<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32559

Description Mediator of RNA polymerase II transcription subunit 6
SequenceMDLNDLHPPDDYSHRFFIWHEWIQANGPLTNGNVFDYFATSMFYDKQSNNQVLRMQTMHTGVPLENETEELRRFTGIEFAVVHSQPPGLFIIHKRERLSPDEVRPLVAYFIMNNRIYQSPDVYSLVSNRLLTSLQALQTSLDILRSHRPSYTPRTGFVWPIVESTDPLKRAEETNDERPATQGAESQSQDRELSPTQSKRAKAASSNPRQQNVMLLVNAIRTTALHATESFTLPTAVPTESTPAVPEGQTPGAGPGPTPGARSAAATPAPATRGATPVGNKRAGSPLDREPTKGQPGAGKKKKRRTATLNSVTS
Length314
PositionHead
OrganismFomitopsis pinicola (strain FP-58527) (Brown rot fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Polyporales> Fomitopsis.
Aromaticity0.07
Grand average of hydropathy-0.658
Instability index57.67
Isoelectric point9.29
Molecular weight34678.43
Publications
PubMed=22745431

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32559
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     139.66|      33|      90|     179|     211|       1
---------------------------------------------------------------------------
  179-  211 (53.14/19.69)	PATQGAESQSQDRELSPTQSKRAKAASSNPRQQ
  243-  268 (36.83/11.96)	PAV..PEGQTPGAGPGPTPGARSAAATP.....
  270-  302 (49.69/18.06)	PATRGATPVGNKRAGSPLDREPTKGQPGAGKKK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.27|      17|      18|      90|     107|       3
---------------------------------------------------------------------------
   90-  107 (27.51/18.62)	FIIHKRERLSPDeVRPLV
  110-  126 (32.76/18.07)	FIMNNRIYQSPD.VYSLV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32559 with Med6 domain of Kingdom Fungi
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