<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32544

Description Uncharacterized protein
SequenceMSTVTKPRQQRTAGGTGGGRRPSQPHTGPHPSPLVIPGATAGSHSHASTPTSSQSSRVSHSRQSSKSANVIDLTSPTLPTPVRSRGRSSSIAKSVAASPSVLRSAAQEAFPPNMPAKGPLAVTNARKRPRYAFPFPTTAQQQQNSHAPFLLSFSSQPSIELKVIPQPNKKPKRSTRQKVAPQPGTQVAPRDNKLKSYMIEPPTGCHSYPFKDNSGKELKEPKYPDFFPWRGNHPEDHVTESAARTGFSDKMHPGEQGSAKNLLAPLIKKNVSVDIVSSLFVTILDKRQHIGRITAPSTFKFPPRVTFPGQRREIWLRDLANPTIPLRKVSRTIPLGLRGKELLDEYTSKNVPLLRALWYVRCVGANEIRSLKRKGAGSLAIGNESKWPREWTQGVIQYIEKGMADFGKEVAGTSSGPKGGWKTRMTYILRLTTQLYLEGLLDRSQFLEWYLHFLETCSLDRLPVTLLILQMAWDHIVSSRKFGRRFVDALLGKVKQILATKEVDIYKPLLQRLSVHLTHLVLSHRQAFVNPKSWAINEQPLRACVDTRNPTVLASISNIAARNRNLEARQASKSGGAGGSTIASPRKAAIDFLDKIRPPYDIEEVTGRFLAISKDYHQTVKALCEWAITSLRVGLHRLYFAVRLLRRLSKLGVQIQPPIHDFLLAIGAGRRSKKHVYLLISELVRSRHFTAGKYMSWLISRGALMRHGSVDEEQPCYIRLLAEIPVNHHHTPSAQRNLRSNLLLQKGFLVTIEAASLARAKEIIADRIPGIFSTPSRPTTKPESAFTFDEISTLHGLTRNVMSELGFWICDAVRKRQQQGTAAGNANAHAIGWRASVAENANGGVSPAEFLLVRKILEELEDYGVLAEVIKLVATSENPEMLSAAADTISSNVEVYFAIGVVGDTLKSLFDRYKALQVKRTMEHRPVEQYLTTSLFNFAQYPGCDAEIRQSLESDFVLGRTHSMQPHSVLADTLESFGDGELDAGVEELLSGTVAATPMLVRKAFEVLIESVDAGFRGTDMATIKRFPRLLSILRQIDAATFDPLMEAWMVQTIRSSTRPTLAVAFSNMLVAGCFELKSVVRVTSEIIGQFGEESGGSIEAADVTELAFQTLALLLDEEDGRMDLEEQEMYSLRLERKRFRAMNGKLFVSIFRKAIKLCVAAADPNLERRLEDSMNNDIVLDLLRNLAFSDFDMLVSELVEPLAPQSNPLISKYLSLLIDHLLDEHDSNDISEVDADVQVARLLQHVNDFSVRLCQLKMRLIFEAEISHASDTAESANLRNAVTKAFVSSITEMNSDRGAIWADLVSVLDDACVSQIRVYTEEMVLNAPGFPNAATSFMSVDEGSDEEGMKRASEMLAKSLISAIDVTAGSGRGSGNTDSGTWLPPVLADKITIVLQNLNGVGGEVAIQSDGEVTGKEPGKKGYARLRSWIVLFLRIVALHKAEFASPKTSAIEQGRIVIGLCALLENKFIQNDDFVFEFALDIACAIVDDMNEESRQHIRRFLKRRYDLPQISYLLGGIEVWNVGHSDARAAAASAGAPTGSEWLKGLSRGRLVDYPLKAWEQVSDPTPVAGDNDTSLTHESTPPPLGPALLEAPHELTFVRLIKSTLTGNTVAIIATILAILSLAWGIYQSRLASISNDYEAKSYDLAVWDTCTSSTDPAVTDSKKCKTILLKGFDALEKRGPPVSLLPPASPSTHGKGIRKGVARSLMEAAELQVVRRIKYIVQFSLFFATIAIRNEFYQILPIVWYRYRTSRYCNAFILGTLIGFAASMGIWFAPFIFQNFVASLTFGNALHCLVCLWFQNPAYKFGFYCVVGTNPLQVYVNFVVFMVPLIRRSVPFEFTVRRFRLEWASVENKNLADLGFSAVIGALVLNCGRYLVMRALVKFAVRDPESTEYLEGGLKKAGGYILFIFSLM
Length1917
PositionKinase
OrganismDactylellina haptotyla (strain CBS 200.50) (Nematode-trapping fungus) (Monacrosporium haptotylum)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Orbiliomycetes> Orbiliales> Orbiliaceae> Dactylellina.
Aromaticity0.08
Grand average of hydropathy-0.117
Instability index44.34
Isoelectric point9.17
Molecular weight212172.30
Publications
PubMed=24244185

