<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32550

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMASVKPPSTPQDNTGSTLLAQYPPRITLDSPLLASAIPLQESPLIAYAVFSGGSSTGADNLICIEHARRSVLARNTGCDILSSLLPAVHISRDTAALFVFAFGSSHQNSGGTSALAALQLEDLIRVESSTFQPSTVYPCSAACSTQEIPCPRCLDPTHTPFPASSAHLLPRHALRLPFHYFLTAVRDRLIYDITKASTCDRSHRPAVRYKDGFLLSPSPASSEWGVNWEHPTPLRPLIYSSLKVQLSHCGPHAQLLIHTVLSPTFYLPLHEASSLPSGTPIVLLPYGVPAYYLNTYSGPTSALTSQFQDALFGLGAGDWVGDRLPPAHQNGPGPAVGKEGPTYVIAWLSVQNKQGEDKGMPIVWPLRLCLSYHPTSPSPHSHTPLSHIPELPTQLQASPPPVPNVPTAFATGKGETSSSATHSRGGTPSQGAEAPRDQGLLPATIFRRPAVHRSSATVDSLRAFQGMTLIPTPSTRSLHAVVGQVSGFVDVVAKERERERERIKREKENTRARTSSFSGVPASSTSPRDIVNTQPLQPAAQPEPAVEPAVTIEVLTRLDEDSPMEQDAEPLFPSSQDSSTDSLFSPADEGSPLGAGSAEHTTAEVTSEPDLETTVPQPPLSEPHAEAPQDGLAAFDPFAGFADGVGSWVGPSSSDFMGVDMSLGTGYDMGTFDNSRSGAGIVGDFEMDDSLGVFTDEDFNFFDAPSSHTRIAAPLMTTSIDNAMKAGEGLTPTAGPAPLGFSPQRLGDAITSSGPGPPSASFSGRSPWPPALVIDDVASRLFNPFTDSISPAPELVPPSPTRSTSTQSAPATPRVEIADTQDSVQHKDRYLGIGPSIFDPIPFAPGHQITDGKYAFGKFALPSPSDTEDRAEDVNLSHNGNWMLKYNAATDPRIGMMKKLIGVKRKSLGHTRDSATPTWLHEHEEWERNESPPFADDDSKSDSESDGDSDGVVAADDEDMVMTLRPSTPPPSYLPLGPTLLETRFHHDRLLPLSGPLRPPGAAVSNTASGPAPVSAPTPVSPAAVLGATSEKSKSLEAAVQILVKEIVENSVWADAWRANAAASSTSLKPPYEVWQTDVKRVARLLQCNKACQSPVDIARYHHPGTISHTISLYPLEPPLLTIAKSDTLIQVLPASLRFWKKLGLGPRAGRKDVTAFVFYEGTSDRKESEMCQWLSKLSSAYSAKNCGTHLQGTAAMCSKAGLVSVQFDSFKKTLVKFVSGLPTSTETAYVLYIVTPPAVIALESPLLRQLFSAVKRCIKTYPDLRVLFHFVPEALPAGALADSRFSNEGLDAFVGVIYDRLLQPVERPVSKQLASQTGSTRAYFQSPAFSLAPALPSRKDAGAVSFAFETQPSSLDLVNRHMLFHVGYTITPCKRWLLAASVDGRGDSHDLGAWLLPDESVDAFVTKQVWTFARTCAARASVEWRVAVAKLGSLGVTELDAWIHHLAGAVGNSSEVPPMRVMLLSVEHQRPLTFLAPPNDERPSPIYHSTGISSSRSPPRGSSVHVFADVTSTTYALFPPAHVSCYPASSLDPMNGVSPGSLELSFIPDAEDAGSPAYEQPAIRGLARSMLINAPADTDYTSIGSIEIIHLHTACSSTSTNRVQHDEDDVAMVVDDGQRLVPQDVSAEDATMLRDVTHNYHALAILAQARWQPRESYGLPLHLSALEAMNMALTSGSVDTI
Length1682
PositionKinase
OrganismFomitopsis pinicola (strain FP-58527) (Brown rot fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Polyporales> Fomitopsis.
Aromaticity0.07
Grand average of hydropathy-0.216
Instability index52.01
Isoelectric point5.54
Molecular weight180212.52
Publications
PubMed=22745431

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32550
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     945.08|     138|     144|     515|     652|       1
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    5-  119 (98.66/35.37)	..............................KPPST..PQDNT..G.STLLAQYPP...RIT...LDS..PLLAS..AI.PL.....QESPliAYAVFSG...GSSTGADNlicIEHARRSVLARNtgcD......................iLSSLL...PAVHISRDT........................AAL..........FVFA..FGSSHQNSG...GTS.ALA.....ALQ
  156-  300 (135.73/51.99)	PTHTPFPA.SSAH.....llPRHALRL..........PFHYF..L.TAVRDRLIY...DIT...KAS..TCDRS..HR.PA.V.RYKDG.....FLLSPSPASSEWGV.N...WEHPT...........plrpliysslkvqlshcgphaqlLIHTV...LSPTFYLPL........................HEA........S.SLPS..GTPIVLLPY...GVP.AYYlntysGPT
  305-  460 (127.31/48.22)	SQFQDA.L.FGLG.......AGDWVGDR.LPPAHQngPGPAVgkEgPTYVIAWLSvqnKQG...EDK..GM........PIvWPLRLCLS......YHPT...SP........SPHSHTPLSHIP...E.......................LPTQLqasPPPVPNVPTafatgkgetsssathsrggtpsqgAEAPR......DqGLLP..ATIFRRPAV...HRS.SAT.....VDS
  515-  652 (228.66/93.64)	SSFSGVPA.SSTS.......PRDIVNTQPLQPAAQ..PEPAV..E.PAVTIEVLT...RLD...EDS..PMEQD..AE.PL.FPSSQDSS..TDSLFSPADEGSPLGAGS...AEHTTAEVTSEP...D.......................LETTV...PQPPLSEPH........................AEAPQ......D.GLAA..FDPFAGFAD...GVG.SWV.....GPS
  654-  787 (124.21/46.82)	SDFMGVDM.SLGT.......GYDMGTFDNSRSGAG..IVGDF..E.MDDSLGVFT...DEDfnfFDA..PSSHTriAA.PL.MTTSIDNAmkAGEGLTPTAGPAPLGF.S...PQRLGDAITS................................SG...PGPPSASFS........................GRSPWppalviD.DVASrlFNPFTD.....................
  788-  911 (136.16/52.18)	.SISPAPElVPPS.......PTRSTSTQS.APAT.....PRV..E.IADT..............QDS..VQHKD..RYlGI.GPSIFDPI..P...FAP...GHQITDGK...YAFGKFALPSPS...D.......................TEDRA...EDVNLSHNG........................NWMLK......Y.N.AA..TDPRIGMMKkliGVKrKSL.....GHT
  938- 1040 (94.36/33.44)	DSKSDSES.DGDSdgvvaadDEDMVMT..LRPST...PPPSY..L.PLGPTLLET...RFH...HDRllPLSGP..LR.P...PGAAVSN..TASGPAPVSAPTPVSPAA...VLGATSEKSK.....S.......................LEAAV..................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.53|      29|     118|    1113|    1141|       3
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 1113- 1141 (51.15/29.40)	LYPLEPPLLTIAKSDTLIQVLPASLRFWK
 1232- 1260 (49.39/28.12)	LYIVTPPAVIALESPLLRQLFSAVKRCIK
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32550 with Med13 domain of Kingdom Fungi
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