<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32584

Description Mediator complex subunit Med15
SequenceMNRNVEKGWQTQIRPNERQSIALQIAQTLRIISPSISEVQLMNMALSFERQAFDGANSKNEYLTTCSKKTAQLRDQIREHLQAAQLKQAQNYSNNGNMNTVPSVPPVTAGRMAANSRVLPRMQNQTMPMQPGGVQQQFAGNVKLTPQQRQLLYQQSQIQQQQQPPQPATDTNQGRAAQPRVPPALSQQQLNNLCAQISTLLARTGTPPIALQKLQSMPPATLISLYQNQVQKFRSLQQLQQQQQKQIQQQSQQQGNVPFNANNAGQTYPNMANQQQTQPQVPQQPRPANIPSNANIRQNLEMLNIPVPKQLFAQIPGLPSNIKLWRDVTELGKNQRLTPEQAKAIGILYQKHMQVLLQHRQLKMQSARVNAQPTQTPQAPNKFGNVPVDPNVAPSASQQAYAQQMRNANVTNQPIKPQSTNVPINAETAPNPAKANYQNYVPTKARANSQALKSNLSPVDVPNVGTSSAEVNPAFNASVSPPSYPLKPTDATGAPQAGNQPTEKPFANASAPGNVSAFIVQQLLESGGTMGQQKMTVRIRELTERVMHSMIRPIPLDLPHDQKVIVAELVKSAYPMFSRTNQLIYLFYCLTANEEATIQLIQMRHIFKLQLEGLQQGVFTCTPQMMAKIKEKTSRYFAYVRTHLIRLHHEVNVNGQSLPAALAQISTSMRSSSAQQQQQQQQQQQQQQQQQQQSLQQGQQRNQKQQQPQQSPLQYQPAAAMQTQIAGVNKPQPNLPPQVRNIPKPTNEAGLDEQQLSYEAISKAQQEAQLKEKAISEVMKHTLRPEDLKLPMSKRKKLDNVSPPAISPLIQKPSLETPIEGHAMNAEETPVSGSLVNDGLNNTSAKEAESYKAREEATANPLKYAIDAFVTLDHEDEFSAVKSGLTPTSVIKTPQSFFIPSSTPDYNAGKSSLSPANILTLEGKFTYDDDAELWADGVQEGISVNGETKTAEPGIETKVGDESMNTDRTYKVPEEEDTFVKLMDDENDPWNDFIQEKQLTAKQKETGEEVNEFSSMNPSKIWQVVI
Length1026
PositionTail
OrganismSchizosaccharomyces cryophilus (strain OY26 / ATCC MYA-4695 / CBS 11777 / NBRC 106824 / NRRL Y48691) (Fission yeast)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Taphrinomycotina> Schizosaccharomycetes> Schizosaccharomycetales> Schizosaccharomycetaceae> Schizosaccharomyces.
Aromaticity0.05
Grand average of hydropathy-0.728
Instability index59.20
Isoelectric point9.15
Molecular weight114077.28
Publications
PubMed=21511999

Function

Annotated function 
GO - Cellular Component
chromatin	GO:0000785	IEA:EnsemblFungi
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
mediator complex binding	GO:0036033	IEA:EnsemblFungi
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:EnsemblFungi









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32584
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     149.99|      31|      31|     240|     270|       1
---------------------------------------------------------------------------
  146-  181 (29.26/ 7.22)	PQ.................qrqLLYQQSQIQQQ..QQPPQPATDTNQGRaaqpRV
  218-  268 (48.78/17.96)	PPatlislyqnqvqkfrslqqlQQQQQKQIQQQSQQQGNVPFNANNAGQ....TY
  269-  295 (28.45/ 6.77)	PN.................manQQQTQPQVPQQPRP.ANIPSNAN..........
  681-  711 (43.50/15.06)	QQ....................QQQQQQQQQQQSLQQGQQRNQKQQQPQ....QS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     180.82|      32|      35|     370|     401|       2
---------------------------------------------------------------------------
  370-  399 (47.75/19.59)	............NAQPTQTPQAPNKFGNVP.....VDPNVAPSASQQ
  400-  435 (39.36/14.80)	AY.....aqqmrNANVTNQPIKPQS.TNVP.....INAETAPNPAKA
  436-  482 (30.42/ 9.70)	NYqnyvptkaraNSQALKSNLSPVDVPNVGtssaeVNPAFNASVSPP
  501-  522 (28.00/ 8.32)	...............PTEKP.....FANAS.....APGNVSAFIVQQ
  730-  755 (35.29/12.48)	..............KP..QPNLPPQVRNIP.....KPTNEAGLDEQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     160.21|      41|      87|     524|     564|       3
---------------------------------------------------------------------------
  524-  564 (68.31/52.70)	LESGGTMGQQKMTVRIRELT.........ERVMHSMI..RPI.PLDLPHDQKV
  565-  612 (27.99/16.55)	IVAELVKSAYPMFSRTNQLIylfycltanEEATIQLIqmRHIfKLQLE.....
  614-  653 (63.91/48.76)	LQQGVFTCTPQMMAKIKEKT.........SR.YFAYV..RTH.LIRLHHEVNV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     121.75|      25|      29|     869|     897|       4
---------------------------------------------------------------------------
  834-  851 (20.29/ 8.26)	......SL..VNDGLNNTSA.KEAESY
  873-  897 (41.96/34.51)	DHEDEFSA..VKSGLTPTSVIKTPQSF
  901-  925 (34.67/17.24)	SSTPDYNA..GKSSLSPANILTLEGKF
  928-  952 (24.83/ 8.73)	DDDAELWAdgVQEGISVNGETKTAE..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     136.77|      29|      29|     763|     791|       5
---------------------------------------------------------------------------
  306-  331 (33.73/14.84)	P..VPKQlFAQI..PGLPSN....IK..LWRDVTEL
  332-  363 (31.11/13.14)	G..KNQR.LTPEQAKAIGILyqkhMQVLLQHRQLK.
  763-  790 (37.53/17.30)	...KAQQ.EAQLKEKAISEV....MKHTLRPEDLKL
  791-  817 (34.40/15.27)	PmsKRKK.LDNVSPPAISPL....IQ...KP.SLET
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.72|      17|      29|      99|     115|       7
---------------------------------------------------------------------------
   99-  115 (30.06/17.12)	NTVPSVPPVTAGRMAAN
  125-  141 (32.67/19.40)	QTMPMQPGGVQQQFAGN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32584 with Med15 domain of Kingdom Fungi
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