<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32455

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMDEEMMDDLFGDGGGLSIPSRPPSKELYQRLDDLRRGGCCQGIAWSNWGCIATIASSGAILELRNLRCHPEDANLDGGPLKHLCWSTSGSELAVIDTAGRVNILSLFSSLNKPTLHRHCQMDPIDELCGIVGCHWLTPAPYQANRPAQLNGPAVKEGSSYKYETSAAPVYGPFHPVLGKSALVCVTTNGTLRIIYPQVNGKYAEVHTELESIVSSDDLITHAAIGSDRNQTLLIAFATTSKQLRVVRAVIDWGQQKPTERGAQPVPQQPLNPSIRTRHVAVTSWLHDSPSDNINSLNTESSMMQLSHLEFLPSSLEPGGRLTPPTIVAVRSHLPPSMAHYNQEVHTVVDRWEIREKMQTVHPAFEQLSSRRNSIGSPPQAMSFLKKLDSFTVNKILLAIQPINLGRVLFFMYSDSSVEYRDRTTMAETFTDNDLDRVWHLSQIGFTYPEDEPCLQVALSPSYCSMVQIRNDGKVKWKQLDYAIGDIGSDNSDPQYAAVVAALALSCSSAVMRNVAYDDLLPIAAKYSNTNLTFDWLVELSSVLKVPLDYSEEQHADLLIRNSTIQLFHSIQSSLGFRGEFEPRSFPGKLSWLVLQLRNIVVLVTMAANLGVRGDGPNPNEKTSPLDDPEVINALAGSVRWTLDLMAWLTDTLLTLSSTLPPGMDLTNVKGFSLPELHAHLVKTNTVALHLLLSSSTRGFLTAICRRLSHLDWIARRAITPSAGNTGSGTPNTQGSNPDKQPSPALRNAYLHIATITTNTILRIKTIDTLLSALTTSIKDVYSTILPKSQTSDKSTDKANEKARNAYEIKIAFGGPFPEAFKPIIVELFRADGLLAAVREDIEPAKLFFADFSLLEVNEDKASLAKRKASGMTMDCFRKTWLPNPKKGMDLVEGKQVPRWRRCARCAAVMVDVLTERRALQWLIMQQRRCFCSGYWNTVAAGETVA
Length945
PositionTail
OrganismGlarea lozoyensis (strain ATCC 20868 / MF5171)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Helotiales> Helotiaceae> Glarea.
Aromaticity0.07
Grand average of hydropathy-0.189
Instability index45.49
Isoelectric point6.65
Molecular weight104387.02
Publications
PubMed=23688303

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32455
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     139.79|      46|      55|     706|     753|       1
---------------------------------------------------------------------------
  706-  753 (76.63/46.10)	RLSHLDWIArRAITPSAGNTGSG.TPNTQGSN..PDKQPSPAlRNAY.LHIA
  762-  811 (63.16/30.98)	RIKTIDTLL.SALTTSIKDVYSTiLPKSQTSDksTDKANEKA.RNAYeIKIA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     114.89|      40|     224|     585|     674|       3
---------------------------------------------------------------------------
  260-  337 (53.44/12.83)	RGAQPVPQQ...PL.NP........SIRtRHVAVTSWLHDspsdninslntessmmqlshleflpsslepggrltppTIVAVRSHLPPSM
  612-  663 (61.44/106.51)	RGDGPNPNEktsPLdDPevinalagSVR.WTLDLMAWLTD.....................................TLLTLSSTLPPGM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.02|      10|      38|      37|      46|       6
---------------------------------------------------------------------------
   37-   46 (22.73/17.28)	GGCCQGIAWS
   77-   86 (22.30/16.79)	GGPLKHLCWS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.19|      16|     353|      17|      32|       7
---------------------------------------------------------------------------
   17-   32 (29.46/18.42)	SIPSRPPSKELYQRLD
  373-  388 (28.73/17.77)	SIGSPPQAMSFLKKLD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.50|      20|     119|     552|     578|      12
---------------------------------------------------------------------------
  552-  573 (26.59/39.00)	EQHADlLIRNSTIQLfHSIQSS
  675-  694 (33.92/19.47)	ELHAH.LVKTNTVAL.HLLLSS
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32455 with Med16 domain of Kingdom Fungi
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