<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32486

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMATDQSTYNVDDLLSSFYRIEKLEKVNFHQYVPKKQEDQWSIQMELLLRKQNPRNLVALLSRELWCFSINDQEVPTPPRLSGDDNNEVLIPDKKGQFAADYSKPNLPPHYALFLKALRRMIYINITANSFNKLIPYGNACIFLEDSKSCHILLIEPHLFDIGVLATTITTKSPGLIPLTVDRIDDNFLRHHALYLAPSGIRMYLPSGNRQRFLARPPKNAEVLLMTLYVSHGIRLIEKKDLQWVKLIPHLGHLNGHTPNIASYMDSPTDSRTIVWPLDLCFAQKASDVHYDSKDSPCYHDLNDAFDIIEDFVQLKQTSAYRTPKSSNGALGSGLAGNSLSSGGGYTEQFQHYYRSQVGSAPSTSYLLSKENSDPKALSRDISPAYLSFDKPLSGSGENFGSGAFSTTPNLNESELFNDKKSLINDSEVSPVKSEVGSNLKHMLREGEAGTASTMTSPNQVISPSHSTGAITDSPGNEELFGDEDDDEDLFGDSNNYSGGENKSPHGTYIHKSKSDEITDDMFGMSEDEDQDRRSNSNENMYFFKDGRTSAMEPSLKKPSIKRKYLDIPIEEMTLSHTPLYTDPGAPLPIETPREKRKSVFAPLNFNPIIESNVDNKYKNGGKFSISPSHNDEALIFDISTADSSSSEEESDSSDDLEGLNIRQDMRSTDLTEQDAPFGGSISNFQPAVPQAFVRSELMSASLPRANDIMKDGANGIWKISHPDMSQQDPLLSTVNDNMVAADGSLAKMGTTTEQYPNSNKLQKDEPPSGLSENETSIPEPAAADTSLMPESSSSLPFLLRHMPLSSIPDVFFCSKATASITKKNQDILGLLAEQIVFDCGMFDSFGGQEVAYSALKDCENGLIFNTLQELFSEFTRIKGDDIISKIYRMSEPAIHVKRHHEVIKMNADSQVFSQYLDVKPAKGIKNFRFLMLTTSFFHECSSFVSTLSQTYINFEFGFCELLKLTNEDAQGLNFLKDFDESKLLLLAAQIVSYCSTNKNAGNNVPVMIILPIDSDGLEEIVTKTTKFEIIRNEVLSKIPNAQLFLKLILMDFVRNPLIPVDAYSNLCLSIYNILPPKTLKFTSIARTPPKKITFRTMQQSNSSSAIHYDAFIHLAYARSIDKEWVFAAFSDSTGNENIIKTLFVGKSRTKFDEACNEIWATALRLAGRKYGKICLILTRLNGVLPDDELMNWRRLSGRAVHLAVVCVDDNTKISFVDKDPSYPTFKLLLHHIGMEKTLHNSNFDDYEIRNIYEDVHGVIFRNSFPLSNSQHRCAIKSGALVRYKNCSGEQILDKFEVNLLNCPHSDSTKLLETILEEFRNLSALNSWFGISNGDVTHIPWHVLAVKKMMKNLVHTRVKILE
Length1361
PositionKinase
OrganismZygosaccharomyces bailii (strain CLIB 213 / ATCC 58445 / CBS 680 / CCRC 21525 / NBRC 1098 / NCYC 1416 / NRRL Y-2227)
KingdomFungi
Lineage
Aromaticity0.09
Grand average of hydropathy-0.378
Instability index47.45
Isoelectric point5.52
Molecular weight152445.53
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32486
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     515.72|     157|     298|     766|     931|       1
---------------------------------------------------------------------------
   11-   57 (31.04/ 8.84)	.............................................................................................................................DDLLSSFYRI.EKLEKVNFHQYVPKKQEDQWSIQMELLLRK....QNPRNLV
   77-  234 (221.29/122.60)	PPrlSGDDNNEVLIPDKKgqfAADYSkpnLPPHYALFLKALRRMIYINITANSFnkLIPYGNACIfLEDSKSCHILLIEPHLFDIGVLA.........TTITTKSPGLIPLTVDRIDDNFLRHHALYLAPSGIRMYLPSGNRQRFLARPPKNAEVLLMTLYV....SHGIR......
  766-  931 (263.38/162.01)	PP..SGLSENETSIPEPA...AADTS...LMPESSSSLPFLLRHMPLSSIPDVF..FCSKATASI.TKKNQDILGLLAEQIVFDCGMFDsfggqevaySALKDCENGLIFNTLQELFSEFTRIKGDDIISKIYRMSEPAIHVKRHHEVIKMNADSQVFSQYLDVKPAKGIKNFRFLM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     303.94|      80|     352|     253|     341|       2
---------------------------------------------------------------------------
  256-  338 (135.30/92.63)	HTPNIA.SYMDSPTDSRTIV.WPLdlcFAQKASDVHYDS...KDSPC....YHDLNDAFD.IIED...FVQLKQTSAYR...T..PKSSNGALGSGLAGNS
  451-  525 (87.54/49.93)	.....A.STMTSPNQ...VI.SP.....SHSTGAIT.......DSPGneelFGDEDDDED.LFGDsnnYSGGENKSPHG...TyiHKSKSDEITDDMFGMS
  556-  634 (81.09/42.80)	KKPSIKrKYLDIPIEEMTLShTPL...YTDPGAPLPIETpreKRKSV....FAPLN..FNpIIES...NVDNKYKNGGKfsiS..PSHNDEAL........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     119.40|      36|     303|     654|     689|       3
---------------------------------------------------------------------------
  654-  689 (63.09/42.68)	DDLEGLNIRQDMRSTD...LTEQDAPFGGSISNFQPAVP
  967- 1005 (56.31/37.25)	EDAQGLNFLKDFDESKlllLAAQIVSYCSTNKNAGNNVP
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32486 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ADGSLAKMGTTTEQYPNSNKLQKDEPPSGLSENETSIPEPAAADTS
2) LIFDISTADSSSSEEESDSSDDLEGLNIRQDMRSTDLTEQDAPFGGSISNFQ
3) SELFNDKKSLINDSEVSPVKSEVGSNLKHMLREGEAGTASTMTSPNQVISPSHSTGAITDSPGNEELFGDEDDDEDLFGDSNNYSGGENKSPHGTYIHKSKSDEITDDMFGMSEDEDQDRRSNSNENMYFFKDGRT
741
634
413
786
685
548










Molecular Recognition Features






MoRF SequenceStartStop




1) ALIFDIS
2) IKRKYLDIPIEEMTLSHTP
633
560
639
578