<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32530
Description |
Mediator of RNA polymerase II transcription subunit 6 |
Sequence | MASQSAPMEEIIWRSPQHVQMMGGYLHSNNILFYFAESPFFDPQSNNGTLATQATYNESLRHVVETRATFEGKLKQMQGLEFLVSFDPLEAAARSNPNRFDFEPNNIWVIRKQERRKRSGMEDEVTVLATYFVVGDTVYMAPSVASIVGNRILTAVTSISRLMKTASTLPIFTPSTGHTYLPPTARTTESGQQPSQPSKENTPMPDAPQPSVAETQISGKASLGVSTGSSSYQDIRNLAEAFRLFNQYGDEFMDEHPLTGEPGSFILSRAGETDRPAGAAAKVASKASLGTGVNTPAGIRARSTTPQVRIDTPGKLSDKGNTPPSSVENKLKKKKGRVVS |
Length | 340 |
Position | Head |
Organism | Penicillium oxalicum (strain 114-2 / CGMCC 5302) (Penicillium decumbens) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes>
Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
|
Aromaticity | 0.07 |
Grand average of hydropathy | -0.481 |
Instability index | 48.29 |
Isoelectric point | 8.96 |
Molecular weight | 37021.18 |
Publications | PubMed=23383313
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364143
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP32530
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 96.60| 25| 48| 262| 286| 1
---------------------------------------------------------------------------
262- 286 (42.34/27.41) PGSFILSRAGETDRPAGAAAKVASK
290- 305 (16.93/ 6.52) .GTGV.......NTPAGIRARSTT.
313- 334 (37.32/23.28) PGK..LSDKGNTP.PSSVENKLKKK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 111.17| 32| 49| 175| 208| 2
---------------------------------------------------------------------------
175- 208 (54.29/39.73) STGHTYLPPTARTTESGQQPSQPSKEntPMPDAP
226- 257 (56.87/35.36) STGSSSYQDIRNLAEAFRLFNQYGDE..FMDEHP
---------------------------------------------------------------------------
|