<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32549

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMPGMLMDGLGDLFEDNASTARGIHELMDRLRQGGCRQRIAWGKLGCIASIAANGIDVEIRHLMASTKDGSWILSPKYLIKNIHNGAPLSSVHWNNIGSELAVADIYGRMAMWTVFVSVDRLNPLRQSTATVKDDLNMLAGLWWLNMNKPYALSKSAMKQDGVYKYPTNSLPPMGPLNPIQGRTACLGVTKSGVVKLWYSSDGQSHIQKATADLEPYTSMDDIITHAAFAADKVIDWKHPPLPPGANVAQLPIPVSIHIKRLKIEHCPGDGQDSATSFLTHLEVLSPFPGNHTQYPIILGFFVNTSAQQYLTTIKRWELRNVGTSLHSSFDGLAQRRNSTVTEKERFELISYPDVTLHKCALSVTQINASTMIAVTYTDGTFEMRDRMQFNSVQPTSNYDKLINMIHAGWHFPLLGPYMDIVLSPNYAAAALLTKENDVNLVLMTHHDPLEGTPEENPNVLIAAVTLAQQHACSSNNHSNNDDLAAVARQYNNNHFKTCVLLESHRSLNQNIDFLQEQSNEKLQRNPFFQRCLSLQSALYYKGWANPKPIPAKISQATLHLKATSVGFGYFMNNVARNRQDLEDSKSNALQNLLGVVKWEIDFHVYLVDELLELARRVRSNPGDMELVKKIINDTNSCALPLILTGASRFLLKYNSRALRGFDQAARDHLAQTTVDEALKQGFQSLRTIMDANPVKFNMFEKLLVDTISGIKKTTEEWDPQKRIDVDRMIFLTGEIPTVFYPIVEKFLQHSLGILKNDIDPSSIFFFDTTWLGFHDDRKSVEFKKGEKVDTLRKCLLKKGTATRRCLRCGEVVEDLVPTMRMGLWLQSVSRVCLCGSLWMHDE
Length842
PositionTail
OrganismDactylellina haptotyla (strain CBS 200.50) (Nematode-trapping fungus) (Monacrosporium haptotylum)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Orbiliomycetes> Orbiliales> Orbiliaceae> Dactylellina.
Aromaticity0.08
Grand average of hydropathy-0.248
Instability index40.37
Isoelectric point7.62
Molecular weight94630.40
Publications
PubMed=24244185

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32549
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     144.18|      48|      66|     302|     367|       1
---------------------------------------------------------------------------
  305-  356 (75.86/85.05)	SAQQYLT.TIKRWELRNVG..TSLH..SSFDGLAqrrnSTVTEKERFELIS.YPDVTL
  369-  422 (68.32/36.47)	STMIAVTyTDGTFEMRDRMqfNSVQptSNYDKLI....NMIHAGWHFPLLGpYMDIVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.61|      26|      70|     152|     179|       2
---------------------------------------------------------------------------
  152-  179 (45.10/30.64)	LSKSAMKQDGV..YKYPtnSLPPMGPLN..PI
  223-  252 (40.50/21.57)	ITHAAFAADKVidWKHP..PLPPGANVAqlPI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.37|      33|     149|     505|     546|       7
---------------------------------------------------------------------------
  505-  546 (42.89/55.54)	RSLNQNI.DFL.QEQSNEKLQRNpfFQrclSLQSALYykgwANP
  659-  693 (50.48/32.24)	RGFDQAArDHLaQTTVDEALKQG..FQ...SLRTIMD....ANP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32549 with Med16 domain of Kingdom Fungi
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