<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32588

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMIPHSSAGVQSWGHPLRAVNNGSGHVDASQAVGPPDPQFEKLPTPVPQPQPRQPAVIDLTTSGGDAQELEPPPKRLRLDLPAAPSARDASPAPGSGGELRSTPGTGGSKPPSLSWRNRPVWSFQAMLSEVPGSNVMNEEDATAVAQGGKPASPPSLPVLPWKYIPESLGSNPTTSRASSPVKEVQTIPYRIETPSVAPVLKGEKVADFSPWIGNHPEDVLNEQTAKQGHYDRTQVSQNESNTARPSLYAQLKHRSGLQMLSSVFAAALEKRQNHSLVTAPSTFKPPPRVTLTDNKREAWLRDLANPSVPLRKLSRTIPHGIRGKALLDQCLNKGIPVNRAVWLAKCVGANEIRAFKRKGTSGTLALGLEAKWVRDWTASVQQFLEGVLGACGSAQWKMKMTYAVSLTARLFFERLLDHDQYLGWFLSSLEAAPVNIVPVWLLMLGIYWDNIMRYRKRGRRLAELLLVKLRQVTQPDKGGPLQPLVDRLSLYVRRLVLEHTSSVVLPGSWENHKELISSCLNLKDNVHKTIYQNLSERNSRLQLPKNHQDTAERSPQQRVIQLFDSIRSAHDISSASTACLKTIEDKAILISKLLEWTATPFRYGLCRVYTGVRLLRKWKMSGIDVDSYILSFLADVRVTSALNMENIYHIISELVRSQTFSVGRYLQWLMAKGVTNTPQPVPSDLCLLKQLPANRLPEHVRNLRNTLLYRAGIPVMEEDSAIAELKISIAQRLPNIFGAEMDSAMPTESSQPHPTWAVKSEIGQWIRHGIAGHCRDSPRYVYLLSRSTAPANNYRKLSGVSVAVDPGASALTPDEFYSVREILETFGDLSMLADILKQATRCDDDVVLASVADTVNCHFDCFCVIGATADLFRGLVESYARLKRLGNASLDLLFSLIELGLRIPSEFNTVALLRQDLTRLENKSALAAPSPLSDSIPLALSDVDPSFQEKLNQLLSSGGGMDESTMDTVFYSLMHILENSGSPAKLSANETARYLAYLRPFQPKHFDTMLIRWICGLLKSSTPSMSRILPPLIGVGCVTIHAFVFLVKKLLQSEKVAAVIPNLAGLRVDLLQLLVPLVSGKSKYADLVTYRFHVAQQEFFMKHPQETLDIICDAVALVNSETGSNPGQPDIAGCATELLDILLTQNPEVTVQYCLQGFIGKHSTSTTVLERALDNLLGFDSLAGPPTMSEAEKVVRMTDDFSLPFCQLKLQMLFNAESGRNVGNGIVDVMFKAAVEDTRSKGSNWVGFVGLMSQDIIRQVWKHHYHYKNLEAHGHPGTAKSLETAKLYLTIIEKLAYSVPEAGVQSVAPILVEKMDLLLHRLVIMQTNFNNVTMNRHGAATTQILQSRSNFERSLAFWFSAFLRMIVIHRSAFTMPSPAPRANGLQEQSRLLISILCISLARLPDSVIRLFPAADYFPHPIPSQGYRPCPGILLQTHALDVAASLIDTFPDEARQQCARFLKEKCPPFLQYQNDSRFIYLLGPMSDAAALNSLQAASLPSPAAGGSTPTPTPSSALPGAPSNPQPTAMTPAVTSASLSEGINCVASHLRLQYRGRAMGPYPVRPWELLEDAAPIVGVNDTAVNLKYFDARRVRA
Length1594
PositionKinase
OrganismAspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Circumdati.
Aromaticity0.07
Grand average of hydropathy-0.143
Instability index50.32
Isoelectric point8.87
Molecular weight175555.72
Publications
PubMed=16372010

