Description | Mediator of RNA polymerase II transcription subunit 14 |
Sequence | MDNANMDGSSRRPGLHQATNGALSPMGGNEKLGSRATPNGSSHVNGTSRDSEKSDQRTKALQRAPTPFEIPHITQGFFPFGTLVHRAVQNCWNELTELISDLATIQVPADNNTNAPGGSGKSSGNQTAQNMHKKLKILEWGHARRAEFIKLLVLSEWSRHAAEVSRLIDIQGFIRIRHQAYMTAMNSVGMMKQDLVRAQVANPDLKTALEVLAKGKVASLPDFGYKPPKPLSARTALKKLHKINRIISARLILQDQVPHALRNYRVHDGRVTFTVAGEFELDLSVAQEAKTSQFFFVDIRFLFMPSSSIPKGRILDELEVEINRILFNDGLLACFNFLHGLVLTNKVNTLFRQAQDLSRGTWSGLLRIELLHRTLVVQYWTARAGPKSWIEIGIRRGSGDLKTAVPQLHLRWMRDGKQTNSAGVKFDTDSLSMEHILRSVIALHISHVLSLVYTTLKKHLLFANHVLTLGGKLSSSEPSDCFLNVQLTTTRELRVSIEPQTGTPTLSGTPSVVERPEPGPPKPVVEELLGRIARLRCTTAMDEVESSSKGLGLEGVNPRIVGMDVRKLFPPNTLRSAFFTHHTWDRRWITAVTSSMDGDRWWLVQLRPEAGRPTLAHAVSNTIMGIGRRTDYTACAELVYGLTGILAIYANARYLADLPEARFQPVLEKLQLEEDLLVPDLFVDYEPSTLPKPLQIALPHSYLKNGSFIDGAIRLSFQGVDREHNSTILVAHGKLRRRVKSLQLLITQLDPELLVQDQGGGFALRLVVPAGQPAIFGLFERLQRLDCAIYLLQKLIQKGMEPRSISLSQCSFLYGPEKKMLAKFGLEVSGPAITSDTDIGQLMSRSDPIYQLRLKLSFDRPSPHRRIQESLTFALNDRFAETGIDHVLCLMADSFPILCSFDEIVTKSASSETALVYITVRSPTSYQIHYPRQRYRFSLFAHLRRGKTEWVLDDANRDWPSTEPHPVSAVVREQIYNARGDGWQGLGDGARASIHRVGNLLHKLHDCLGTCPPVPEPVKRGANGAARPSIPAKSEIQPQSLKPVPPPAANPTNVSPKKKAAKGNNNVITID |
Length | 1071 |
Position | Tail |
Organism | Penicillium oxalicum (strain 114-2 / CGMCC 5302) (Penicillium decumbens) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium. |
Aromaticity | 0.07 |
Grand average of hydropathy | -0.257 |
Instability index | 45.52 |
Isoelectric point | 9.52 |
Molecular weight | 119009.29 |
Publications | PubMed=23383313 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 ARBA:ARBA00003669 ECO:0000256 RuleBase:RU365082 |
GO - Cellular Component | mediator complex GO:0016592 IEA:UniProtKB-UniRule |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:UniProtKB-UniRule |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP32517 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 44.80| 12| 106| 495| 506| 1 --------------------------------------------------------------------------- 495- 506 (22.39/12.57) VSIEPQTGTPTL 604- 615 (22.41/12.59) VQLRPEAGRPTL --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 85.07| 24| 106| 101| 144| 2 --------------------------------------------------------------------------- 102- 125 (41.98/53.91) LATIQVPADNNTNAPGGSGKSSGN 1041- 1064 (43.09/13.02) LKPVPPPAANPTNVSPKKKAAKGN --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 112.16| 35| 438| 253| 287| 4 --------------------------------------------------------------------------- 253- 287 (61.10/42.21) LQDQVPHA.LRNYRVHDGRVTFTVAG...EFELDLSVAQ 694- 732 (51.06/33.99) LQIALPHSyLKNGSFIDGAIRLSFQGvdrEHNSTILVAH --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 121.32| 42| 437| 385| 489| 5 --------------------------------------------------------------------------- 204- 248 (62.51/18.40) DLKTA.....LEVLAKGKVASlpDFGYK.PPKPLSARTALKK...LHkINRIIS 400- 450 (58.80/100.53) DLKTAvpqlhLRWMRDGKQTN..SAGVKfDTDSLSMEHILRSviaLH.ISHVLS --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) IPAKSEIQPQS 2) NVSPKKKAAK | 1030 1053 | 1040 1062 |
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