<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32498

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMVHSDLPLEWVKLCRLFISKELPNNASDDTGAALSNSVLLLLQSYPGDPMLQEYLKRAIEENLISVSTFISTFLQAARSSELQNPATLDMLCRVALDSHYSSGVPPIGSVVPYSESSITVLGTVQDALALLRTAHNLPMSHYHQLTTSASELVILLLSCVTDMSQVSTAQAMVVYQDANEMLQTLRLSSDVRQVLETFVMSLHLLMGDDAKAAREAQMMHAIQMALGKDILGPNSDTDIVTCSLMFHYFLAYRADEFGSGHGDHVVAILLRVLRSTSWTPQVFYTQLLLSAVTCLAQASSSGTEKRAALLWRAFVTARLPRLLAQFQSTVRHDSTEEADWRIALQFALTSLFQRADLLAHCDNVNFNMDPLDSMNEGMQSSRLFARDFLRQLVTEGLLDSSFANNLDQGLANDNSPQVQTDAQELGMNLEHYIDNRVSTDPSQYDSSAFVEKVCGDPSSHAPFADTVHRRFCSLTSSLEAEGLSNLCKLLYVYPIAMDLVSLHCKVSDMVARALMFLEEYDCESVGDPQTAVSHLGDVVLFLQSTIAQFQISSREFKLRERTLRLEFLITPSIQQIDQLAREDSNAFYSWFKALFDSNSEGIEDTILRTTRPKTLLRLAPLLFLHAIAFHIQNQMDKDVLNNGVSYFLGPLLHWTLVGIVKALITEIQRIGSQARAHLEVLQILLTSQSCPRPVLRLCGPSIMRLLVIPLVRDVAKTAAVNWPRRSSATNSAGVQAHMGTGNIVPWTDQPRQAIREALAMARSGKAPALDVDRCLLVLPSVKFLHLLWSELLAASCEGAIEACRRIATFVLTTPRASNGPPLMPTFLHVVLPSLITSVDQQSPANQTMSMELMVSVISYALTASLHTEWALHTVCGDDRPVLGQSTAGMAKRLSSELRRRKNSPTAGVISQRLSSSSSFVANFPMFMAET
Length930
PositionTail
OrganismGloeophyllum trabeum (strain ATCC 11539 / FP-39264 / Madison 617) (Brown rot fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Gloeophyllales> Gloeophyllaceae> Gloeophyllum.
Aromaticity0.07
Grand average of hydropathy0.073
Instability index50.78
Isoelectric point5.76
Molecular weight102754.81
Publications
PubMed=22745431

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32498
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     275.41|      91|     135|     417|     551|       1
---------------------------------------------------------------------------
  313-  415 (139.68/130.61)	AFVTARL..PRLLAQFQSTVrHdsteeadwRialQF.ALTSLFQRADLLAHCDNVNFNMDPLDSMNEGMQSSRLFARD..FLRQLVTEGLLDSSFA.NNL.DQGLANDNS
  448-  545 (135.73/112.21)	AFVEKVCgdPSSHAPFADTV.H........R...RFcSLTSSLEAEGLSNLCKLLYVYPIAMDLVSLHCKVSDMVARAlmFLEEYDCESVGDPQTAvSHLgDVVLFLQST
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.16|      13|     133|     155|     167|       4
---------------------------------------------------------------------------
  155-  167 (24.62/13.52)	LLLSCVTDMSQVS
  287-  299 (21.54/10.98)	LLLSAVTCLAQAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      92.63|      35|     135|     563|     603|       5
---------------------------------------------------------------------------
  569-  582 (11.52/10.08)	............................ITPSIQQIDQLARE
  583-  603 (27.54/12.02)	DSNAFYSWFKALFDSNSEGIE.....................
  715-  756 (53.58/34.15)	AKTAAVNWPRRSSATNSAGVQahmgtgnIVPWTDQPRQAIRE
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32498 with Med5 domain of Kingdom Fungi
Unable to open file!