<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32546

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMELPEICLTNVFKIENLSEISYSVYRISSTLGSAPAWRVLSKAETNLRRLGKCVTTCSEASELWLFQLDSNDVDITLASDSGYNSYDGSGTSEKGWEPLVWGLEEKTKDILHIHELFEIVRPSPPEKPEDLITLQPLPPLDPTVSPGTQLDPIDLSGTHRDVFMLQQLSKQRASTMSAVSSPVTGSRHGSSATSTPRPAATRPISKQEIVAQKCLLAMMSLLSYRLASSFSWIPLNLFTFLPNAHNGKADRHITSDASPNFYAESPLDDGSDILSYSPVPHGPPLLTTISLSLLDDGSLHIAPKTITQSAIQRFSDVKISESREEDVWLAPGGIIGRHTPKPNPDSLSQATPEWKAYVLKSLSDRGIELENPGSTTWAKVGVWSDIEGLVDIYWPTYLIFVRKYAEQDALSRPTDISVNGIASTKDSAKDMDNLARQLTWYNAGDSLEFAESWLAGIPSREAERKRRLEARNKAIPLMEQERKPAFIAPTTDRSGTVYPTPPDGISGNDGHPTPGGPQTAPTPGQTKVMEEPIAAVIEPPTAPPTTEPTVNSAEMDLDDAWMKDADTSKTGDDMFGGVQDVGMEDDLFDITEDDFGFFDKIGGTDDFAEITLEKPEIPTEIQPRPTTSALSENMNDLNLGFSALGSYADDKLALVDMDLDLDEIGAAMDMQAEMQSYEGGPSNTNGMGSQTTNGKGMSQNGQGHNLSQNQSQSQDSQNAVVQVETPPLSPQRAMKLLLLDSDSAKDTLIPDIEGLTVSRTRRKSLYSPVDFPSFMERSDEKYMAGGRFFCAEDDSTPKHKSPEARKFSATFPRIKKYRNTGRPLSRDIMFIDDDEERSDLIPDTGSSDEESTTTDEYESGDEEMFEISNEGGPDTSSYSTSLSPEGIRQGLKRKRTSDRDYWGGSNKLQGVEALGRPDKRNDIDTAPEWSTDMVTLNDKDIDNLSTAQRTLCDFNQSDLSLDGVFTFVPDNDEISNRLSSQDLTHIISLLQEQVVWNTYLISMFNPDNPSAGRISSVEIDANGMHEPAERTFHLRQQSMRLQDDIEDLLSDVFGTLASRCSLETLVYGVLGRPKNSIYGVSPCVMDVHPLSTGLTPINRPKSSSDVGPSLLFRISPPHVHVHRNATLPNSAIELLPPALHFWDTFGLAPHSGPKDMLMACIFPTESGLTNSAKAYLDGISTTYESCRLGETLPVKTKLIVDGLHAIPIQDKAQNVDKKTMLRRFCEGIIKMAETLVEIEDELQNVVLFIVNPFDAPSSVLDICVAFHMLKKAYVNALNSSLRVYPNNLILQIVPLRNVATYDGLAAQSHNQSVRCALEVYERCTQTIQDHLSQTFPQETYSPSLTLAKVPPKSIAFKVSADPSPAILQENMCLHIAYAQSIDERWVSVAWSDDCGEIKEVFNFCLGIPGTVILRSFDDICKEIWSATNKIISKKRVHWRISLVKVGAIDDDEIDLWTKFSTDCAVPNTLTIFSSDPSPPLTFRYSIPSISPHIFHGQAQLVGTPGATPQSSGVSPDQFGASSQGGALTPGDTPGPEIDNDFALIDYTDETWGALIQHPLNNADSTIKTRPALASGYLIKRTGPNETDDPAILAVSLIRPGQRGSGAPPQSLAVSKTNEDVLREVLTQYRGLVTLAQHFGVIDMMKEVLPWHIAAVVKCRDAFSCVL
Length1666
PositionKinase
OrganismDactylellina haptotyla (strain CBS 200.50) (Nematode-trapping fungus) (Monacrosporium haptotylum)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Orbiliomycetes> Orbiliales> Orbiliaceae> Dactylellina.
