<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32531

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMAMTSSTSADQWCKFMRKCVSARLDVDKFESYARSLLPKSPLPRDDLAAVIISPEAYPTPQLSVDPRYLLYVQRLVSANIVPLSSFLHALWQSDRVQQNNVLHGAAENLAAALSREPVDTAILTSLVLVVQNPQSNTSTTNGNAGPRETPAALIDSLSKWMDAVIAANDDNGLDGLGMPSGIMGAQKKAVIGELVVSVGENPTLNGFLKTSHEISKDKRANFENTLPMFAQVFQALNPQLVVRLDSLLPKKADGGAGNGLLGIGMGLDSMGDSGAVPSRGGLYLFINSLFFARPLVDDEYLIHHLLNRYKELSGQAALDLIIAALDCITNAISRTESSSTVALFRHFLVNKIPLLLIRFNLGEIQAQYVISQALQKSGSNPLSLDPTLDTMMLDLPNDIKQEFLFACALHMIIEEASVEEILGDVPLQTMAKQRYTQEDLVTECMMDQDRLERLINEIEELDGNSGAIVGAVVEMLQLMCDQKDTMGLYSLCKNLISRPETIDLLFLYARPVSILEPLCMVLENWRYDDDQGEYEPVYKEFGHILLLILTLYHRHTLSFSHLGPSISATSFVPMFIQSCHKDIAIDDLSRMGERHAQLGGWIKALYEGDGITDEVMQSCRPQEYYSLVPTLIAQTVEACERGVLDTETLKGGLDYFQLSSLIASEVAIIFWLTDYIWTHTTTQQGDISHALKILHILVTNAPSEVTQTHKTILAICAHNLERVLKDIGRSDGPTAGGNASNNSAANHQQAEQILKHIAHYRDFRRSGLPSASELDGWAKQNGGVLAALKNAVQGVIMWSATPDLSIQPAGWTPRIVYAAWRMLGAKEVVKVLVDEVLGLTSAGGGGGGVAAAATAGEGIVDVAIDVVASLIVAPVMEDWKFKVMEVTGKKEDVTSGTTGGTASAGTAGSGGYVSLVEALRYLEDDCKLSVEDQGRSEVVVKIVRKVESLIAPPTVTAGIAGAAATVNDLANEVLGDVMADSDMFQGMPDPVDLGLTADDIMTGM
Length1004
PositionTail
OrganismDactylellina haptotyla (strain CBS 200.50) (Nematode-trapping fungus) (Monacrosporium haptotylum)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Orbiliomycetes> Orbiliales> Orbiliaceae> Dactylellina.
Aromaticity0.06
Grand average of hydropathy0.053
Instability index36.02
Isoelectric point4.82
Molecular weight108698.07
Publications
PubMed=24244185

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32531
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     110.82|      40|      66|     782|     827|       1
---------------------------------------------------------------------------
  796-  858 (55.14/42.52)	IMWSATPDLSIQPA..GWTPRIVyaawRMLGAKEvvkvlvdevlgltsaggggGGVAAAATAGEG
  862-  910 (55.68/27.20)	VAIDVVASLIVAPVmeDWKFKVM....EVTGKKE............dvtsgttGGTASAGTAGSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     145.09|      50|      67|     296|     351|       2
---------------------------------------------------------------------------
  296-  351 (63.51/60.49)	VDDEYLIHHLLNR..YKELSGQAALDLIIaaLDcITNAIsRTESSSTVALfrHFLVNK
  364-  415 (81.58/51.58)	IQAQYVISQALQKsgSNPLSLDPTLDTMM..LD.LPNDI.KQEFLFACAL..HMIIEE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     141.57|      44|     134|     444|     498|       7
---------------------------------------------------------------------------
  243-  289 (70.57/35.58)	RLDSLLP..KKADGGAGNGLLGIGMGLDSMGDSgavPSRGGLYLFINSL
  450-  495 (71.00/64.31)	RLERLINeiEELDGNSGAIVGAVVEMLQLMCDQ...KDTMGLYSLCKNL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.43|      28|     173|     581|     611|      10
---------------------------------------------------------------------------
  581-  611 (47.15/39.86)	KDIA.IDDLSRMGERHA.QLGGWIKalyEGDGI
  755-  784 (44.28/28.62)	KHIAhYRDFRRSGLPSAsELDGWAK...QNGGV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32531 with Med5 domain of Kingdom Fungi
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