<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32587

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMIPHSSAGVQSWGQPLYAVYTGTGRADLSQPLGQPDRQSEQPSMPVAQTQGRPPALIDLTANDGDVLEREPPAKRLKIDVHAGSVANDGSPASAGVGESKSTPGATTSKPPSLSWRARPVWSFQSLLSEIPGSAEINGESAAGVVQDLKPPPPPSFSGPPWKFAPTDIIASDSAGEQDGASAKEVQTTPYHIETPSVAPVIRGEKVADFSPWMGNHPEDVLNEQTAKQGYYDRTQVSQNESNTARPSLYAQLKHRSGLQILSSVFAAALEKRQGHNMVTAPSTFKPPPRVTLTDNKREAWLRDLANPNVPLRKLSRTIPHGIRGRVLLDQCLTKWVPVGRAVWLAKCVGANEIRAFKRKGTSGALTIGLEAKWVRDWTANVQQFLEGVITSCGVADWKMKVTYAVNLTSRLFFEQLLDHDQYLEWFLTSLEAAPFNTLPVWLLMLGIYWSNILRYRKRGRRLAELLLDKLQLAIKSDSAPSLRPLIDRLSLHIRKLTLEHTSSMVLPQSWEKYKDLLSSCLNLNDNVHRTVFQILAERNARVQKPPKCEGTTQQPPQQRVIQLFDSICSSHDITSVSAASLRAIDDKAALVLKLLEWAATPFRYGVSRVYTGARLLRKWKIAGVDVDTCIISFLGESQMSDQLNMDNVYHIVSELVRSQTFSVGKYLQWLMAKGVADFSRSSDHQPLSGDLALLVQLPVSRLPEHVHNLRNTLLHRAGVEPSKEASTIAILKASIAERLPRIFGSVATSAVSCDPLPSDLTWTVKSELGQWIRRGVTEFGRDPRRAFQGLHSTTSAEHFALTPGEFYTVRDILESFGDLSILADVLKQATVCNDGIVLASAADTVNYHFRSFCVIGATTDLFKRLVEAYARLKRLGSTSLDLIFSLIDLGLRLPGELNTVALLRQDLSRIESKSSMAAPSPLSDHIPSSFNENDPLFLLKLDQLLSSASGIDESTLDTIFNVLIKQLESSGGHAKFSVNEICRYLSYLRPFHPKRFDTMIVRWVCGLLRSSTGGILSQVLPPLIGVGCVTIQAFVFLVRRLLKSDNKISNQRDLRIDLLQLLVPPPAGQSRYFDLVTYRFHLSRKEFLFKHPEEAFDIIRDAIALIDSESQEGNYRQVDLGHSAMVLLQILLTKNPESAVRHCSEKLIGQHPSAVTVLTRALDSLLGLDSKAGGHLFTSNDTFIFIPIDTGPATPDISVAEKVIELTNDFSLPFCQLKLQLLFNAESKGNVRNEIVDVMFKAAVADSRSRRSNWVGLVSLMSHDAVRQVKCHDIRERAEKNFFATPLFEESPDGCSSFAADNSSSLEAAKLYLAIIEKLAYSIPDVGPQAVVPVLTEKLDLLLQRLISMQASCSGTTELSHGVDAEQMIRSRTQFERALAFWFSALLRMIVLHRTAFSVPSAAVRPNALPEQTRLLISIFCISLARLPDSVLRLFPAADYFPHSMRAADCRPCPGILLQTHALDVAASLIDMFPDEARHQCARYLREKCPPFARVQNDSRFLYLLGPLGDSPSSNITLPVSIPSPAASGSTPAPTPSGNSTGGFSHPQQPAFVSGVPPGLPDGLNCAASHLCLQYRGRVIGAYPVRPWELLEDAAPIAGTNDTAVSLGYFDARRVRV
Length1617
PositionKinase
OrganismNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Fumigati.
Aromaticity0.07
Grand average of hydropathy-0.114
Instability index45.76
Isoelectric point8.39
Molecular weight178098.77
Publications
PubMed=16372009

Function

Annotated function Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex (By similarity). 
ECO:0000250
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP32587
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.54|      16|      16|     250|     265|       2
---------------------------------------------------------------------------
  247-  262 (26.29/15.24)	SLY.AQLKHRSGLQILS
  263-  279 (23.26/12.68)	SVFaAALEKRQGHNMVT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.77|      14|      16|     316|     331|       3
---------------------------------------------------------------------------
  316-  331 (18.82/19.45)	RTIPHGiRGrVLLDQC
  334-  347 (28.95/17.57)	KWVPVG.RA.VWLAKC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.47|      17|      19|      50|      68|       5
---------------------------------------------------------------------------
   56-   73 (24.53/13.95)	LIDLTANDGDVLE....................rEPPA
   75-  112 (15.94/ 9.33)	RLKIDVHAGSVANdgspasagvgeskstpgattsKPPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      33.58|      10|      19|     466|     475|       7
---------------------------------------------------------------------------
  466-  475 (16.12/ 8.52)	LLDKLQLAIK
  485-  494 (17.45/ 9.81)	LIDRLSLHIR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.97|      14|      20|     928|     947|       8
---------------------------------------------------------------------------
  934-  947 (23.61/22.89)	DPLFLLKLDQLLSS
  957-  970 (23.35/ 7.37)	DTIFNVLIKQLESS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.50|      18|      19|     855|     872|      11
---------------------------------------------------------------------------
  855-  872 (30.18/18.33)	IGATT.DLFKRLVEAYARL
  875-  893 (25.32/14.23)	LGSTSlDLIFSLIDLGLRL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.30|      16|      16|    1469|    1484|      12
---------------------------------------------------------------------------
 1464- 1479 (28.21/16.71)	DVAASLIDMFPDEARH
 1480- 1495 (31.08/19.20)	QCARYLREKCPPFARV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.44|      32|      67|    1041|    1072|      14
---------------------------------------------------------------------------
 1041- 1072 (55.91/40.85)	LLKSDNKISNQR..DL...RIDLLQ.LLVPPPAGQSRY
 1105- 1142 (40.54/27.29)	LIDSESQEGNYRqvDLghsAMVLLQiLLTKNPESAVRH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.77|      12|      21|    1512|    1523|      15
---------------------------------------------------------------------------
 1512- 1523 (22.83/14.39)	PSSNITLPVSIP
 1536- 1547 (24.94/16.53)	PSGNSTGGFSHP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.32|      11|      21|     363|     373|      26
---------------------------------------------------------------------------
  363-  373 (19.72/12.36)	GALTIGLEAKW
  387-  397 (21.59/14.30)	GVITSCGVADW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.97|      10|      21|     124|     133|      28
---------------------------------------------------------------------------
  124-  133 (17.16/ 6.56)	QSLLSEIPGS
  146-  155 (20.81/ 9.60)	QDLKPPPPPS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32587 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GTGRADLSQPLGQPDRQSEQPSMPVAQTQGRPPALIDLTANDGDVLEREPPAKRLKIDVHAGSVANDGSPASAGVGESKSTPGATTSKPPSLSW
2) PGSAEINGESAAGVVQDLKPPPPPSFSGPPWKFAPTDIIASDSAGEQDGASAKEVQTTPYHIETPSV
3) PVSIPSPAASGSTPAPTPSGNSTGGFSHPQQPAF
4) PWMGNHPEDVLNEQTAKQGYYDRTQVSQNESNTARPSLY
22
131
1519
211
115
197
1552
249










Molecular Recognition Features






MoRF SequenceStartStop




1) WGQPLYAVYTGTGRA
12
26