<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32555

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMSDASPHPHSQEPPWKKIKLSLERPYKDDDGIPIPDLLDIAVDGQHVYEPKEDATAKVGENLRRIFVERGVDYFERKKDAPGPVAEPDASMEEDAADAKDDETQDPRQPMTTEELYKMRVELLPHLHIALGEMTQARDLLSMLLSTAGPSSTPSVAQLLSQSTLSSSQSAPPSPPHNLTATVVTKPPPILSVRAFDAQLVVGGKDRALRRAADLFNAAAENMEAGRARSERYWYDALCIRRGNWGLVPAPLPPGSATGKGADKTSKDFLVSFGLEEAPAIFRRRAIGRMPTLDRDQSRIEFPLRQNTRLRVLLRKTCEDGTSCTATNVISVLEETTLEESLRAAQIEVVEQEIFSALIKEAGSLPTATAHVSERSIVIKAAQGTDLTIQLVDSQREHDAPSSTAMAATCDLIAATLQVLLLRVHSYMRNERIRRTGSIRTSTQPIVLQPPPVLLPIIDLLQYERFCHRVLAEFERIVGALRRAGMPTKIHFEAMAGSGEEFLKLVTETKPKPAGGEARIRIDNRHTLRFTFISPSMLIAHLPQGTLCIASIAQLSQLLADEVGMFLLRRICDIGTDRCSGVSNAWFVDALSSKSIGKWDGCVLYV
Length605
PositionHead
OrganismFomitopsis pinicola (strain FP-58527) (Brown rot fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Polyporales> Fomitopsis.
Aromaticity0.05
Grand average of hydropathy-0.246
Instability index51.30
Isoelectric point6.07
Molecular weight66626.46
Publications
PubMed=22745431

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32555
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.88|      23|      23|      36|      58|       1
---------------------------------------------------------------------------
   36-   58 (38.79/30.35)	DLLDIAVD.GQHVYEPKEDATAKV
   61-   84 (37.09/28.65)	NLRRIFVErGVDYFERKKDAPGPV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.09|      12|     261|     179|     190|       2
---------------------------------------------------------------------------
  179-  190 (22.39/11.61)	TATVVTKPPPIL
  442-  453 (23.70/12.68)	TQPIVLQPPPVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.95|      16|      16|     139|     154|       3
---------------------------------------------------------------------------
  139-  154 (27.17/16.12)	LLSMLLSTAGPSSTPS
  158-  173 (26.78/15.79)	LLSQSTLSSSQSAPPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.70|      12|     252|     312|     323|       4
---------------------------------------------------------------------------
  312-  323 (24.37/15.20)	LLRKTCEDGTS.C
  566-  578 (20.33/11.57)	LLRRICDIGTDrC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.82|      14|     416|     118|     135|       5
---------------------------------------------------------------------------
  106-  119 (25.43/21.89)	PRQPMTTEELYKMR
  124-  137 (24.39/10.10)	PHLHIALGEMTQAR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32555 with Med17 domain of Kingdom Fungi
Unable to open file!