<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32450

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAALTNGTNHDRDAAAMNGVNGDAAAGAPSEAATSSTRMNNLPDRIQHVTDNYVPLGFLLQRLAQKTHNNLQDVIRELARKPVAGMEGSAAAQRPTDDGSIDNIEKKKTLLNFARSEHANWVKALVISEWSKKADQISKLIDLENHMFEEELSKYEQAVFTMLNMKRNLGGARLTSPDLKTALHVLSRGNAPWMPDLGFIAPPPLSSTDQAKRLDDISTLLALRLNLEDYDSIPYQFRDNYTIESGRVTFRVPNEFEVDLTLASDDFTQQLWFLDLRFLFSPAPDDMTPALRGFLEHQLNIVLEQEGLPGCYRLLHEFALTHKINELRRQMNELARGRWIETIRIEKLNRAICVQYWTTQGLNNSRHWFIIGAHSGHDAATADLPDEQITSRLNLRWFRDGKEVKDAAGSGDNSVRNMLVSAVADNTANVVSAEKILQTMAALHVEHILSGIHAKLAAKPMFAQRRAAMRLRICRTDASRSFLDVQLSSPTDRVCVRIDPVTGLFSLSPQHTRAAVTTENRLNAASMNPAAAAAAVLASSSAPDGKDPIDEGLALLEGARCAAAHEELSRRAKTYGWTTVRHGGPSGPNQNSPPLPLARMDDVRQVINMRDHNQVLWLKRQDWAPQWHILASLSLSGDRWWLVKLSEQPPPPSQQQQQQQSQAQRNEFNLRSDGARILMHMLLPMGSKPTDFNKAFFADLTIYATGIMAQYTDTQELTRRKKMAEVARVENPYLPLRAKLPALSILLSDLLSTNSTHSPSSSPSLGDADSTIPISARLPGLSADNSDGMTTTAAPTVRRWWASDHVQLLFRGIESSDALSVASPETAKQRRLVVLAEARLFVQDRAKFRLLGTSSRVVDDDVAFNARTGQFRLYLRAEVGHTVIDTLVGRLRAIERLVGFLDAIRRESRVVHSQSVSLNRLVFSYSVGPGAKPQELTTEAAVASARAATSNGRWRVTIDLSSSKQVRLQLEDKCPHLRVADYLGRIANNSSTLATLPFFLTATLSLHRALDRMEDAWEPIVMRNIGMLSILPRALDWIVVRIMLMTSGAGAAGAGGAGAAPPPSARNVRQLALDIRLRTRRNEAMWQIRRVEEPSRSSSNNSSSSAPEDDLSKVMRRIFEGSGPGWQGLSTAAVASPYPGNSVEDSESASASASISSSTPRGATGIEDCLLQIDEAIRGLQVTSMPPNLQTTQMIQIQQQRRAHAHAQAQAQAQAQAQAQAQSYQAQTARMG
Length1232
PositionTail
OrganismOphiostoma piceae (strain UAMH 11346) (Sap stain fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Ophiostomatales> Ophiostomataceae> Ophiostoma.
Aromaticity0.06
Grand average of hydropathy-0.344
Instability index49.34
Isoelectric point8.91
Molecular weight135795.19
Publications
PubMed=23725015

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP32450
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     944.54|     316|     360|     377|     732|       1
---------------------------------------------------------------------------
  390-  732 (475.20/425.71)	TSRLNLRWFRDGKEVKDAAGSGDN....SVRnmLVSAVADNTANV..VSAEKILQTMAALHVEHILSGIHAKLA...AKPMFA.QRRAAM..RLRICRTDASRsFldvQLSSPTDRVC...VRIDPVTGLFSLspqHTRAAV......TTENRLNAASmNPAAAAAAVLASSSAPDGKDPIDEGLALLEGARCAAAHEELSRRAKTygwTTVRHGGPSGPNQnsPPLPLARMDDVRqvINMRDHNQVL....WLKRqdWAPQWHILASL......SLSGDRwWLVKLSEQPPPPSQQQQQQQSQAQRnefNLRSDGARIlmhMLLPMGSKPTDFNKAFFADlTIYATGIMAQYTDTQELTRRKK.MAEVARVENP
  747- 1094 (469.34/315.74)	LSDLLSTNSTHSPSSSPSLGDADStipiSAR..LPGLSADNSDGMttTAAPTVRRWWASDHVQLLFRGIESSDAlsvASPETAkQRRLVVlaEARLFVQDRAK.F...RLLGTSSRVVdddVAFNARTGQFRL...YLRAEVghtvidTLVGRLRAIE.RLVGFLDAIRRESRVVHSQSVSLNRLVFSYSVGPGAKPQELTTEAAV...ASARAATSNGRWR..VTIDLSSSKQVR..LQLEDKCPHLrvadYLGR..IANNSSTLATLpffltaTLSLHR.ALDRMEDAWEPIVMRNIGMLSILPR...ALDWIVVRI...MLMTSGAGAAGAGGAGAAP.PPSARNVRQLALDIRLRTRRNEaMWQIRRVEEP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.20|      27|     353|       5|      31|       3
---------------------------------------------------------------------------
    5-   31 (48.97/28.46)	TNGTNHDRDAAAMNGVNG.DAA.AGAPSE
  359-  387 (42.22/23.55)	TQGLNNSRHWFIIGAHSGhDAAtADLPDE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32450 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) KTYGWTTVRHGGPSGPNQNSPPLPLARMDDVR
2) LQVTSMPPNLQTTQMIQIQQQRRAHAHAQAQAQAQAQAQAQAQSYQAQTARMG
3) LSTAAVASPYPGNSVEDSESASASASISSSTPR
4) MAALTNGTNHDRDAAAMNGVNGDAAAGAPSEAATSSTRMNNLPDRI
5) WQIRRVEEPSRSSSNNSSSSAPEDDLSKVMRR
573
1180
1129
1
1086
604
1232
1161
46
1117










Molecular Recognition Features






MoRF SequenceStartStop




1) RWWLVKL
639
645