<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32571
Description |
Mediator of RNA polymerase II transcription subunit 8 |
Sequence | MDIISSEKAVESLEGIRQRTTQIVHSLSHFLAILHQTEQLAPWPTIHKNFNILLSQIHSLSNTLAIHFQSLRTTNIFPSEEFPVREQEPLLTTLLRTRPLPNVEEWEATTLEEYENDTSLKSKNQKQPLRQDELWEEARDLLTQEREQYNWTGYVTRQEELQGEIINQKELEAERAFEEQSAQQTLTKILAFMKSGRR |
Length | 198 |
Position | Head |
Organism | Schizosaccharomyces cryophilus (strain OY26 / ATCC MYA-4695 / CBS 11777 / NBRC 106824 / NRRL Y48691) (Fission yeast) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Taphrinomycotina>
Schizosaccharomycetes> Schizosaccharomycetales> Schizosaccharomycetaceae>
Schizosaccharomyces.
|
Aromaticity | 0.07 |
Grand average of hydropathy | -0.716 |
Instability index | 60.16 |
Isoelectric point | 5.15 |
Molecular weight | 23253.79 |
Publications | PubMed=21511999
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364144
|
GO - Cellular Component | mediator complex GO:0016592 IEA:EnsemblFungi
|
GO - Biological Function | transcription coactivator activity GO:0003713 IEA:EnsemblFungi
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP32571
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 78.65| 25| 31| 86| 116| 1
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91- 115 (43.81/30.04) LTTLLRTRPLPNVEEWE.ATTL..EEYE
120- 147 (34.84/10.05) LKSKNQKQPLRQDELWEeARDLltQERE
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 49.65| 13| 31| 24| 36| 2
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24- 36 (24.92/16.11) VHSLSHFLAILHQ
57- 69 (24.73/15.94) IHSLSNTLAIHFQ
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|