Function

Annotated function Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex (By similarity). 
ECO:0000250
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP32588
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.01|      23|      96|     667|     703|       1
---------------------------------------------------------------------------
  671-  697 (35.35/28.55)	AKGvtNTPQPVPSDlcLLKQLPANRLP
 1503- 1525 (44.66/15.30)	AGG..STPTPTPSS..ALPGAPSNPQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.61|      25|     314|    1045|    1104|       3
---------------------------------------------------------------------------
  196-  220 (45.41/12.04)	VAPVLKGEKVADFSPWIGNHPEDVL
 1047- 1071 (39.20/62.79)	VKKLLQSEKVAAVIPNLAGLRVDLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.94|      13|     317|     119|     136|       4
---------------------------------------------------------------------------
  119-  134 (21.59/24.18)	PV..WSFqamLSEVPGSN
  157-  171 (22.35/ 7.59)	PVlpWKY...IPESLGSN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     146.45|      49|     315|     393|     498|       5
---------------------------------------------------------------------------
  395-  465 (72.67/109.24)	QWKMKmtyavsltarlfferlLDHDQYLGWFLssleaAPVNIVPVwLLMLGIY..WDNIMRYR..KRGRRLAELL
  617-  670 (73.78/23.91)	KWKMS...............gIDVDSYILSFL.....ADVRVTSA.LNMENIYhiISELVRSQtfSVGRYLQWLM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     214.61|      53|     702|      42|     110|       7
---------------------------------------------------------------------------
   42-   94 (95.11/39.79)	LPTPVPQPQPRQPAV...IDLTTSGGD...AQELEPPPK.RLRLDLPAAP..SARDASPAPG
  745-  793 (82.03/32.50)	MPTESSQPHPTW.AVkseIGQWIRHGI...AGHCRDSPR.YVYL........LSRSTAPANN
 1530- 1573 (37.47/ 9.90)	............PAV...TSASLSEGIncvASHLRLQYRgRAMGPYPVRPweLLEDAAP...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     262.13|      80|     455|     504|     583|       8
---------------------------------------------------------------------------
  504-  583 (136.70/88.77)	VLPGSWENHKELISSCLNLKDNVHKTIYQNLSE..RNSRLQLPKNHQDTAERSPQQRVIQ..LFDS..IRSAHDISSASTACLKTI
  943- 1028 (125.43/80.79)	VDPSFQEKLNQLLSSGGGMDESTMDTVFYSLMHilENSGSPAKLSANETARYLAYLRPFQpkHFDTmlIRWICGLLKSSTPSMSRI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.50|      19|     702|     716|     735|       9
---------------------------------------------------------------------------
  716-  735 (28.63/21.80)	MEEDS..AIAELKISIAqRLPN
 1385- 1405 (28.87/16.86)	LQEQSrlLISILCISLA.RLPD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.08|      17|      89|     140|     156|      17
---------------------------------------------------------------------------
  140-  156 (30.30/18.53)	DATAVAQGGKPASPPSL
  231-  247 (29.77/18.06)	DRTQVSQNESNTARPSL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32588 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MIPHSSAGVQSWGHPLRAVNNGSGHVDASQAVGPPDPQFEKLPTPVPQPQPRQPAVIDLTTSGGDAQELEPPPKRLRLDLPAAPSARDASPAPGSGGELRSTPGTGGSKPPSLSWRNR
2) MLSEVPGSNVMNEEDATAVAQGGKPASPPSLPVLPWKYIPESLGSNPTTSRASSPVKEVQTIP
3) PSPAAGGSTPTPTPSSALPGAPSNPQPTAMTPAV
4) WIGNHPEDVLNEQTAKQGHYDRTQVSQNESNTARPSLY
1
126
1499
211
118
188
1532
248










Molecular Recognition Features






MoRF SequenceStartStop




1) ELEPPPKRLRLDLP
2) LPWKYIP
68
159
81
165