Aromaticity0.07
Grand average of hydropathy-0.370
Instability index48.86
Isoelectric point4.75
Molecular weight182918.20
Publications
PubMed=24244185

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32546
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     120.47|      24|      24|    1485|    1508|       1
---------------------------------------------------------------------------
 1076- 1100 (39.61/21.44)	SIYGVSPCVMDVHPL.STGlTPINRP
 1485- 1508 (45.16/25.59)	SIPSISPHIFHGQAQ.LVG.TPGATP
 1511- 1533 (35.70/18.53)	S..GVSPDQFGASSQgGAL.TPGDTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      78.08|      17|      17|     575|     591|       2
---------------------------------------------------------------------------
  558-  570 (16.57/ 6.92)	....DDAWMKDADTSKT
  575-  591 (30.97/20.19)	FGGVQDVGMEDDLFDIT
  595-  611 (30.54/19.79)	FGFFDKIGGTDDFAEIT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.82|      16|      16|    1580|    1595|       3
---------------------------------------------------------------------------
 1580- 1595 (28.83/14.74)	RTGPNETD.DPAILAVS
 1598- 1614 (25.99/12.51)	RPGQRGSGaPPQSLAVS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     157.39|      50|     611|     133|     207|       5
---------------------------------------------------------------------------
  152-  207 (76.70/84.00)	PIDLSGthrdvFMLQQLSKQRASTMSAVSSPVTGSRHGS......SATsTPR....PAATRPISKQ
  768-  827 (80.69/38.98)	PVDFPS.....FMERSDEKYMAGGRFFCAEDDSTPKHKSpearkfSAT.FPRikkyRNTGRPLSRD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     269.68|      60|     611|     336|     395|       7
---------------------------------------------------------------------------
  336-  392 (88.49/47.42)	.........G.RHTPKPNPDSLSQATPEWKAYVLKSLSDR.GIELENPGSTTWAKVGVWSD..IEGLVDI
  901-  963 (62.24/31.13)	YWGgsnklqGvEALGRPDKRNDIDTAPEWSTDMV.TLNDK.DIDNLSTAQRTLCDFN.QSDlsLDG....
  965- 1003 (51.59/24.51)	............FTFVPDNDEIS...........NRLSSQ...DLTHIISLLQEQV.VWNT..Y..LISM
 1004- 1066 (67.36/34.30)	FNP..dnpsA.GRISSVEIDANGMHEPAERTFHLRQQSMRlQDDIEDLLSDVFGTLASRCS..LETLV..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.49|      15|      19|    1116|    1133|       8
---------------------------------------------------------------------------
 1116- 1130 (29.91/21.94)	PPHVHVHRNATL.PNS
 1136- 1151 (27.58/11.25)	PPALHFWDTFGLaPHS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.74|      23|     400|     122|     146|       9
---------------------------------------------------------------------------
  122-  146 (40.37/23.87)	PSPP.....EKPEDLITLQPLPPldPTVSP
  521-  548 (38.36/17.17)	PTPGqtkvmEEPIAAVIEPPTAP..PTTEP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.60|      14|     400|    1227|    1260|      10
---------------------------------------------------------------------------
 1206- 1225 (16.79/17.32)	IPIQDKAQNVdkktMLrrFC
 1236- 1249 (23.82/25.70)	VEIEDELQNV....VL..FI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.20|      14|      17|     636|     649|      14
---------------------------------------------------------------------------
  636-  649 (23.87/15.79)	DLNLGFSALGSYAD
  656-  669 (24.33/16.26)	DMDLDLDEIGAAMD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.91|      21|      23|     834|     854|      15
---------------------------------------------------------------------------
  834-  854 (36.79/24.67)	DE.ERSD....LIPDTGSSDEESTTT
  855-  880 (28.12/16.56)	DEyESGDeemfEISNEGGPDTSSYST
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.37|      22|      29|    1370|    1397|      16
---------------------------------------------------------------------------
 1370- 1397 (37.14/35.76)	NMCLhiayaqSIDERWVSVAWSDDCGEI
 1402- 1423 (41.23/24.86)	NFCL......GIPGTVILRSFDDICKEI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.73|      17|      17|    1534|    1550|      17
---------------------------------------------------------------------------
 1534- 1550 (29.92/17.51)	GPEIDNDFALIDYTDET
 1552- 1568 (28.80/16.57)	GALIQHPLNNADSTIKT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.22|      11|     369|    1103|    1113|      18
---------------------------------------------------------------------------
 1103- 1113 (21.22/ 9.46)	SSDVGPSLLFR
 1473- 1483 (23.00/10.92)	SSDPSPPLTFR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32546 with Med13 domain of Kingdom Fungi
Unable to open file!