<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32521

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDFPGGATTNIHLINGFSTIYWRIYTEESGIASHPQEGPANGYTILKHLGRLKHLEAQLRNIGCLASCPRRLGLWVFSPTPVFSKLSPVYIKEGDVETTKISVDTTTLKVSASGSINCSELIRGLSTDAQSQQATQPAPQRTPQGQSSGRRSDGYSSSVAIYAAFIAAVTGALSLHIVQKHGALPLGSRTLFTPVNSFGYEDAKIDSQSIFSSSKLTTLNIQLNGPGTLTVSLQTTDQPGITRLQSPGDDSADLLRMQPGTDIWLCPNGAIARLAAVDVASPSLPSPGLHASGDLVAKRRNWKLDVIRWLKDFGLHVGAIEEEPWVEVEVWEPFFARLAGESMRQGDESHPTLPLKRMLWPARFCFRRRMSLQNSLAPEASSIDPLDFAETWLSTADALTNRPAGQDVQTIDATTKNEENSPLIDTGDNLESLSRMAQYPDFSGASIVYPTPPEGATTHGIHNLTGHGISPSDPNILSPEVPHESKSQKMPEFSPKIDIGTGRYDASDDDDLFGEMNEKDFGSKGITDADFSFFDEPDQENMVDAMVVEQPQDVPEESVTFLPGNDDQDIGESHQAASTNEIPEAMVMNHGSQHEPVSQNVKDDLTPADGDMKQESSRPVSPRPSGQTISPPLSPVEIKKILFSGLRPNQGRSNQQDPEPRSDYQPIDFEQRLSSWDRKYRNMGKFWFSVGGLGNDATGDLTSIPTVGMPKLTRHQPLIKHDRGHKNDVGESGEEDSTDSAENSSDEDESGDIVPVEPQPAPVVLSLLKRKRVPSDADVQSTASPAPSATPLDAGVGPKAENTTFLGNFLSNFSDWNYTGYFSLLQNQQFPVLLRREEQIPIAQLLIDQVIQSSLKHSLCEQGDVFALENEGPSLAEYLEDVSFLGDIQKLDLRGYSCLQEEVVQSSSRNQTSFKDSSRASISKLPAPHLRVRRGKGWLETLPPAMSFWDTFGLEPAFGPKDITAYCIYPRALRRVADAFLERFGLSYESCHFGTHTRADGSLGFDNGLKAWDPESPGYAAMMQSLLAICEEMAPGLAKATTTSKHNSVVYIINPFPCAAALADICAAFWNLFRQMVSNVDQRHDRRVNEVVLQIIPREFITEPDSMAVATQNDYVNLALEVYNRCRPMTMESSPFQSAPAIILADNLPKSIQFRLASDKVSPLQEGRSLHIACSKSCDQRWVSVAWCDGTGSLQTSTAYCLRYRNRGSARAISEVRNEIWATTKHLLDKFQGRWKVVLASTDAMDLEEIEAWANLADQQNKMRPHSLDFTIVAVNIMSDLVLGAPFSPMTTGMFNNQFSSTPVTTPNPNTTSIASPDQMWNVPTPHAMFNPSTPTDPSLEPESDVILTDVYDDSWAVILSHRLNASPHITELRPALASGYLLRRKGAFDSDGVFALTTNLIYSQRPAGSHEVLLGDVLAMYRDLASLARARGMRSVRDNTLPWHIATALRAQELLSYIF
Length1460
PositionKinase
OrganismPenicillium oxalicum (strain 114-2 / CGMCC 5302) (Penicillium decumbens)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
Aromaticity0.08
Grand average of hydropathy-0.380
Instability index56.11
Isoelectric point5.06
Molecular weight160503.07
Publications
PubMed=23383313

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32521
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     400.68|     105|     176|     159|     263|       1
---------------------------------------------------------------------------
   63-  152 (84.37/41.57)	............GCLA.SCPRRLGLWVFSPTPVFSKL...........SPVYIKEGDVETTKI..SVDTTTLKVSASGSincselirGLSTdAQSQQATQPAPQRTpqgQSS....GRRS.................
  159-  263 (176.01/95.03)	VAIYAAFIAAVTGALSLHIVQKHGALPLGSRTLFTPV...........NSFGYEDAKIDSQSIFSSSKLTTLNIQLNGP........GTLT.VSLQTTDQPGITRL...QSP....GDDSADLLRMQ..P...GTDI
  328-  447 (140.30/74.20)	VEVWEPFFARLAGESMRQGDESHPTLPL.KRMLW.PArfcfrrrmslqNSLAPEASSIDPLD.FAETWLSTADALTNRP........AGQD.V..QTIDATTKNEE...NSPlidtGDNLESLSRMAqyPdfsGASI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     356.07|      84|     133|     558|     641|       2
---------------------------------------------------------------------------
  452-  510 (82.54/47.66)	PPEGATTHG.IHNLTGHGI.....SPSD.PNILS....PEVPHESKSQKMPEFSP......................................................................kiDIGTGRYDASDDD.
  511-  582 (83.93/48.61)	...DLFGEMNEKDFGSKGITDaDFSFFDePDQENMVDAMVVEQP..QDV..........................................................peeSVTFLPGN...D.DQ..DIGESHQAASTNEI
  583-  708 (94.22/55.66)	PEAMVMNHGSQHEPVSQNVKD.DLTPAD.GDMKQESSRPVSPRPSGQTISPPLSPVEIK..KIlfsglrpnqgrsnqqdpeprsdyqpidfeqrlsswdrkyrnmgkfwfSVGGL.GN...DaTG..DLTSIPTVG.....
  709-  791 (95.39/56.46)	.....MPKLTRHQPLIKHDRG.H.KNDV.GESGEEDSTDSAENSSDEDESGDIVPVEPQpaPV...............................................VLSLLKRKrvpS.DA..DVQSTASPAPSATP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.79|      23|    1084|     280|     305|       9
---------------------------------------------------------------------------
  280-  305 (35.21/32.61)	ASPSLP..SPGLhASGDLVakRRNWKLD
 1366- 1390 (38.58/23.23)	ASPHITelRPAL.ASGYLL..RRKGAFD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.95|      18|     232|     964|     982|      10
---------------------------------------------------------------------------
  964-  982 (29.99/24.68)	TAYCIYPRAlRRVADAFLE
 1198- 1215 (33.95/22.92)	TAYCLRYRN.RGSARAISE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32521 with Med13 domain of Kingdom Fungi
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