<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32518

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMPLIMDEGINVDDLFGEAHSLDLGLPPAASLPATKGLAQCLDEMRLLGCRQRIAWSRLGAIAYISADGVRVCVRNLQSGLSDGKWGLSDECSLAPVTEAHNGNQLVHLSWSDAGSDLAVVDCMGRISIYSIFMALNNITGLRQASYDSGDDSNQIVGLMWLNPGRQVQAYQQAAKLNNRWAYSPFRWRPTHPSHPAGKSSLITVTRAGQIRLMYQNINGKWAEVPAELKNTGYSDRLLTHAAMVATQGTILLATYSVCQKLCLYRVEIAWTPNKWDPTVMRSPNKWPVPALRLLHYKIDMPSSIWSINHDSEAQMAQSVPFPNSVYSLTRLEMIPGQVDSPTGPTTTSPWILGVFSKPLHASSEFPLQQGPASVIVRWQLDSTQQSLHPKFDEVVSRKTHTQIKPKIEMRRLEDIHLNKYIVSVDLMEHVTAPALALTHSDGSIAFYETKTMTLFNGLDDASTVNCFAQAGFQFPIDAPGLSIAFSPNSCAAVVLDSGSQPRLRWMEHNFGSSGGLYDEGKFSAAIAALTLAFSRGSGSDSNTDDIMMVVLGQLSLENQPTFLGEVYRALSINCNFTVEPDKIMTHTYIPRALSLQTSLGFRGRNRPRTMPSAMSWTVLQLRHSSLLFATYFQHCNNFPAEQSDSGILHALLGNTRWALSMSQFILNEILDLADDFESVLHDSEAFSQKLKTTTSLPLLISLSSMSRAFMRIICRGLRGVRNGFENVNTAAIDAESRSCWVEICRAIETSPIRVDLYEKFLAGVDSAVKHAYQGSGFGDAERPSPEKELLVNARIPPVLVPAVETLFTQTVPSIRSEINRKEIVMGDYSWLGLDNDPGTATYRKRHDIDILMKVPLRPVTGRQDLAVAPMARRRRCVRCGEISGDAGRPRTNAWTKMMLRLHALKMCPCGGAWVMETPDSVSPEGVSSSGGLGGSGPVNVSKAVEVAGSG
Length950
PositionTail
OrganismPenicillium oxalicum (strain 114-2 / CGMCC 5302) (Penicillium decumbens)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
Aromaticity0.07
Grand average of hydropathy-0.140
Instability index47.67
Isoelectric point6.91
Molecular weight104376.07
Publications
PubMed=23383313

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32518
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     154.61|      52|     135|     717|     786|       1
---------------------------------------------------------------------------
  480-  538 (75.43/39.38)	GLSIAFSPNSCAAVvlDSGSqpRLRWME..HNFGSSG...GLYDegKFSAAI.AALTLAFsRGSG
  719-  776 (79.18/90.26)	GVRNGFENVNTAAI..DAES..RSCWVEicRAIETSPirvDLYE..KFLAGVdSAVKHAY.QGSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.91|      20|     136|      61|      85|       2
---------------------------------------------------------------------------
   61-   85 (30.86/25.32)	IAYISADGVRVCVRNLqsglsDGKW
  202-  221 (37.05/19.35)	ITVTRAGQIRLMYQNI.....NGKW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     211.93|      70|     276|     539|     626|       3
---------------------------------------------------------------------------
  539-  626 (103.48/94.24)	SDSNTDDIMMVVLGQLSLENQPTflGEVYRA.LSINCNFTVePDKIMTH....TYIPRA...lslqtslgfrgRNRPRTmpsaMSWTVLQLRHSSL
  816-  904 (108.45/61.42)	SEINRKEIVMGDYSWLGLDNDPG..TATYRKrHDIDILMKV.PLRPVTGrqdlAVAPMArrrrcvrcgeisgdAGRPRT....NAWTKMMLRLHAL
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     214.07|      64|     196|     127|     192|       4
---------------------------------------------------------------------------
  127-  192 (107.34/68.63)	SIYSiFMALNNITGLRQASYDSGDDSNQIVGLMW..LNPGRQVQAYQQAAKLNNRWAYSPFRwRPTHP
  324-  389 (106.72/59.22)	SVYS.LTRLEMIPGQVDSPTGPTTTSPWILGVFSkpLHASSEFPLQQGPASVIVRWQLDSTQ.QSLHP
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.21|      24|     369|     285|     321|       5
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  260-  283 (45.79/32.32)	KLCLYRVEIA...WTPNKWDPTVMRSP
  292-  318 (38.42/26.51)	RLLHYKIDMPssiWSINHDSEAQMAQS
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32518 with Med16 domain of Kingdom Fungi
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