<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32462

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMSTTTNSFPISLRSWPSSKNSDATSLSTLFQRINGERGGIQGLTEESLRQEIAAEAETKMDEDDTSENEDEDEEQPDKLRELMEAKGEMLGLLESAYVSSAVTLDFLSLLQSKDNPVQAASTMSQDIKLAVPTGTLGADKLNGPQINRAQMLDNKRIAKGWKVQNVDKTIDSILNAATRFKNEVESETKYWEEVVSVSEKGWSLCRLPSERHTLGVRFGFLEASMTFRNQSLAALRRNADGSIFLDQGFTGSEPKILRVRVQVGEIYTGTSQVPKATGEDASVESLIQQARNTIFFTELWQELNRESRNLGGADVKATEDSLILPLNSEKRIILDLVNIADLEAPAPQEDDHIAQGLCLSLQLLLSYAHRQNHRRRTLPPPPISGQKRTNPPYNLLRPIITRLGHQRTVNTLTTLLRDLTSLLTSASLEAKFSITHNQPQLPSNINLANSERTILSLTERLESVATFSPNPSTTINIILQTQQLSTGVSQFLLTVNPDSPLTTIAPHPNWMVYNIEAITEYVFYATTSVLSASIAKTLYPLEGEETPKSSRGSEGWHLTIQPNVLRKNFEGGTAKQMIVDVSDHPKKGIRLRVGWDWMRLDPFGTSTGKALDQERKSKGEGVYEWRVKRKEPSEGGLEEVVRSLDDVVEQAGKWVYV
Length657
PositionHead
OrganismGlarea lozoyensis (strain ATCC 20868 / MF5171)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Helotiales> Helotiaceae> Glarea.
Aromaticity0.06
Grand average of hydropathy-0.464
Instability index52.48
Isoelectric point5.40
Molecular weight73129.47
Publications
PubMed=23688303

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364140
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP32462
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.14|      18|      38|     545|     562|       1
---------------------------------------------------------------------------
  545-  562 (34.32/22.36)	ETPKSS.RGSEGWH.LTIQP
  583-  602 (26.82/15.86)	DHPKKGiRLRVGWDwMRLDP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.25|      21|      40|     269|     291|       2
---------------------------------------------------------------------------
  269-  291 (25.76/23.15)	GTSQVpKATgEDASVESLIQQAR
  311-  331 (35.49/20.20)	GGADV.KAT.EDSLILPLNSEKR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.35|      12|      40|     466|     477|       3
---------------------------------------------------------------------------
  466-  477 (22.60/13.08)	TFSPNPSTTI.NI
  503-  515 (20.76/11.45)	TIAPHPNWMVyNI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.65|      13|      16|      92|     104|       5
---------------------------------------------------------------------------
   92-  104 (20.72/12.71)	LLES..AYVSSAVTL
  109-  123 (17.93/10.07)	LLQSkdNPVQAASTM
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32462 with Med17 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) NGERGGIQGLTEESLRQEIAAEAETKMDEDDTSENEDEDEEQPDKLRELMEA
34
85










Molecular Recognition Features






MoRF SequenceStartStop




1) EGVYEWRVKRKE
2) VGWDWM
620
593
631
598