<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32577

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMDEHSAQDENNKMDTTPLPVSLNPEVIESRNLAPEIELPQIFQKIVQERGNFRDLDETELEKQLEEEEDSSKAFSGKQDPYYGFTILPSQQEGNDVSQNSMNIHDYKKELVDYILIAQNECSLALDMTSLLLSKYKQSSSDTISPFLKSTVPPGSLGLERCHPPEAKESDSILAMCWKRKSLTSSKNLLFDAKERLSKVVDSEREYFQILSNVRDSSWPLVLSNKGGNYDVSVQYSALGGISLGLGLVRKDQEKQSYNFESGLVHQKASLRVDLVSSTGKIIASSKWNWSWGIQEEEDQLLVKIQSAQRVLLEMDVWNALLQEAQICENQGVVFTGDTIVLSCNPEFSLRIFLDTNTEESRQDPEADFLNVDQEEEYDYETKKLSQRCCDAVNAITHILFLQYCRNPNRKLQQAELAMVIDASAPQIIRPLIFYYAIHEEARQFQNWLQNEGIKFEYLPSYPWESAQDFLTFENFLLTNRLSLQWYLDLDSSLPAHIQHNPTLHGTEKTVWKYKDAYNFYKFSSVKNMCQYIEHARKQRGEVASNAIQE
Length549
PositionHead
OrganismSchizosaccharomyces cryophilus (strain OY26 / ATCC MYA-4695 / CBS 11777 / NBRC 106824 / NRRL Y48691) (Fission yeast)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Taphrinomycotina> Schizosaccharomycetes> Schizosaccharomycetales> Schizosaccharomycetaceae> Schizosaccharomyces.
Aromaticity0.09
Grand average of hydropathy-0.543
Instability index54.78
Isoelectric point4.84
Molecular weight63066.96
Publications
PubMed=21511999

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:EnsemblFungi

GO - Biological Function
transcription coactivator activity	GO:0003713	IEA:EnsemblFungi

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32577
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     201.65|      67|      78|     294|     370|       1
---------------------------------------------------------------------------
  294-  370 (96.71/105.39)	QEEEDQLLVKiQSAQRVlleMDVWNAL..LQEAQICENQGVVFTGDTIVL...SCNPEFsLR..IFLDTNTEESRQdpeadFLN
  373-  446 (104.94/80.51)	QEEEYDYETK.KLSQRC...CDAVNAIthILFLQYCRNPNRKLQQAELAMvidASAPQI.IRplIFYYAIHEEARQ.....FQN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.79|      23|     210|     255|     277|       3
---------------------------------------------------------------------------
  255-  277 (39.89/26.59)	QSY.NFESGLVHQKASLR..VDLVSS
  467-  492 (30.90/19.05)	QDFlTFENFLLTNRLSLQwyLDLDSS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32577 with Med17 domain of Kingdom Fungi
Unable to open file!