Description | Mediator of RNA polymerase II transcription subunit 7 |
Sequence | MDEPQPEPRLTATFPSPPPFWKEFTEENLTRISELRVAQSGEASKKADPAASLPARILDLPPELRYLQPPEEPADGIYRSFGDLYNLKNPLPSLEEMGIENLYTPPSTPSHSGKYSDRALVLKRIAKSLLLNFLELLGILSHNPEQYDEKIKDLRTLFINFHHIINGYRPHQARESLILMMEEQLERSRAETRGIREGKEKVEVILEGLGKVKMGEEVVEGGEEVREEGWDVWEELDREFA |
Length | 241 |
Position | Middle |
Organism | Glarea lozoyensis (strain ATCC 20868 / MF5171) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Helotiales> Helotiaceae> Glarea. |
Aromaticity | 0.07 |
Grand average of hydropathy | -0.635 |
Instability index | 59.14 |
Isoelectric point | 4.90 |
Molecular weight | 27602.93 |
Publications | PubMed=23688303 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery.
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364060 ECO:0000256 ARBA:ARBA00003669 |
GO - Cellular Component | core mediator complex GO:0070847 IEA:EnsemblFungi mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | negative regulation of transcription by RNA polymerase II GO:0000122 IEA:EnsemblFungi positive regulation of transcription by RNA polymerase II GO:0045944 IEA:EnsemblFungi |
Binary Interactions |
Repeats | >MDP32447 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 87.22| 25| 35| 53| 78| 1 --------------------------------------------------------------------------- 53- 78 (41.34/22.43) LPArILDLPPELRYLQPPEEPADGIY 91- 115 (45.88/21.39) LPS.LEEMGIENLYTPPSTPSHSGKY --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) DLPPELRYLQ 2) GIYRSFGDLY 3) LTATF 4) PFWKEFTEENLTRISE | 59 76 10 19 | 68 85 14 34 |
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