<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32449

Description S-methyl-5'-thioadenosine phosphorylase
SequenceMDPGDYRTNVLSFNNFTSIDYEFLEPKTPSSENIRVSLRNIERLLRQDGRLAHLDTVRDGIWLFQGGKSSSNLSKPHKTENGVIDVLGIQLVVVEQGVFEPASLAKAKQSPHSVLNSASSNSSPSSSLENSGRAGFSVNSRAVQANAAHNASQEAFPSQGQKPLDRQDLTWPAPADLHERFISAVLGSLVSILCRDEGFIPLNPRTLILNQSIASSPADLTESYSKHTGAITLATLDISLTPLGTVIIKIYSDEALGLQSICASSLSNGQFERLAPGTMLWLAPGGNTAKFHAFSNQKGLPRTQTGKPSVTTPADSKLSELNELTVKSWQSKCIQWLSSKGIDTSYIDSGGWLFVQMLAGNSSLLGNESLATCNGSSVVPWPALLCFTSSNTAISRPLTNQQAAKQVTDPLSFAEEWFMSKIERSNTLEKRVRDRQNAEALSREQAEVDARALQSNSYSPVVLRRGSNAGAMYPTPPDAIHHPVGVTPVFDGAGSTPNNPNANPFAAQDGSAIATTSGVPDVDVDMWDTPNKKDRNNDTDGDLFGDLGGDMFGNDVTDADFSFFDEPDEVEPEVKTEIPVAANMSTITEDPVRKPAFVASLAGVEGMRPPPLKTKQPPDLDKRAIVGAMKPPRKVNTHEVVDTNFAGEKSGGITRTISPVQFDQESIFQRLVKDATSQKVQKRPRRESLFDKIDFENSLSLVDDKYGAQGLYSVSDQKGWLPVLGSGLPQTNYLSSRKKSHQNEFEVGKIPQLLLEDKMSENQEFDEAMDFMVDSDGMSTTSEQDDTSRSTDDTSAVPTTGFEKTWLTEDRPAAGMPSFDPMSIDFEQSSSTPQSAVGTQLPFPDLNATDWSLTSYFTTPEPEMLSSSLNDLECIATAQILVDQVVAGTLQVPWLSEQTRALNKTTAKGGLVRSVAKVARLFFKDLVSCTVKTFSEIQGVPVLNSGLRLPPRPINPFSIPLPQLELRRSDSKLSVLPSAISFWENLGLAPSGGTKDVLSVCVYPDLDGAQSGVTYFNEQIRNTYESFRLGTHEIIVARDLFSGHLPYPLETDPQNSFRNLATLRETVARLANSITSIFPEEKNFVIYFMYPTDNPTLLVHICSAFQHLFHLYRKALVDRKVQPSNELVLQLVPIDFVASSTSIPIPTPIEYGRLCLEVYGRCMDFASSAATPAIMLERPLPRGIDFKLNPTPSAAVLQEHTCLHIAYAQSADSRWITAVWTDNRGTQQMNASYCLGRKNEPISMSFSNVAAEIWDTTLDFVSSKRIHWRIFIAKVGIMETSEVETWIDLASKESDAQTKLTLLTVHTEPSLRLLPPALSLPAARDSTQTTTPVSTPQNSILSPDMSTPNPPTTTPSDQSSTVDPDPTTRLLLLSDQTHGLILSHRLSNSRSLFHPNPALVSGYVIKHSTPTPVLIEVNVIHGGREGNPRHFYEALLREVLTNYAGLGTLSRARGTTSTGDARPWHIAAAEKDPIKIAVIGGTGLQSLPGFTPIATVNPLTPWGYPSSPISVLSHNNVPVAFLSRHGLHHQFAPHEVPNQANIAALRSLGVRCVIAFSAVGSLQEEIKPRDFVVPDQVFDRTKGIRPFTFFEKGVVGHVGFADPFDAKLGEIVKKCGHSLAGDNIVLHDKGNLICMEGPQFSSRFESNYYRSLGGSVINMSALPEAKLAKEAELAYQMICMATDYDCWHSTEDVDVAMVMGHMKANGENAKRFVGAVLDALTKEESGEVVEARHLMGGTTGMIKFMTKAEGRGAEGVKNVEFLFPGVFDS
Length1769
PositionKinase
OrganismGlarea lozoyensis (strain ATCC 20868 / MF5171)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Helotiales> Helotiaceae> Glarea.
Aromaticity0.07
Grand average of hydropathy-0.267
Instability index43.85
Isoelectric point5.43
Molecular weight192959.32
Publications
PubMed=23688303

