<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32574

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMQQDEVQFLNLSAIPCPETIFYAKYELQKSESEAILQDLYELEASLSEKSRIFYVLDGSLFLYSFDSIPLLPGLRPSTLTLNSSGSFGRSSFFHHESNPRTSSIQLNLIRALRRLTVYHLCKEYGFLSLKEFLLPIRTASKFILEGLSVHEFPLLGLHLGFLTDGFMEFSFRPVGLSLYCLSNIANLEEYVVERLILLPFGCNAKLISIQAPSSLSTMEILKSRYGFFNLPTEKWVGVQVDCFDYAFSWPLSLCFLEKTPFPTHLQNDFDKHFTINGYTLPFNASKDLLSEKKVHLDQNKEVISDSDNLDHTVSPNVAVTPVLPNTLAIPSSPELPIRVTHSPFPSSERVMEESDRENDLFMQDIEDARITEADFDYFDLPNPEVKPYSENMEVIEQKSESLNQVDLEAISEEKQLNNQQFPSPPDTYTQSEHSIQKKESTKSISEPTIPQDNFKLSIMDDLIVEKYYHDEVVPPLYNAVPFPSSSVDIAKKYSIGGKYWCPSALLHRSDSLGSLSGSVSSVEEEKHFYDGLREVVERQPVSEMKNNINPEVSFPSLEKEGSELYSSASVDCSGVDTGVNDSFGFESLLEKYGLKHLKMVEKEALLELIMSQPFYFYLLPFWKNQNSYINSYNDSCDFLYIQEATKEFLEGLFSGLSRAISLSSCTSWETEINGNNSKDVNKANTYITSVDQPGVILKSNNQKLTVDYNATKHWSSLNLQPYNETRNYTVLPFSQKKPESIPIVKSLFDDIRYAYENCQFGKLELGNLITFQEDGIIDYNSLFSSSFCDSGDQATEHKSTLNFTNLAKECASAYANDDLLFLFFVDDSVYSFFSVCQSFTLLNEVFSLETKKDGLFNNQLFIKIIPSSAGFTISQPLATETLSPTNIAMDIYSTSPLRNPSLKVKYSPFVMEKPVISLLNYKLSNTFSANAVFNDYSLHVTYTVIRDKFLICMWNDTYGELENCEWFLLSETNQKLDVFQKIWKTSSEIMKIGSFTWSLNIMKVGALSLEELNDWKQVAESQEFMDKSTLVIGNCLIHESSKPQLKPYLRMFFRSSNNPDDSLEISENIEIVGIVREAATLIPHFTTLDIKPCLAYGSLGFSESGNVVPIADIHLFYVKQTEPVLALRKILREYLFMSFTSRKNNFSSIRIPHNISTVLYQRQLLEYLSGDDH
Length1173
PositionKinase
OrganismSchizosaccharomyces cryophilus (strain OY26 / ATCC MYA-4695 / CBS 11777 / NBRC 106824 / NRRL Y48691) (Fission yeast)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Taphrinomycotina> Schizosaccharomycetes> Schizosaccharomycetales> Schizosaccharomycetaceae> Schizosaccharomyces.
Aromaticity0.12
Grand average of hydropathy-0.228
Instability index46.08
Isoelectric point4.86
Molecular weight133440.37
Publications
PubMed=21511999

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP32574
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     206.05|      68|      80|     747|     819|       1
---------------------------------------------------------------------------
  747-  819 (109.49/89.20)	LFDDIRYAYEN.CQ.FGKL.ELGNLITfQEDGIIDyNSLF......SSSFCDSGDQATEhksTLNFTNLAKE..CASAYANDDL
  824-  902 (96.56/61.64)	FVDDSVYSFFSvCQsFTLLnEVFSLET.KKDGLFN.NQLFikiipsSAGFTISQPLATE...TLSPTNIAMDiySTSPLRNPSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     110.15|      38|      81|      46|      92|       2
---------------------------------------------------------------------------
   46-   92 (46.64/55.84)	LSEKSRIF.......YVLDGsLFLYSFdsiPLLpGLRPSTLTlnsSGsFGRSSF
  127-  171 (63.51/38.86)	LSLKEFLLpirtaskFILEG.LSVHEF...PLL.GLHLGFLT...DG.FMEFSF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     313.15|      68|      79|     328|     395|       3
---------------------------------------------------------------------------
  212-  296 (82.30/43.57)	PSSLSTMEILKSRYGFFNLPTEKWVGVQVDcFDYaFSWPLSlcflEKTPFPTHLQND.fdkhftingytlPF...........NASKDL.LSEKKV.HL
  297-  344 (74.88/38.97)	DQNKEVISDSD..................N.LDH.TVSPNV....AVTPVLPNTLAI..........................PSSPELPIRVTHS.PF
  345-  437 (92.23/49.72)	PSSERVMEESDRENDLFMQDIEDARITEAD.FDY.FDLPNP....EVKPYSENMEVIeqkseslnqvdleAIseekqlnnqqfPSPPDTYTQSEHSiQK
  438-  482 (63.74/32.07)	KESTKSISEPTIPQDNFKLSIMDDLIVE....KY.YH..DE....VVPPLYNA...........................................vPF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     260.16|      83|     365|     550|     743|       5
---------------------------------------------------------------------------
  550-  639 (129.72/186.92)	PEVSFpsLEKEGSELYSSASV..DCS.GVD.TGVNDSFGFESLLEKYGlkHLKMVEKEALLEliMSQPFYFYlLPFWKNQNSY..INSYNDSCDFL
  914- 1002 (130.44/39.77)	PVISL..LNYKLSNTFSANAVfnDYSlHVTyTVIRDKFLICMWNDTYG..ELENCEWFLLSE..TNQKLDVF.QKIWKTSSEImkIGSFTWSLNIM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.01|      27|     366|     686|     743|       6
---------------------------------------------------------------------------
  713-  743 (41.55/65.22)	HWSSLNLQPyneTRNYTVLPFSQkKPESIPI
 1084- 1110 (49.46/16.03)	HFTTLDIKP...CLAYGSLGFSE.SGNVVPI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32574 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) KPYSENMEVIEQKSESLNQVDLEAISEEKQLNNQQFPSPPDTYTQSEHSIQKKESTKSISEPTIP
386
450










Molecular Recognition Features






MoRF SequenceStartStop




NANANA