<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32537

Description Uncharacterized protein
SequenceMIPHSSAGQPWAYPTRDPNGGPVRVDLAQAAGHFDSSSAVSQQSAGPMPSQPAARHTSSVETSSTGSHDRGPLLKRPRLDLSGTSNMSDGSSAMPSAEPRSTPTGTGSRPQLSWRGRPSWSFQSVISEIPGHDHRSSEHASGSKPPSPPPFPAQLWISDPAERQPDADSEACDPPPVKKVSTTPYRIETPAAAPILKGDKVAGFAPWTGKHPEDILNEQTAKSGYYDRTQVSQNESNTARPALYAQLKHRTGLQMLSTVFTAALEKRQNHSTVHAPSTFKPPPRVTLTDNKREAWLRDLANSTVPLRRLSRTIPHGIRGKVLLDQCLSKWIPVARAVWLAKCVGANEIRAFKRKGTSGALATGLEAKWVREWTTNVQQFVEGVFATPKVTDWKAKMTYAVGLSARLFFENLLDHEQFLEWFLASLEAASLATVPVWVLMLGIYWDNIMRFRRRGRRLVEILLEKLRQTITAKIDALRPLLDRLSRFVRKIAHEHTSSMIIPVSWDVYKDCIRQSLDLSNNVDRALLQNIAERNVRVQRPRNSQRSSQVSSHQHQRIVRLFDSIQSAHDVLTVSAACFEALGNGLALVSKLLEWLATPFRHGVRRVYVGVRLLRRWKACGVDVDQHILCFLANAGVNKKIDLENVYHTISELVRSQTFSVGRYLQWLMAKGAPSRQIDDNVPPVNVAGDVELITQLPVCRLPEHVCNLRRTLMVRTGYSATEEALMIESIKTAITHRLPALFNLSMPLDNVPQSLPTSLPWSVKAEVTQWLRRCVVEHTRVSTCVPQSSLPTLSSQISALTPDEFYLVRDILEKLGDISILADVLNVASSSDDSIILASIADTIHCHLDVLLVIGAAMDLFRKVVGAYSNVKRNGLPSLDMIFSLIELGLRMPSESHTVAILRQDLLRLENRSVVAACSPVSDHIPDSLGDADPLLREKLDHLLYVGNVIDEPTMEALFQSLTKHLEGDDGKSSLSANDTCRYLAQLRSFQPKHFDVTLARWVCMRIKSSDRSHFMRVLPPLIGVGCVTIRSFWSLAKRLSASANTILDAADLPTDLLGLLMIEDRGAPFLDLVSYRFEMSRQQFISNNTDMILSILYDATASLSGTDKVATAKYTELENSMIGLLVELLMRNPTTSSQFCLERIESQPVVFTSVVRKALDVLLGSSSQRGQQSVIEEVEKLALGADEFSLPLCQLRLQIIFQMQSTPQDRSKLVDAMFRTVVAGSGAQRPPWIDLVALMSSDSVRHIRERAEKEFLAIPLLEEPILSEGIKNLNAARLYLSVIEQLASSIPDSGVPTIAPLIVDKLESLLHKFVAIQSSQADNRGAQSAAHDCHRDSERLLAFWFSAFCKLVIIHRVSFAQTASALKVGPSPEQPRLLVLLLSIALCRLPNIMSSGPSGADNSPHQGAGSGGQTCPAVPLQTYALDLVASLVDVFPDEARHQCARILKEKCPPFAALQDDSRFVYLLGPIPDINTSGMVQATSAQSPMASASTPTAVPATSSNARDAAQTPSVNANPGFSENPACITNRLRLEHRGRTIGPYPVRPWELLEDAAPFVGLNDTAVNLGYFDARRVRV
Length1576
PositionKinase
OrganismPenicillium oxalicum (strain 114-2 / CGMCC 5302) (Penicillium decumbens)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
Aromaticity0.06
Grand average of hydropathy-0.139
Instability index51.31
Isoelectric point8.60
Molecular weight173753.00
Publications
PubMed=23383313

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32537
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     553.26|     218|     240|     819|    1057|       1
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  819-  931 (97.48/86.96)	............................................................................................................................................I...LADVLNVASSSDDSIILASIADTIHCHLDVLLVIGAAMDLFRKVVGA.YSNVKRNglpsldMIFSLIELGLRMPSESHTVAilrqdLLRLENRSVVAAcSPVSDHIPDSLGDA
  932- 1166 (331.43/252.09)	DPLLREKLDHLLYVGNVIDEPTMEALFQSLTKHLEGDDGKSSLsANDTCRYL.AQLRSFQPKHFD.VTLARWVCMR.IKSSDRSHFMRVlP....PLIGVGCVTI...RSFWSLAKRLSASantILDAAdLPTdllgllmIedrGAPFLDLVSYRFEMSRQQFISNNTDMILSILYDATASLSGTDKVATAkYTELENS......MIGLLVELLMRNPTTSSQFC.....LERIESQPVVFT.SVVRKALDVLLGSS
 1171- 1297 (124.35/75.28)	QQSVIEEVEKLALGADEFSLPLCQLRLQIIFQMQSTPQDRSKL.VDAMFRTVvAGSGAQRPPWIDlVALMSSDSVRhIRERAEKEFLAI.PlleePILSEGIKNLnaaRLYLSVIEQLASS...IPDSG.VPT............................................................................................................................
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     225.98|      66|     103|      32|     111|       2
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   32-  103 (105.92/64.15)	GHFDSSSAVSQQSAGPMP.........SQPAARHTSsvetSSTGSHDRGPLLK...RP.RLDLSGTSNMSDGSSAMPSAePrSTP
  131-  206 (90.31/47.30)	GHDHRSSEHASGSKPPSPppfpaqlwiSDPAERQPD....ADSEACDPPPVKKvstTPyRIETPAAAPILKGDKVAGFA.P....
 1468- 1494 (29.75/ 6.87)	................................................GPI......P.DINTSGMVQATSAQSPMASA...STP
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.38|      31|     103|     633|     666|       3
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  633-  666 (50.24/38.94)	AGVNKKIDLENVYHTiseLVRSQTFSV.GRYLQWL
  739-  770 (53.14/33.36)	ALFNLSMPLDNVPQS...LPTSLPWSVkAEVTQWL
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     186.18|      53|     103|     330|     383|       4
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  330-  357 (29.82/21.22)	..........................................WIPVARAVWlAKCV.GANEIRAFKRKGTS
  358-  397 (55.56/37.75)	GALATGLEAK..WVREWTTNVQQFVEGV............................fATPKVTDWKAKMT.
  398-  456 (61.68/42.85)	..YAVGLSAR..LFFENLLDHEQFLEWFlasleaaslatvpvWVLMLGIYW........DNIMRFRRRGRR
  463-  511 (39.12/24.04)	EKLRQTITAKidALRPLLDRLSRFVRKI......ahehtssmIIPVSWDVY.KDCI...............
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32537 with Med12 domain of Kingdom Fungi
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