Function

Annotated function Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. 
ECO:0000256	HAMAP-Rule:MF_03155
GO - Cellular Component
cytoplasm	GO:0005737	IEA:UniProtKB-SubCell
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
S-methyl-5-thioadenosine phosphorylase activity	GO:0017061	IEA:UniProtKB-UniRule
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
L-methionine salvage from methylthioadenosine	GO:0019509	IEA:UniProtKB-UniRule
purine ribonucleoside salvage	GO:0006166	IEA:UniProtKB-KW
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats
>MDP32449
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.34|      24|      30|     460|     489|       1
---------------------------------------------------------------------------
  466-  489 (46.96/37.83)	GS.....NAGAMYPTPPDAIHHPVGVTPV
  494-  522 (36.38/15.32)	GStpnnpNANPFAAQDGSAIATTSGVPDV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     181.39|      60|      66|    1468|    1532|       2
---------------------------------------------------------------------------
 1471- 1532 (95.89/63.64)	KDPIKIAVIGGTGLQSLPGFTPIATV.NPLTPWGYpSSPISVLSHNNV..PVAFLSRhGL..HHQFA
 1537- 1601 (85.50/41.75)	PNQANIAALRSLGVRCVIAFSAVGSLqEEIKPRDF.VVPDQVFDRTKGirPFTFFEK.GVvgHVGFA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     272.98|     106|     281|     938|    1056|       4
---------------------------------------------------------------------------
  718-  771 (32.07/ 6.30)	KGwLPVLGSGLpqtnYLSSRKkshQNEFEVgKIPQLLLEDKMSENQEFDEAMDF........................................................................
  824-  893 (69.31/30.55)	...................................................IDF.EQSSSTPQSAVGTQLP...FPDLNATDwSLTSYFTtpepEMLSSSLNDLEcIATAQILVDQ.VVAGTLQVP
  938- 1048 (171.60/120.08)	QG.VPVLNSGL....RLPPRP...INPFSI.PLPQLELRRSDSKLSVLPSAISFwENLGLAPSGGTKDVLSvcvYPDLDGAQ.SGVTYFN....EQIRNTYESFR.LGTHEIIVARdLFSGHLPYP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     145.12|      35|      67|    1285|    1319|       5
---------------------------------------------------------------------------
 1285- 1319 (58.19/35.27)	TWIDLASK.ESDAQTKLTLLTVHTEPSLRLLPPALS
 1321- 1346 (36.21/18.72)	.....PAA.RDSTQTTTPVST....PQNSILSPDMS
 1354- 1387 (50.72/29.65)	TPSDQSSTvDPDPTTRLLLLSDQTH.GL.ILSHRLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     222.21|      56|      68|     259|     314|       6
---------------------------------------------------------------------------
  191-  243 (62.67/34.05)	.SIlCR...D...................................EG.FIPLNPRTLiLNQSIASSPADLtESYSKHTGAITLATLDISL.TPL
  259-  314 (101.25/59.84)	QSI.CASSLS...................................NGQFERLAPGTM.LWLAPGGNTAKF.HAFSNQKGLPRTQTGKPSVTTPA
  330-  410 (58.28/31.11)	QSK.CIQWLSskgidtsyidsggwlfvqmlagnssllgneslatcNGS..SVVPWPA.LLCFTSSNTAIS.RPLTNQ......QAAK.QVTDP.
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32449 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) EFDEAMDFMVDSDGMSTTSEQDDTSRSTDDTSAVPTTGFEKTWLTEDRPAA
2) PALSLPAARDSTQTTTPVSTPQNSILSPDMSTPNPPTTTPSDQSSTVDPDPTTR
3) RRGSNAGAMYPTPPDAIHHPVGVTPVFDGAGSTPNNPNANPFAAQDGSAIATTSGVPDVDVDMWDTPNKKDRNNDTDGDLFGDLGGD
4) VASLAGVEGMRPPPLKTKQPPDLDKRAIVGAM
5) VTDADFSFFDEPDEVEPEVKTEIPVAANMSTITE
764
1316
464
598
556
814
1369
550
629
589










Molecular Recognition Features






MoRF SequenceStartStop




1) FDEAM
2) LDKRAIV
765
620
769
626