<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32564

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMDVRTNGHTPSLPTVPATTNGYHEPEPSVEELERELPVVYDGQVPLAELVSRTVQAIYAELSELAETLPNMSDAARKRTLADWVVKTKKQVVKLYAIVKWSRDAGVVQKAMNVTAFLMDQKRQFEEAIHGLKYAKESLDPARLRNHDLLTSLDVLTTGSYRRLPSAIKKVVVPPTPLSDEEVSRTLADVENVIRFRLKMFELVPIEMSRYRIAEGRVYFTVPRLFEVSLCVRGAEKDAGWFFVNVEFLLNVGGDPTSIQEFPRKPIGWLKRNITDEADARLAFYLPLPADQPLSPEAPEAPPRPQLPEGVVDAPLVRVFNFLQMMSMSYMLEILCYQAGRLRALGWGDYLRIQMSRDRKTLTMSYWVRQPPKEPSLKRLNLPLLGGKLIISIARAPTSAINKANRPPKARVLAELQEKAKLRGGRPSDEVEPHELQVKWEPERNALGIPIPPGDCVLAKNELSIDSDNLDLEALLRKVATKHVGAILRVVQHRLQNDPAMRSTFGPPGEVTLAEDEGVQTLQAHLCADEVVVMTVDTRTGRLNLRDTGDLAAANRGRRFTVITDRLNDNPTILYEALSRLKLGTILDLAEQKANYLGLQSYRVRNFAPQEIQKLGPTARGMLYIELAKFPDHFLVLVVTDDDWRFALISVETIQDTPCHDLVMKDIGWLDVRRIHGEEIVVAPRPPTHAGDPAVGQPREREAVELPAEPPATDNLNYTPRYALETQVLREVYAYCCARVAFYKIEQQFKTRNIPYTTVACTNVAQTPELAHLQSGLSRSVPLLCVQSSDILSGAPAAEAAMPNIRVIPLNWWNDEKQAQVVTCVKLKYVQQPVGKRAGSNVIRPSKRIIYDTTEAIVSFLSEDVDKCVDEFLEEWARVSKIVVIAREVAQMATEKHWMDVRLLSFDLQTVEFAYAGDYTVSITCTDQLSATGGSYDLLFSRIGAGDTRLGDMDVDERCNPHEDLEPFLRNVLRHGRLAPSLQRLVRLLRDSLSVVVELEEIRQAVASAPENVDVFPKAAGWFRILYGDFRHALDFRIMTGARVVILDASHSLFSDASPTTSGSKPPSAQGLGHARKPSSTSIMPAIPPASSDSHLLLQAIPDFQRIVGEVIQNAASRGCTAHIVSIETGIVCDSAAVSFVARTLHERVLQRLKQG
Length1155
PositionTail
OrganismFomitopsis pinicola (strain FP-58527) (Brown rot fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Polyporales> Fomitopsis.
Aromaticity0.07
Grand average of hydropathy-0.194
Instability index46.67
Isoelectric point6.32
Molecular weight128873.45
Publications
PubMed=22745431

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP32564
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     194.90|      50|      98|     253|     315|       1
---------------------------------------------------------------------------
  253-  304 (89.65/51.33)	GDPTSIQ.EFPRKPIG...WLK.RNITDEADARLAfyLPLPA........DQ.PLS.PEAPEA....PPRP
  347-  406 (59.58/33.04)	GDYLRIQmSRDRKTLTmsyWVR.QPPKEPSLKRLN..LPLLG........GKlIISiARAPTSainkANRP
  664-  709 (45.67/19.01)	............KDIG...WLDvRRIHGE.EIVVA...PRPPthagdpavGQ.PRE.REAVEL....PAEP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.20|      15|      15|      34|      48|       2
---------------------------------------------------------------------------
   34-   48 (25.31/15.03)	RELPVVYDGQVPLAE
   52-   66 (22.88/12.86)	RTVQAIYAELSELAE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     227.11|      76|      99|     407|     504|       3
---------------------------------------------------------------------------
  407-  487 (117.10/80.81)	PKARVLAELQEKAKLRGGRPSDEVEPheLQVKWEPERNALGipiPPGDCVLAK..NELSIDSDNL.DLEALLRKVATK.HVGAIL
  507-  586 (110.01/61.76)	PGEVTLAEDEGVQTLQAHLCADEVVV..MTVDTRTGRLNLR...DTGDLAAANrgRRFTVITDRLnDNPTILYEALSRlKLGTIL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.65|      29|     104|      71|     102|       4
---------------------------------------------------------------------------
   71-  102 (46.25/36.99)	MSDAARKRTLADW..VVKTKkqvVKLYAIV..KWSR
  177-  209 (39.40/23.75)	LSDEEVSRTLADVenVIRFR...LKMFELVpiEMSR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.24|      11|      15|     587|     597|       5
---------------------------------------------------------------------------
  587-  597 (18.62/12.01)	DLAEQKANYLG
  605-  615 (19.62/13.05)	NFAPQEIQKLG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.82|      17|     772|     221|     241|       6
---------------------------------------------------------------------------
  211-  227 (29.68/30.32)	RIAEGRVYFT...VPRLFEV
  232-  251 (25.14/11.45)	RGAEKDAGWFfvnVEFLLNV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32564 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MDVRTNGHTPSLPTVPATTNGYHEPEPSVE
1
30










Molecular Recognition Features






MoRF SequenceStartStop




NANANA