<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32461

Description Transcription mediator subunit Med12
SequenceMTSRPILGQRQPPQRSLSTTNTIPRPPPHRTLSQQFPSSSPTRRGTDGFVDLTFDGTDAAQGRYGTIPRMGGSRLKLEISDTNNREFIESPKTASAVTPTWRPNVTPHARSQLHFEIPNVSNLNLSPRAAQEGGHGESATKPMPLPVRPGQYAPSSSRKVRPVAASTAKKDVRPKPYTLEVPAAAPRVPNNGHVDFFPWTGNHPEDQFSAEIIRGGYYEKNPMTHNEAASARAALFPALKHKTGLQTLSSIFTSILAARRAHGQITTTSTFKPPPRVTVTDTKREMWLKDLANPTISLRRLSRSIPHGIRGKVLLDQSLTKNIPIERAVWLAKCVGANELRGFRRKGVSGTFAMGGEAKWIRDFTVCVEQFVESVIGGCGEPEFRERVNYAIRLAAHFHAEHLLDREHYMEWLVSSLENSPQAKLPLWILITQIYWKDLMQYRKYGRRLATALMKHFTEAAGNPDQDIVAPLTERLRQLLKSLMKSYPDSFISPSAWAKHREVIQSDFSSDVNYPRTSFENIDRRNRRLSLPGKDKESTPQQRIIQLLDQTLSGLPSDDLPKRCWKIDQDKLLLIRAVIAWSTSSHRPGCTKTYVAARICRFWAKNGFDLTSAILDFADSEQCSTGRDKPAFYHLISELARSEHFSTAKYIQWLISRGGLQNVTDVAPDGPCATRLLAELPTHNLSEGILNLHSTLLDRVEISVDEEEDNMRNCMAFMNNNLPAMRSAQDSDMDLDEAVVVGDPVTLISKLSRSSKSEIGLWLRHKVMLHMRQTAKIQPEAWEAGPAKRVEQPTITAADFDKVRYYLELIEDYSMLADVLKITVSSNDPEVLASCADTINLHIDTLAAIGAVQSLFEILSTRLRILANGHDSLPRTLLASLADLASRIPSQRVAAQQWAQELALYDRRTAADACSPVSDHIAITQTSEVDFFEEMEKILASGNSMDQPTLGRLFERISHHLESTWEKSPREQKNCGLLLTRLRPFDAEHFDTLIAAWLKKFLALPGRPSMMMALGPLVSFGCLSLTDISKMCKTVDIPGNALSNSRISQELVQLLLSTPTSTIQAMGAEDSYRLRVRQANTYKDSPEQVVSSIQYGVEQARSQKATPGSPILPDVFAIIRDHNSFEVLQRFALLQPDMVIQSLVTPLLKTENSAAARVITSIVNQLLFGNGDSNGDDSTEAILKVANDLTLPFCQIKLESMFSGEDSTMAGVDDAKTSRLQAFDSAIEAAVNSGKTAWASIVPLLEVSVAQHLRRRSELQFLALIPSPKTISTYEPSKLNARLEHANNLLRIVDSTAYSVAETENKTSNNTSIAQDILIVLNGVRVLISTTQNIPAKDDVIRKWLPLLLRFITLHTSEFESTKPGHENRAKVILSLSAILLELQALDTNTSPAHDLSEQINDLAIYLVDGLPEDFRQQAVRSLYETMHNAQMYYLFSFQPSPSDGLVLSQKDTPPTTAPGENNTDPRPFMGANRDKLTPFVLRRWEMLEEPTPNVGENDTSLNLTLFGARRG
Length1512
PositionKinase
OrganismGlarea lozoyensis (strain ATCC 20868 / MF5171)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Helotiales> Helotiaceae> Glarea.
Aromaticity0.07
Grand average of hydropathy-0.333
Instability index47.61
Isoelectric point7.43
Molecular weight168414.66
Publications
PubMed=23688303

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32461
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     175.13|      54|     214|     160|     243|       1
---------------------------------------------------------------------------
   97-  156 (85.84/36.24)	VTP....TWRPNVTPHARSqLHF.....EIPNVSNLNLSPraaQEGGHGESATKPMplPVRPGQYAPSS
  160-  222 (89.29/84.41)	VRPvaasTAKKDVRPKPYT.LEVpaaapRVPNNGHVDFFP...WTGNHPEDQFSAE..IIRGGYYEKNP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.58|      30|     214|    1149|    1202|       2
---------------------------------------------------------------------------
 1173- 1202 (52.36/63.84)	SNGDDSTEAILKVA....NDLTLPFCQIKLESMF
 1391- 1424 (46.22/16.81)	SPAHDLSEQINDLAiylvDGLPEDFRQQAVRSLY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.23|      29|     213|     860|     892|       3
---------------------------------------------------------------------------
  861-  890 (45.19/30.56)	TRLRILANGH.DSLPRTLLASLADLASRiPS
  980- 1009 (49.04/19.50)	TRLRPFDAEHfDTLIAAWLKKFLALPGR.PS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     474.31|     157|     240|     249|     419|       5
---------------------------------------------------------------------------
  249-  419 (235.54/193.21)	SSIFTSILAARRAHGQITTTSTFKpPPRVT...VTDTKREMWLKDLANPTISLRRLSRSIPHGIRGkvLLDQSLTKNI.PIE.rAVWLAKCVGANELRGfRRKGVSGTFAMGGEAK.WIR...DFTVCVEQFVESviGGCG....EPEFRERVNyaiRLAahfHAEHlLDREHYMEWLVS..SLEN
  490-  662 (238.77/152.17)	SFISPSAWAKHREVIQSDFSSDVN.YPRTSfenIDRRNRRLSLPGKDKESTPQQRIIQLLDQTLSG..LPSDDLPKRCwKIDqdKLLLIRAVIAWSTSS.HRPGCTKTYVAARICRfWAKngfDLTSAILDFADS..EQCStgrdKPAFYHLIS...ELA...RSEH.FSTAKYIQWLISrgGLQN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      33.94|      10|      18|    1139|    1148|       6
---------------------------------------------------------------------------
 1139- 1148 (17.18/11.62)	VIQSLVTPLL
 1158- 1167 (16.77/11.14)	VITSIVNQLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.99|      21|    1439|       6|      26|      17
---------------------------------------------------------------------------
    6-   26 (39.83/23.75)	ILGQRQ.PPQRSLSTTNTIPRP
 1447- 1468 (36.16/20.79)	VLSQKDtPPTTAPGENNTDPRP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32461 with Med12 domain of Kingdom Fungi
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