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744
GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP32544
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.37|      11|     580|       8|      18|       1
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    8-   18 (21.64/12.90)	RQQRTAGGTGG
  569-  579 (20.73/12.01)	RQASKSGGAGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.16|      28|     580|    1027|    1077|       3
---------------------------------------------------------------------------
  979- 1006 (47.72/38.95)	DGELDA.GVEELLSGT.....VAATPMLVRKAFE
 1043- 1076 (40.44/31.85)	DPLMEAwMVQTIRSSTrptlaVAFSNMLVAGCFE
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     149.49|      48|     580|    1244|    1331|       5
---------------------------------------------------------------------------
  716-  766 (72.10/37.51)	CY..IRLLAEIPVNHHHTPSAQRNLRSNllLQKGFLVTIEAASLARAkEIIAD
 1255- 1304 (77.39/103.31)	CQlkMRLIFEAEISHASDTAESANLRNA..VTKAFVSSITEMNSDRG.AIWAD
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     255.58|      81|     512|     630|     711|       6
---------------------------------------------------------------------------
  630-  711 (135.23/121.69)	SLRVGLHRLY.....FAVRLLRRLSKLGVQIQPP.............IHDFLLAIGAGRRSKKHVYLLISELVRSRHFTAGKYMSWLISRgALMRHGSVD
 1132- 1230 (120.35/101.68)	SLRLERKRFRamngkLFVSIFRKAIKLCVAAADPnlerrledsmnndIVLDLLRNLAFSDFDMLVSELVEPLAPQSNPLISKYLSLLIDH.LLDEHDSND
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.60|      11|     172|      24|      34|       7
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   24-   34 (24.39/13.14)	QPHTGPHPSPL
  200-  210 (25.21/13.85)	EPPTGCHSYPF
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---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     146.38|      46|      85|      50|      99|       8
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   50-   99 (68.55/55.19)	PTSSQSSRVSHSR..QSSKSANVIDLtsPTLPTPVRSRGRSSSiaKSVAASP
  136-  183 (77.83/50.10)	PTTAQQQQNSHAPflLSFSSQPSIEL..KVIPQPNKKPKRSTR..QKVAPQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.27|      15|    1207|     465|     480|       9
---------------------------------------------------------------------------
  465-  480 (24.01/20.80)	TLL.ILQMAWDhIVSSR
 1619- 1634 (24.26/14.66)	TILaILSLAWG.IYQSR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     141.84|      48|    1207|     285|     334|      10
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  285-  334 (79.02/56.55)	DKRQHIGRITaPSTFKFpPRVTFPGQRREIW......................LRDLANPTI...PLR...KVSRTIP
 1495- 1570 (62.82/36.12)	ESRQHIRRFL.KRRYDL.PQISYLLGGIEVWnvghsdaraaaasagaptgsewLKGLSRGRLvdyPLKaweQVSDPTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.56|      24|     116|    1592|    1616|      11
---------------------------------------------------------------------------
 1592- 1616 (35.73/33.29)	LLEAPhELTFVR....LIKSTLTGNTVAI
 1710- 1737 (34.83/25.59)	LMEAA.ELQVVRrikyIVQFSLFFATIAI
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32544 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ELKVIPQPNKKPKRSTRQKVAPQPGTQVAPRDNKLKS
2) MSTVTKPRQQRTAGGTGGGRRPSQPHTGPHPSPLVIPGATAGSHSHASTPTSSQSSRVSHSRQSSKSANVIDLTSPTLPTPVRSRGRSSSIAKSVAASPSVLRSAAQEAFPPNMPAKGPLAVTNARKRPRYAFPFPTTAQQQQNSHAPFLLS
160
1
196
152










Molecular Recognition Features






MoRF SequenceStartStop




1) LAVTNARKRPRYAFPF
120
135