<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32517

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMDNANMDGSSRRPGLHQATNGALSPMGGNEKLGSRATPNGSSHVNGTSRDSEKSDQRTKALQRAPTPFEIPHITQGFFPFGTLVHRAVQNCWNELTELISDLATIQVPADNNTNAPGGSGKSSGNQTAQNMHKKLKILEWGHARRAEFIKLLVLSEWSRHAAEVSRLIDIQGFIRIRHQAYMTAMNSVGMMKQDLVRAQVANPDLKTALEVLAKGKVASLPDFGYKPPKPLSARTALKKLHKINRIISARLILQDQVPHALRNYRVHDGRVTFTVAGEFELDLSVAQEAKTSQFFFVDIRFLFMPSSSIPKGRILDELEVEINRILFNDGLLACFNFLHGLVLTNKVNTLFRQAQDLSRGTWSGLLRIELLHRTLVVQYWTARAGPKSWIEIGIRRGSGDLKTAVPQLHLRWMRDGKQTNSAGVKFDTDSLSMEHILRSVIALHISHVLSLVYTTLKKHLLFANHVLTLGGKLSSSEPSDCFLNVQLTTTRELRVSIEPQTGTPTLSGTPSVVERPEPGPPKPVVEELLGRIARLRCTTAMDEVESSSKGLGLEGVNPRIVGMDVRKLFPPNTLRSAFFTHHTWDRRWITAVTSSMDGDRWWLVQLRPEAGRPTLAHAVSNTIMGIGRRTDYTACAELVYGLTGILAIYANARYLADLPEARFQPVLEKLQLEEDLLVPDLFVDYEPSTLPKPLQIALPHSYLKNGSFIDGAIRLSFQGVDREHNSTILVAHGKLRRRVKSLQLLITQLDPELLVQDQGGGFALRLVVPAGQPAIFGLFERLQRLDCAIYLLQKLIQKGMEPRSISLSQCSFLYGPEKKMLAKFGLEVSGPAITSDTDIGQLMSRSDPIYQLRLKLSFDRPSPHRRIQESLTFALNDRFAETGIDHVLCLMADSFPILCSFDEIVTKSASSETALVYITVRSPTSYQIHYPRQRYRFSLFAHLRRGKTEWVLDDANRDWPSTEPHPVSAVVREQIYNARGDGWQGLGDGARASIHRVGNLLHKLHDCLGTCPPVPEPVKRGANGAARPSIPAKSEIQPQSLKPVPPPAANPTNVSPKKKAAKGNNNVITID
Length1071
PositionTail
OrganismPenicillium oxalicum (strain 114-2 / CGMCC 5302) (Penicillium decumbens)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Penicillium.
Aromaticity0.07
Grand average of hydropathy-0.257
Instability index45.52
Isoelectric point9.52
Molecular weight119009.29
Publications
PubMed=23383313

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32517
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.80|      12|     106|     495|     506|       1
---------------------------------------------------------------------------
  495-  506 (22.39/12.57)	VSIEPQTGTPTL
  604-  615 (22.41/12.59)	VQLRPEAGRPTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.07|      24|     106|     101|     144|       2
---------------------------------------------------------------------------
  102-  125 (41.98/53.91)	LATIQVPADNNTNAPGGSGKSSGN
 1041- 1064 (43.09/13.02)	LKPVPPPAANPTNVSPKKKAAKGN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     112.16|      35|     438|     253|     287|       4
---------------------------------------------------------------------------
  253-  287 (61.10/42.21)	LQDQVPHA.LRNYRVHDGRVTFTVAG...EFELDLSVAQ
  694-  732 (51.06/33.99)	LQIALPHSyLKNGSFIDGAIRLSFQGvdrEHNSTILVAH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     121.32|      42|     437|     385|     489|       5
---------------------------------------------------------------------------
  204-  248 (62.51/18.40)	DLKTA.....LEVLAKGKVASlpDFGYK.PPKPLSARTALKK...LHkINRIIS
  400-  450 (58.80/100.53)	DLKTAvpqlhLRWMRDGKQTN..SAGVKfDTDSLSMEHILRSviaLH.ISHVLS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32517 with Med14 domain of Kingdom Fungi
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