Description | Mediator of RNA polymerase II transcription subunit 19 |
Sequence | MPSDHPQTPESPSHAVSGVTDLYRKTSTSPQFTNSLPTPAHSINGSMSALGADSMVSGFSQDDASNKRKRDPEDSGDRDQKKVHLEEARLTIEQLHLDVGEKYLLCRTPHPRQSPHLSQDLFAMYSLNNVAQSVARTNPDGTKNPLRKTYKKYIKTLGLSGAFDVGKKELDAPDTLSALIMTPDDQWEAQNTTSRPMGKGFSDEVRSSLGSAFKMAKGRIPKDRFDSSVLGEIVARPVDMSKLASNGIKPHPPQNPAVARTAKGEVPRPKRNVKKRSYGDASFEGYGEGYIDDETQDTGYSTGEGDDRSGRKRPKKNGPPHNYQGPLRQNSYGPGMVGV |
Length | 339 |
Position | Head |
Organism | Glarea lozoyensis (strain ATCC 20868 / MF5171) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Helotiales> Helotiaceae> Glarea. |
Aromaticity | 0.06 |
Grand average of hydropathy | -0.941 |
Instability index | 40.99 |
Isoelectric point | 9.13 |
Molecular weight | 37068.82 |
Publications | PubMed=23688303 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364151 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP32456 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 145.40| 44| 140| 17| 62| 1 --------------------------------------------------------------------------- 17- 62 (71.80/41.54) SGVTDLYRKTSTSPQFTNSL.PTPAHSINGSMSAlgADSMVSGFSQD 160- 204 (73.60/37.55) SGAFDVGKKELDAPDTLSALiMTPDDQWEAQNTT..SRPMGKGFSDE --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) PLRKTYKKYIKTLGL 2) RKRPKKNG 3) YQGPLR | 145 311 323 | 159 318 328 |
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