<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32519

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMSDRTPAITFPAGPLSPPSPAAGSSAPPESKHLPPFLDPTPQTPTSPPLMSVSDSNNGSNFTSSQAPSNQATIHHNSAHTSSPPSSAPLSTQASQPPTLSATNSFPTPASSVSGHQAHANSSEGTDLKAPQTGTQAILSTMDNGAQLQTADHTRLDHARPPASTSFAATGLHGVAAEGNSDPDAMDVDTEPVSRDDARDLGLDSLQKNFHSAYHLCKSSPPPTGPDPSWDLISLYGLGSIAQSVARIHPVTGEKINRLRKSYEGKLKPMGLAGKNKPIKTDPSKEGSLRYLTLWPEEEWQNQKVFGKQIKTADMDSALLGLQTKAMQLQPGVAPNNDFWEDVLGLEKPIKAPGPGELGKKATPTPIGRPGGPPMMPSGAGATDLGDRARPSRGRKRNYDDNSFVGYGEGYADDDDDTGFYSNGEGIGKKKRKKDHVSKVSTPMSERSGSYGVGMFGIGAR
Length460
PositionHead
OrganismPenicillium oxalicum (strain 114-2 / CGMCC 5302) (Penicillium decumbens)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
Aromaticity0.05
Grand average of hydropathy-0.729
Instability index43.81
Isoelectric point6.50
Molecular weight48412.03
Publications
PubMed=23383313

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364151
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP32519
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     152.52|      37|      37|      19|      55|       1
---------------------------------------------------------------------------
   19-   55 (72.54/29.43)	SPA.........AGSSAPPESKHL......PPFLDPTPQTPTSPPLMSVSDS
   66-  115 (49.87/18.07)	APSnqatihhnsAHTSSPPSSAPLstqasqPPTLSATNSFPT..PASSVSGH
  116-  138 (30.11/ 8.17)	QAH.........ANSSEGTDLK..............APQTGTQAIL......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.32|      22|      29|     356|     383|       2
---------------------------------------------------------------------------
  361-  383 (41.26/19.32)	ATPTPiGRP...GGPPMMPSGAG.ATD
  388-  413 (30.06/ 7.98)	ARPSR.GRKrnyDDNSFVGYGEGyADD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     162.00|      30|      30|     195|     224|       3
---------------------------------------------------------------------------
  156-  186 (42.01/18.83)	DHARPP....ASTSFaATGLHGVAAEGNSDPDAMD
  195-  224 (53.35/25.70)	DDARDL....GLDSL.QKNFHSAYHLCKSSPPPTG
  226-  252 (31.93/12.71)	DPSWDLislyGLGSI.AQSV.ARIH......PVTG
  264-  286 (34.70/14.39)	GKLKPM....GLAGK.NKPI.......KTDPSKEG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.48|      17|      21|     314|     334|       4
---------------------------------------------------------------------------
  314-  334 (18.19/25.24)	MDSALLGLQtKAMQlQPGvaP
  338-  354 (33.29/21.18)	FWEDVLGLE.KPIK.APG..P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.13|      12|      28|     418|     429|       5
---------------------------------------------------------------------------
  418-  429 (23.74/15.33)	GFYSNGE.GIGKK
  448-  460 (19.39/11.20)	GSYGVGMfGIGAR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32519 with Med19 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DDDTGFYSNGEGIGKKKRKKDHVSKVSTPMSERSGSYGVGMF
2) IKAPGPGELGKKATPTPIGRPGGPPMMPSGAGATDLGDRARPSRGRKRNYDDNSFVGYG
3) MSDRTPAITFPAGPLSPPSPAAGSSAPPESKHLPPFLDPTPQTPTSPPLMSVSDSNNGSNFTSSQAPSNQATIHHNSAHTSSPPSSAPLSTQASQPPTLSATNSFPTPASSVSGHQAHANSSEGTDLKAPQTGTQAILSTMDNGAQLQTADHTRLDHARPPASTSFAATGLHGVAAEGNSDPDAMDVDTEPVSRDDARDLG
414
349
1
455
407
201










Molecular Recognition Features






MoRF SequenceStartStop




1) IGKKKRKKDHVSKVST
2) SLRYLTLWP
3) WDLISLY
426
287
229
441
295
235