Description | Mediator of RNA polymerase II transcription subunit 18 |
Sequence | MSSHHYEVALFGEFYPQDLSAVMNRITLHGESAHPMHAREIVFEQTRFTNEPPSHREHGQEPPLLRARKDLLEPDAKWVLYSYLKPESARVHPEATVRPWATCQVVGNALHFASALGYTRRSQIYKRGYVFRRGPLVIQMFQQEQVDPKTQKPITAHPDTLWEVEVRTAAPVRNTQETPLSRYIEAVLEVQLLMKGLLDLRRQDV |
Length | 205 |
Position | Head |
Organism | Fomitopsis pinicola (strain FP-58527) (Brown rot fungus) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Polyporales> Fomitopsis. |
Aromaticity | 0.09 |
Grand average of hydropathy | -0.523 |
Instability index | 45.98 |
Isoelectric point | 7.95 |
Molecular weight | 23732.80 |
Publications | PubMed=22745431 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364150 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP32554 No repeats found |
MoRF Sequence | Start | Stop |
1) RGYVFRRGPL 2) WVLYSY | 127 78 | 136 83 |
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