      26|     477|     491|       7
---------------------------------------------------------------------------
  477-  491 (23.79/14.00)	YSDQEISTKIQIIQI
  504-  518 (20.88/11.38)	YEAGQLAAKLLLLKI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32590 with Med12 domain of Kingdom Fungi
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