<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32585

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMSSSRYILIPPEDLHPLTSNTGNEQNIYPDFDPWAHTEIEDKILLSFVAKGHYTSAKVNFESISARSSLQESLPKVAGMLAEQFSKVVHLREQTINKVSGESEESIRGKAKFTDLAGPGFSLPNRVTLTDQRRTQWLQELSSPNVSLSKLAKSIPHGFKRKQILEQCYMRQLPLQRAIWLIKSSYSIEWKSLTSKLKPGQTNEGVVSQLYNLWTNSMVSIMERLLFEMPKYYNDTAQAKIWKPRVSYYINLLGNCYNMGLMDRGVFNHWLVEFVEKVENFEFLPLSLHLLNIFWSGICPPTHGIEAPDNSFLISKITVVLLHKHHMILQNKSMINDENYIINDLQRNARLKESLLLRLKAFILDIFHHQSLEAFIMPNQNWDLYKNCLYEIVTMDKTSNEQAMVIKRKLELITYRNDSLQFNLLKQYKMKSSSLYESDGVEIDNLCDMQSILNVPFLDPEMTKILDNATPGYDWTLFVQQRFTCIEKVAQMIMWATNPSRKARYDGAHLVAKLLLLKTTSQENLPDYNMEDMIWKLVFHFSKLSERELSNIVELPSLYELLNIFIGYGIIKVPTYIRKLISSGIMYISDSKDKFFHCELLINLKISPLMKNQYNMMLKNIMEYDATYYVRYNYEQLQIQLNTAKEQMLQEQFEHISCLPISVKIWVSEWYLSYVCSPVDNVLKPVDKGTVIKNFTIFGLYLKEIFHFYKWVEFIVYHQLLADINALSALIDVLLYYENLFPLLINDQILFMKTLIHIYSKGLKNKDNLSYNITEFNPFWKFFMKHFPYLVEIDSDLQLQLGEVYESEKIRIEKLTKSSVDVITLYCNINQVNEESFKFGTHNFPGIFQQNLKILLKTESADACERARKGLSLLMLANLGDYTKFMSIFLKRKDYTIEQLVKLISVKLLTLDQIQKIIGDDILREILSRNNYGEGLWYELHKRNFIKKNFKIVLSMYRNSTSLDDRKLFLDLLVFYGPNSRLQEQVTTIICNCLRESNEDYSLILSLLRYGTKNIDQGTQETINIAKLYENLNFTNLWIFQAFTNYYTEALFNGATSDGQTITNFVFELIDLTRYNVLCSHLFDRVANFDVLEKLLEVFEADFFKKCLSEDPDDVHFLAVMIETIMNLSRKMNQSSAVISMNNESFRLLQATMLKFTSMNKTALCNSEMKLSIYLKIFIVHQKFIFQKVCDSLRQDRYDAEADLVKSLRLLFENTGFKLKLRLLLYDILSSLKSFVIYECTKKSESKRETRKLQISEALQNLPPFHISSFLDDMSISAHGDFDFLGLTEQPTPAEPEEGSQFFLYNKRTREYECGLNIEPFQLLPNHQSREPGSSCHFFNDTALSLSLFDARFDKKNPT
Length1358
PositionKinase
OrganismAshbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Eremothecium.
Aromaticity0.12
Grand average of hydropathy-0.187
Instability index41.49
Isoelectric point6.54
Molecular weight158480.32
Publications
PubMed=15001715
PubMed=23749448

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex (By similarity). 
GO - Cellular Component
mediator complex	GO:0016592	IEA:EnsemblFungi

GO - Biological Function
transcription coactivator activity	GO:0003713	IEA:EnsemblFungi

GO - Biological Process
negative regulation of transcription by RNA polymerase II	GO:0000122	IEA:EnsemblFungi
positive regulation of transcription by galactose	GO:0000411	IEA:EnsemblFungi
positive regulation of transcription by RNA polymerase II	GO:0045944	IEA:EnsemblFungi









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32585
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     358.10|     131|     169|     203|     371|       1
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  174-  326 (204.57/177.77)	LQRAIWLiKSSYSIEWKSLTSKLKPGQTNEGVV..SQLYNLWTNSMVSIMerllfEMPK.................YYNDTAQakiwkprvsyyINLLGNcYNM...GLMDR.GVFNHWLVEfVEKVENFEFL.PlslHLLNIFWSGICPPTHGIEAPDNSFLISKITVVLLHKHHM
  344-  459 (113.45/84.11)	LQRNARL.KESLLLRLKAFILDIFHHQSLEAFImpNQNWDLYKNCLYEIV.....TMDKtsneqamvikrklelitYRNDSLQ...........FNLLKQ.YKMkssSLYESdGVEIDNLCD.MQSILNVPFLdP..........................................
 1083- 1131 (40.08/ 6.67)	............................................................................................................................DRVANFDVL.E...KLLEVFEADFFKKCLSEDPDDVHFLAVMIETIMNLSRKM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     245.41|      87|     170|     535|     704|       2
---------------------------------------------------------------------------
  535-  639 (121.31/84.87)	KLVFHFSKLsereLSNIVELPSL......YE.LLNIFIGYGIIKVPTYIrKLISSGImyisDSKDkffhcELLINL.KISPLMK...NQYNMMLknimEYDATYYVR....YNYEQLQIQ
  711-  812 (124.10/130.26)	VEFIVYHQL....LADINALSALidvllyYEnLFPLLINDQILFMKTLI.HIYSKGL....KNKD.....NLSYNItEFNPFWKffmKHFPYLV....EIDSDLQLQlgevYESEKIRIE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     110.02|      34|     168|     819|     853|       3
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  819-  853 (56.38/37.25)	VDVITLYCnINQVNEES......FKFGTHNFPGIFQQNLKI
  985- 1024 (53.64/30.87)	VTTIICNC.LRESNEDYslilslLRYGTKNIDQGTQETINI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32585 with Med12 domain of Kingdom Fungi
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