<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32579

Description Mediator complex subunit Srb8
SequenceMSSKEHISNADESNAASIVMCELDYRSNPESLLHYLASREALPDKRLYDEKTDAQPFSSAEAISKGHVYTSCVDDERGSAVFSIKNHLRNPIACRNLHKYSKALLSSQTSIPLGLPYTHFDPPPRVRLSETRKNAWLQDLANDKICLSSLSKKIPHGVWGKDIIQLVLDFRVPLPRAVWFIRCAGINEIRSYFKKYPCNSPKDWVFLWTDVIGDFLIDFFSNNQSKDDIQTFSGNFVYVNRLFGRLLTENLIVPSLFIAKVISLISDLPLYTCPSVITFLDYFSLIIIRDTSITRNCVLGLLPVLSKFNESPSIDLNIKRKVLSKAAEFLYRLASSNNSGFYFPNEWEDLYPVLSIIWKPNKTHDSLLSIVNDLNIRAICMVDASTTPVRFMQTLSNFKPSLNAYSFAKKILHYSYTESITFFLRWSIHSKNRTPEHRFCIFLSVLHFYKADHKLATNIILNYLFQVSSISNEESFIIAQLLNYLSLEGYFMFSGYVARLAALGYLRESMLMADFMDVQRKIILHLPLFQFSRQVRSKLNYILVRGSFIVDYDQCNTYVEQFQKNPSSFAFKKGESFSIIVYTLLKSFSICDDSVYRIYMALFNMYHYCMLKEFFDCVVYALNKPHIRASALLLLVKAFPNIVMDKRITDRIEMLKPENVIETYLLHEIKHLYQLDFDVASGSAEDESLCKQIQDLGESELFFKGVFGDDFHSFKALVCLYEEFFKIDDNTLLFSLTNSLLILKKHLGLSKNFNDVKCDVADLLQYKHANYSEFIVKLLRLYGNNILTVGDLWIILNRLLKTYEEDMKGHIVDIFMGAIFVDERDSEKDHLFYCLLWDAKSSDVGLEFLKFLIQYCSKNELTLRCIWNILRSLNFHEIIQVVPEKWLLRTIMEKYLSFPFHGMINESLIKHIFELDEFVTQLFAAWLTTLTKEELSDISEDVMENILTAGLTEKGLQSWHVICLGLPSTKQIFQRILLYSVNKDLDLPSHFLPFLSTITEYIVHEGPDKLFLEQLKTRLRSLFFTLKEQVLSAEIENDSLTSRIRRFSNIILQFHKYLEADEYANFLRILSAKKYIYKNQSLFESIAFVIDKVKTQPVNEDETFRSFHSWTNIECRSLSSDLPEALKEFHPRKTVIEPSIW
Length1141
PositionKinase
OrganismSchizosaccharomyces cryophilus (strain OY26 / ATCC MYA-4695 / CBS 11777 / NBRC 106824 / NRRL Y48691) (Fission yeast)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Taphrinomycotina> Schizosaccharomycetes> Schizosaccharomycetales> Schizosaccharomycetaceae> Schizosaccharomyces.
Aromaticity0.13
Grand average of hydropathy-0.016
Instability index43.51
Isoelectric point6.49
Molecular weight132549.63
Publications
PubMed=21511999

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:EnsemblFungi

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
negative regulation of cell-cell adhesion	GO:0022408	IEA:EnsemblFungi
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32579
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.44|      16|      20|    1093|    1108|       1
---------------------------------------------------------------------------
 1093- 1108 (28.16/17.77)	VKTQPVNED..ETFRSFH
 1113- 1130 (22.28/12.53)	IECRSLSSDlpEALKEFH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.06|      20|      20|     914|     933|       2
---------------------------------------------------------------------------
  914-  933 (33.19/23.87)	ELDEFVTQLFAAWLTT.LTKE
  934-  954 (26.87/17.80)	ELSDISEDVMENILTAgLTEK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.18|      20|      23|     846|     868|       5
---------------------------------------------------------------------------
  846-  866 (32.35/27.12)	LEFLKF..LIQYCSKNELtLRCI
  870-  891 (30.82/13.01)	LRSLNFheIIQVVPEKWL.LRTI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.69|      21|      66|     448|     468|       6
---------------------------------------------------------------------------
  444-  464 (34.06/19.76)	SVLHFYKADHKLATNIILNYL
  465-  485 (32.62/18.64)	FQVSSISNEESFIIAQLLNYL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.94|      18|      23|     577|     596|       7
---------------------------------------------------------------------------
  577-  596 (28.18/21.35)	FSIIVYTLLKSFSICddSVY
  603-  620 (38.76/22.71)	FNMYHYCMLKEFFDC..VVY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     209.77|      67|     849|     105|     180|      10
---------------------------------------------------------------------------
  105-  180 (99.03/104.72)	LSSQTSIPLGLPYTHfDPPPRVRLSETRKNawlQDLANDKI.CLSSLSKKIPHgvWGKDiiQLVLD.FRVPLpRAVWF
  956- 1024 (110.74/80.15)	LQSWHVICLGLPSTK.QIFQRILLYSVNKD...LDLPSHFLpFLSTITEYIVH..EGPD..KLFLEqLKTRL.RSLFF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32579 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




NANANA









Molecular Recognition Features






MoRF SequenceStartStop




NANANA