<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32492

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMATTNGVNGVNGHKASSGTVDVSGPSTSNEFHETSLEELERELPVVYDGQVPLGDLLSRVTQAIYAELLEMAETLPNMSKEARARTIADWVVKTKKQVVKLYAVVKWSRDADTVQKAMNITAFLMNQNQQFLDAIDSLARARDNLDPARLRNHDLLTSLDVLTTGSYRRLPSVIKKLIVQPPPLSDDEVNKIVADVEDRIRYRLRMTEIIPIEMSKYTIERGRVRFAAPRLFETSLCLRGAQKDDGWFFVDVEFLFNVGGDETGMQEFPRVPTGVMKRHITEGVDAQLAMYVPITPPPEGQVPPVELPPRPQLPEGTMDAPLVRVYNFLQMMSLSYQLEIMAYQAQRMCNLGWAEYLQLGMSRDRKTFSVSYWIRKAPLPNSRMKIPPLGGTLTVSIARVRAIPKVGGGPARSAKDRILAELQQRAKLNTARPSDEVETLRFEAKWEPVKNALGVPVALEDLAFTDGELGVDSDNLDFEALLRKVLYKHAKAILRAFQIQLQRKPVFAHPGEVSLVESDGNLALRIHLCADEIVLVSLDLRTGRITLRDTGDLAAAGRGPRFAHITQRLNDAPQGITDAVPFLRILTITDLAEQKANYLGLQTYRQRPFKAEELGKLGPAIRGLLYVQLAKFPNHYLVLVIMDDELRYALISVRIQTDVYQTMIMEDIGWLDVKRIHGDDLLVTVDDHLNSSRGQKHKVKSADESQPAIDAPRADMGRTVNSLNLETQVLRELYSYCCARVAYMKVEQQLKLRGIPYIHVNPSEASRVTPELLHIQSSLARSVPGLCVQSSDILSGAPAAEAAMPNIRVIPLNWWSDKKAQVVTCVKLKYVQQPMGKRAGTSAVIRPSKRIIYDTEEAVVSFLSEDVDKCVDEFLEEWARVSKMVVIAREVGQMSKEKKWPDIRMLSFDLQTVEFAYAADYTVSITCTDQLSPTGGTYELRFSRASYSTLEDRFNPHEDSEPFLRGLLRRGRLAESLHTLVSLLRHTLPIVVQLAEIQKEAADQSQFLDTFPKAVGWYRLLYGDFRQVSTHALDFRLFEGQQIAILDASHSLYSRDTSGNLSLPGPDPGSPSKRQTVGVSSLTGKPIQRNDAVHELMVLQPIPTFQDLVQETVKEVGSATKVNAHITAVDVGIICDIPLARSAIMTLHKKVLRKLVGGRTS
Length1161
PositionTail
OrganismGloeophyllum trabeum (strain ATCC 11539 / FP-39264 / Madison 617) (Brown rot fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Gloeophyllales> Gloeophyllaceae> Gloeophyllum.
Aromaticity0.07
Grand average of hydropathy-0.208
Instability index40.44
Isoelectric point7.33
Molecular weight129807.74
Publications
PubMed=22745431

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP32492
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.90|      31|     203|     734|     793|       2
---------------------------------------------------------------------------
  498-  529 (51.60/21.64)	QIQLQRKPvFAH..PGEVS.....LVESDGNLALRIH.LC
  749-  787 (40.30/45.08)	QLKLRGIP.YIHvnPSEASrvtpeLLHIQSSLARSVPgLC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     377.01|     156|     805|      45|     233|       3
---------------------------------------------------------------------------
   52-  229 (222.64/223.82)	PLGDLLSrVTqaiYAELlemaETLPN....MSKEARARTIADWVVKTK.......KQVVKLYAVVKWsrdaDTVQKAMNITAFLmnQNQQFLDAidSLARARDNLD.PARLRNHDLLTSLDVLTTGSYRRLPSVIKKLIVQPPPLSDDEVNKIVADVedriryRLRMTEIIPIEMSKYTIERGRVRFAAP
  388-  483 (87.33/49.27)	PLGGTLT.VS...IARV....RAIPKvgggPARSAKDRILAELQQRAKlntarpsDEVETLRFEAKW....EPVKNALGVPVAL..EDLAFTDG..ELGVDSDNLDfEALLR..............................................................................
  967- 1030 (66.97/33.77)	.............................................................................................................LLRRGRLAESLHTLVSLLRHTLPIVVQL..........AEIQKEAAD.......QSQFLDTFPKAVGWYRLLYGDFRQVST
 1082- 1116 ( 0.06/11.48)	..........................................................................................................................LTGKPIQRNDAVHELMVLQPIPTFQDLVQETVKEV.................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     190.37|      63|     251|     314|     381|       4
---------------------------------------------------------------------------
  314-  358 (72.69/39.23)	......................................................................................................................................................................................................................PEGTMDA.P....LVRVYNFLQMMSLSYQLEIMAYQAQRMCNLGWAEYLQ
  359-  381 ( 4.98/ 6.55)	LGmsrdrKTFSVSYWIRKAPLPN.................................................................................................................................................................................................................................................
  573-  606 (40.56/18.26)	.......................srmkipplggtltvsiarvraipkvgggparsakdrilaelqqraklntarpsdevetlrfeakwepvknalgvpvaledlaftdgelgvdsdnldfeallrkvlykhakailrafqiqlqrkpvfahpgevslvesdgnlalrihlcadeivlvsldlrtgritlrdtgdlaaagrgprfahitqrlndaPQGITDAvP..........FLRI......LTITDLAEQKANYLGLQTYRQ
  617-  670 (72.15/40.18)	LG.....PAIRGLLYVQLAKFPN........................................................................................................................................................................................................hylvLVIMDDELRYALISVRIQTDVYQTMIMEDIGW.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.02|      23|      39|     796|     823|       7
---------------------------------------------------------------------------
  796-  823 (32.95/37.54)	GAPAAEAAM..PNIRVIplnwwSDKKAQVV
  836-  860 (34.07/21.55)	GKRAGTSAVirPSKRII.....YDTEEAVV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32492 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MATTNGVNGVNGHKASSGTVDVSGPSTSNEFHETS
1
35










Molecular Recognition Features






MoRF SequenceStartStop




NANANA