<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32586

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMIPHSSAGVQPWGHPLRAVHSASGLTDIPHALGQPDLHPEQSSMPAPQPQTGPSAVIDLTANGGEAQEREHPAKRLRLDIHSGSNARDGSPASAGLGEPKSTPVSTSSKPPPLSWRGRPVWSFQALLSEVPGAGEPNVESTTAAAQDVKPLSPPSFPAPPWKHSPADPTASSAAGLRGVTPAKEVRTTPYHIEVPSVAPVLRGDKVADFLPWTGNHPEDVLNEQTAKQGYYDRTQVSQNESNTARPSLYAQLKHRSGLQMLSSVFAAALEKRQGHSMVTAPSTFKPPPRVTLTDNKREAWLRDLANPTVPLRRLSRTIPHGIRGRVLLDQCLTKWVPVGRAVWLAKCVGANEIRAFKRKGTSGALAIGLEAKWVRDWTTNVQQFLDGVITSCGVADWKLKMTYAVSLTARLFFEQLLDHDQYLGWFLSSLEAAPLNTLPVWLLMLGIYWNHLLRYRKRGRRLAELLLEKLSKANKLDSSNTLRPLADRLSLHIRKLTLEHTSSAVLPHSWDKYKDLLSSCLNMKDSVHRAVIQNLSERNARVQRPRKCQETANQPPQQRVIQLFDSIRSTHDVTAVSIASLSAIDDKAALVFKLLEWVSTPFRHGICRVYTGARLLRKWKVAGVDVDSCIISFLAEGHDGSHLNMDNIYHIISELVRSQTFSVGRYLQWLMAKGVADCSKDSHQHHKHLSDDLELLLQLPVSRLPDHVRNLRNTLLHRAGIEVSKEEAMIATLKASIAQRLPNIFSSVTDSAMSCDVAQSELTWAVKSEIGQWIRRGVTEGRRGSTGKFQIAIGQPVLSADEFYSIRDILEGFGDLSMLADVLNQATNCDDGLILASAADTVNYHFQSFSVIGASTGLFRRFVESYARLKRLGVTSLDLILSLIDLGLHLPGEFNTVALLRQDLGRIENKSSMAAPSPLSDHIPATFNETDSLFPEKLDQLLFSGGGMDESTMDAIFNALITSLGRAEDRVKLSANDICRYLAYLRPFHPKHFDIMLIRWICGLLKSSTRTMLSRVLPPLIGVGCVTIQAFIFLVRRLLQSEKVASMIPHPNDLKIDLLQLLVPPPAGQSRYFDMVTYRFHLSQKEFLSKHPEETFNIIRDAIALIDSQDQDNHSDQGQMNLNQNAMVLLQILLTKNPESAVQYCTEKLITQHSTSMMVLTKALDTLLGFDTGPDPPNVSVAEKVIELTNDFSLPFCQLKLQTLFNAEAGSNVKNEIVDVMFKAAIADSRSRRSNWVGLVRLMNQDAVRQIRERAEKSFFAIPLFEEANEGRSMNNGTSLETAKLYLTIIEKLAYSIPDSGVQGVGSVLVEKMDLLLHKLVSMQTSYNGSTEMRHGIDAEQVIQSRTEFERSLAFWFSALLRMIVLHRSAFSIPPAPKSSASQEQTRLLISIFCITLARLPDSVLRLFPTADYFPHSMRQGDHRPCPGILLQTHALDVAASLIDMFPDELRHQCARFLKDKCSPFAQSQNDSRFLYLLGPLGDGPTSNATLPVSIPSPAASGSTPAPTPSGSLTAGPSNPPQPASASLGVPTGLPEGLNCGASHLCLQYRGRAIGAYPVRPWELLEDAAPIAGTNDTAVSLGYFDARRVRA
Length1591
PositionKinase
OrganismAspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Fumigati.
Aromaticity0.07
Grand average of hydropathy-0.187
Instability index46.12
Isoelectric point8.58
Molecular weight175525.82
Publications
PubMed=18404212

Function

Annotated function Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex (By similarity). 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32586
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.64|      10|     394|     106|     115|       1
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  106-  115 (21.92/ 9.20)	TSSKPPPLSW
  501-  510 (20.72/ 8.33)	TSSAVLPHSW
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     125.35|      30|      99|      25|      54|       3
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   25-   54 (53.71/29.03)	LT..................DIPHALGQPDLHPEQSSMPAPQPQTGPS
   59-  103 (26.91/10.45)	LTanggeaqerehpakrlrlDIHSGSNARDGSPASAGL..GEPKSTP.
  127-  155 (44.72/22.80)	LS..................EVPGA.GEPNVESTTAAAQDVKPLSPPS
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     124.48|      37|      40|     356|     395|       4
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  356-  395 (59.81/47.88)	FKRKGTsgaLAIGLEAKWVRDWTTNVQQFLDGVITSCGVA
  397-  433 (64.67/43.37)	WKLKMT...YAVSLTARLFFEQLLDHDQYLGWFLSSLEAA
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     105.07|      32|     488|     904|     988|       5
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  525-  556 (56.20/14.08)	DSVHRAVIQNLSERNARVQRPRK..CQETANQPP
  954-  987 (48.88/43.67)	DAIFNALITSLGRAEDRVKLSANdiCRYLAYLRP
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     186.30|      60|     488|     719|     819|       6
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  235-  297 (92.15/44.44)	QVSQNESNTArpSLYAQLKHRSGlQMLSSVFAAALEKRQGHSMVT..APSTFKPPPRVTLTDNKR
  722-  783 (94.14/112.62)	EVSKEEAMIA..TLKASIAQRLP.NIFSSVTDSAMSCDVAQSELTwaVKSEIGQWIRRGVTEGRR
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     155.30|      52|     170|     858|     928|       7
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  872-  928 (75.84/90.72)	LGVTSLDLILSLIDLglhLPGEF.NTVALLRQD....LGRIENKSS.MAAPSPLSDHiPaTFN
 1431- 1488 (79.46/46.66)	LQTHALDVAASLIDM...FPDELrHQCARFLKDkcspFAQSQNDSRfLYLLGPLGDG.P.TSN
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     300.34|      97|     156|    1093|    1196|      11
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 1093- 1196 (150.82/110.07)	EETFNiirdAIALIDSQDQDNHSDQG.QMNLNQNAMVLLQILLTKNPESAVQYCTEKLITQHStsmMVLTKALDTLLGFDTGPDPPNVSVAEKVIELTNDF..SLPF
 1256- 1355 (149.51/93.32)	EKSFF....AIPLFEEANEGRSMNNGtSLETAKLYLTIIEKLAYSIPDSGVQGVGSVLVEKMD...LLLHKLVSMQTSYNGSTEMRHGIDAEQVIQSRTEFerSLAF
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32586 with Med12 domain of Kingdom Fungi
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