Description | Mediator of RNA polymerase II transcription subunit 12 |
Sequence | MSSSRYILIPPEDLHPLTSNTGNEQNIYPDFDPWAHTEIEDKILLSFVAKGHYTSAKVNFESISARSSLQESLPKVAGMLAEQFSKVVHLREQTINKVSGESEESIRGKAKFTDLAGPGFSLPNRVTLTDQRRTQWLQELSSPNVSLSKLAKSIPHGFKRKQILEQCYMRQLPLQRAIWLIKSSYSIEWKSLTSKLKPGQTNEGVVSQLYNLWTNSMVSIMERLLFEMPKYYNDTAQAKIWKPRVSYYINLLGNCYNMGLMDRGVFNHWLVEFVEKVENFEFLPLSLHLLNIFWSGICPPTHGIEAPDNSFLISKITVVLLHKHHMILQNKSMINDENYIINDLQRNARLKESLLLRLKAFILDIFHHQSLEAFIMPNQNWDLYKNCLYEIVTMDKTSNEQAMVIKRKLELITYRNDSLQFNLLKQYKMKSSSLYESDGVEIDNLCDMQSILNVPFLDPEMTKILDNATPGYDWTLFVQQRFTCIEKVAQMIMWATNPSRKARYDGAHLVAKLLLLKTTSQENLPDYNMEDMIWKLVFHFSKLSERELSNIVELPSLYELLNIFIGYGIIKVPTYIRKLISSGIMYISDSKDKFFHCELLINLKISPLMKNQYNMMLKNIMEYDATYYVRYNYEQLQIQLNTAKEQMLQEQFEHISCLPISVKIWVSEWYLSYVCSPVDNVLKPVDKGTVIKNFTIFGLYLKEIFHFYKWVEFIVYHQLLADINALSALIDVLLYYENLFPLLINDQILFMKTLIHIYSKGLKNKDNLSYNITEFNPFWKFFMKHFPYLVEIDSDLQLQLGEVYESEKIRIEKLTKSSVDVITLYCNINQVNEESFKFGTHNFPGIFQQNLKILLKTESADACERARKGLSLLMLANLGDYTKFMSIFLKRKDYTIEQLVKLISVKLLTLDQIQKIIGDDILREILSRNNYGEGLWYELHKRNFIKKNFKIVLSMYRNSTSLDDRKLFLDLLVFYGPNSRLQEQVTTIICNCLRESNEDYSLILSLLRYGTKNIDQGTQETINIAKLYENLNFTNLWIFQAFTNYYTEALFNGATSDGQTITNFVFELIDLTRYNVLCSHLFDRVANFDVLEKLLEVFEADFFKKCLSEDPDDVHFLAVMIETIMNLSRKMNQSSAVISMNNESFRLLQATMLKFTSMNKTALCNSEMKLSIYLKIFIVHQKFIFQKVCDSLRQDRYDAEADLVKSLRLLFENTGFKLKLRLLLYDILSSLKSFVIYECTKKSESKRETRKLQISEALQNLPPFHISSFLDDMSISAHGDFDFLGLTEQPTPAEPEEGSQFFLYNKRTREYECGLNIEPFQLLPNHQSREPGSSCHFFNDTALSLSLFDARFDKKNPT |
Length | 1358 |
Position | Kinase |
Organism | Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Eremothecium. |
Aromaticity | 0.12 |
Grand average of hydropathy | -0.187 |
Instability index | 41.49 |
Isoelectric point | 6.54 |
Molecular weight | 158480.32 |
Publications | PubMed=15001715 PubMed=23749448 |
Annotated function |
Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex (By similarity).
ECO:0000250 |
GO - Cellular Component | mediator complex GO:0016592 IEA:EnsemblFungi |
GO - Biological Function | transcription coactivator activity GO:0003713 IEA:EnsemblFungi |
GO - Biological Process | negative regulation of transcription by RNA polymerase II GO:0000122 IEA:EnsemblFungi positive regulation of transcription by galactose GO:0000411 IEA:EnsemblFungi positive regulation of transcription by RNA polymerase II GO:0045944 IEA:EnsemblFungi |
Binary Interactions |
Repeats | >MDP32585 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 3| 358.10| 131| 169| 203| 371| 1 --------------------------------------------------------------------------- 174- 326 (204.57/177.77) LQRAIWLiKSSYSIEWKSLTSKLKPGQTNEGVV..SQLYNLWTNSMVSIMerllfEMPK.................YYNDTAQakiwkprvsyyINLLGNcYNM...GLMDR.GVFNHWLVEfVEKVENFEFL.PlslHLLNIFWSGICPPTHGIEAPDNSFLISKITVVLLHKHHM 344- 459 (113.45/84.11) LQRNARL.KESLLLRLKAFILDIFHHQSLEAFImpNQNWDLYKNCLYEIV.....TMDKtsneqamvikrklelitYRNDSLQ...........FNLLKQ.YKMkssSLYESdGVEIDNLCD.MQSILNVPFLdP.......................................... 1083- 1131 (40.08/ 6.67) ............................................................................................................................DRVANFDVL.E...KLLEVFEADFFKKCLSEDPDDVHFLAVMIETIMNLSRKM --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 245.41| 87| 170| 535| 704| 2 --------------------------------------------------------------------------- 535- 639 (121.31/84.87) KLVFHFSKLsereLSNIVELPSL......YE.LLNIFIGYGIIKVPTYIrKLISSGImyisDSKDkffhcELLINL.KISPLMK...NQYNMMLknimEYDATYYVR....YNYEQLQIQ 711- 812 (124.10/130.26) VEFIVYHQL....LADINALSALidvllyYEnLFPLLINDQILFMKTLI.HIYSKGL....KNKD.....NLSYNItEFNPFWKffmKHFPYLV....EIDSDLQLQlgevYESEKIRIE --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 110.02| 34| 168| 819| 853| 3 --------------------------------------------------------------------------- 819- 853 (56.38/37.25) VDVITLYCnINQVNEES......FKFGTHNFPGIFQQNLKI 985- 1024 (53.64/30.87) VTTIICNC.LRESNEDYslilslLRYGTKNIDQGTQETINI --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) ARFDKKN 2) SSRYILIPPED | 1350 3 | 1356 13 |
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Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab