<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32445

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDAGEYETNTLAITNIASISFRVYKQVASPTASLYPFSPSDVERTLRNDGHIVFCDSRRQGFWSFRLLRKDGSAIGSSPRTGMHNAIEIGPHKLAVVDEGAFEPSTLVKGRPAAPNPINTPSSSSSSGLSAPDAASRGAGAQPIPGGNTAPPQSSAAGGGGTTDTPHSNSAPPESRPFLAVPTKLVYNFFLSAVIASISSSYCLRANAIALNNRTFLLPPLDPLWDGEESSRTDTKCLVATLRVSLTTAGALLVNLSHTILQGMGCSEWACYAGIPPPGSTVLTAPWGNFATVRGTYPSLAPAGATGHVLGQTKRELSPSSIPQAWKVFAAKMLEMRGTSSSVLHDSSWLRVEFVLGDDVHGTKSVVILWPSVLCFWSLESSVVSAPSFQRLDPLNDLRAAFLEEARAEEAAFRPREDTREDKEDDVAMEDMHTVSSMDKGPLSDGPSPIGARQPVSLAGMIYPTPPDGILNLVGATPTFDGSVASPGNAASTTMPADLDPAAEDHEGGDDEFGSFWASSDPKREEAEQGFIEEPDTLFGDIVGDVVGDDVTDADFNFFDDKQPDGMHLPAYTPTGHIDDGMDLDTTSRRGDTSAYAHSDMETHLDAGATPGESIFTPAAAPEPSSAENADVKGESDISCQRPSSPVFAKPELRHARSNLGDASANGIKRPPSPFNAVTVFKRVRAMVEANKAQQNDGKHSLLDRRGKLFEGLQFTDFMIQNNKKYEQNGKFGFRWPHPESYMLSNISSATSPTAFRRPIKKQPELSDSSPEFASLISSITRGLKTSSLHAQSPLQMEDSGDASSSSSSYESSSEDSDGDEPLANSTAQRKIKTRPVAETAPSLEAATELSKAYREGVWDFPIARYFAEPMPSPTELNYTDDDIVDVAQIVTQQVTRATIRTSFDEDSGTNLQKTKLRRTLLQRIRYSMATLQDSLPACLDDAHRCSLKPYLEVPDIPLLMQPNRPHQRLSAASEPTRTNLWACSTPSVAIRRNESTLSILPTAVEFWEVLGLEPLHGTKDIAAVCMYPHYEGLAEEVASFLSRMRIVYESLRLGSHEPLPSKSNVVDGMLAFEVPSSYATPSGSAAARSEFPGSDQLHKLAQALAAEDTPGKSLVLYFVYCEEVTTSIVDACLAFQRLSHLYESAVTSRNSEPNDLVLQLIPASFIALETSLTVPSPTEMLRLSLEVYDRCASPRGPKPSPSFLLEQPPPRLLDLKLSSTPPVDVQRENSFIHVAYAFSADGRWVTAAWTDNSGWRQFSSAYWMGRKDAETSSNVFAAVAQEIWTNTCAIVSNLKVHWRVVIAKCSPMEQEEIDAWLELCKAETRVSISAVLVTVDTDPALELMPPIITASPAILSQLSAATPAPTPQASVFSPDQTGNPVTPAGTTPVGAPTPATPSGGSNGAAGTAAAPNSPAVASNPAANASNEAGAKLAAAGADPNTVADIEGNVVLVDITDNTWLAIASHRLNTSTTWVDMRHALVSGYVIKRGGIGRDEAPVVMEVNVIRAEGNPRVYDNVAREILTAYRSLGTLARARGILDNERDVRPWHVAAAERSAQGLCRWM
Length1564
PositionKinase
OrganismOphiostoma piceae (strain UAMH 11346) (Sap stain fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Ophiostomatales> Ophiostomataceae> Ophiostoma.
Aromaticity0.07
Grand average of hydropathy-0.283
Instability index51.29
Isoelectric point5.02
Molecular weight168030.02
Publications
PubMed=23725015

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP32445
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     112.94|      20|      20|     135|     154|       1
---------------------------------------------------------------------------
  115-  142 (23.82/ 7.32)	PNP.INT.PSSSsssglsapdaASRGAGAQ
  143-  163 (32.80/13.06)	PIPGGNTAPPQS.........sAAGGGGTT
  478-  498 (27.21/ 9.49)	PTFDGSVASPGN.........aASTTMPAD
 1366- 1383 (29.10/10.69)	PTPQASVFSPDQ..........T..GNPVT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.22|      25|      25|     826|     850|       2
---------------------------------------------------------------------------
  826-  850 (40.79/24.12)	STAQRK.IKTRPVAE.TAPSLEAATEL
  851-  877 (38.44/22.24)	SKAYREgVWDFPIARyFAEPMPSPTEL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.45|      25|      25|    1389|    1413|       3
---------------------------------------------------------------------------
 1389- 1413 (46.60/24.26)	PVGAPTPATPSGGSNGA..AGTAAAPN
 1415- 1441 (38.85/18.82)	PAVASNPAANASNEAGAklAAAGADPN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.73|      22|      25|     695|     719|       4
---------------------------------------------------------------------------
  695-  719 (35.63/28.77)	QNDGKHsllDRRGKL.FEGLQFTDFM
  721-  743 (40.11/24.48)	QNNKKY...EQNGKFgFRWPHPESYM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.78|      24|      26|     622|     646|       5
---------------------------------------------------------------------------
  622-  646 (39.16/27.41)	PEPSSAEnADVKGESDISCQRPSSP
  651-  674 (43.61/25.93)	PELRHAR.SNLGDASANGIKRPPSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.38|      18|      20|      44|      62|       6
---------------------------------------------------------------------------
   44-   62 (30.66/24.83)	RTLRNDGHIVfCDSRRQGF
   66-   83 (32.72/20.69)	RLLRKDGSAI.GSSPRTGM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.33|      10|      20|     500|     509|       7
---------------------------------------------------------------------------
  500-  509 (19.59/12.92)	DPAAEDHEGG
  521-  530 (18.74/11.96)	DPKREEAEQG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.58|      10|      22|     272|     281|       9
---------------------------------------------------------------------------
  272-  281 (20.69/11.68)	YAGIPPPGST
  297-  306 (18.89/ 9.81)	YPSLAPAGAT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.52|      21|      22|     750|     771|      10
---------------------------------------------------------------------------
  750-  771 (31.37/23.47)	ATSPTAFRRPIKKQpELSDSSP
  774-  794 (33.15/19.15)	ASLISSITRGLKTS.SLHAQSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.09|      18|      24|     379|     399|      11
---------------------------------------------------------------------------
  379-  399 (25.11/22.56)	LESSVVSAPSFQrldPLNDLR
  403-  420 (29.98/17.62)	LEEARAEEAAFR...PREDTR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.74|      13|     928|     541|     553|      16
---------------------------------------------------------------------------
  541-  553 (24.22/15.56)	DIVGDVVGDDVTD
 1445- 1457 (23.52/14.92)	DIEGNVVLVDITD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     166.28|      49|     234|     945|     996|      19
---------------------------------------------------------------------------
  945-  996 (80.47/44.58)	RCSLKPYLEVPDiPllMQPNRPHQRLSAASEPTRTNLWACSTPSVAIRRNES
 1183- 1231 (85.81/40.11)	RLSLEVYDRCAS.P..RGPKPSPSFLLEQPPPRLLDLKLSSTPPVDVQRENS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32445 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DADFNFFDDKQPDGMHLPAYTPTGHIDDGMDLDTTSRRGDTSAYAHSDMETHLDAGATPGESIFTPAAAPEPSSAENADVKGESDISCQRPSSPVFAKPELRHARSNLGDASANGIK
2) EEAAFRPREDTREDKEDDVAMEDMHTVSSMDKGPLSDGPSPIG
3) ILNLVGATPTFDGSVASPGNAASTTMPADLDPAAEDHEGGDDEFGSFWASSDPKREEAEQGFIEEPDTLFGDIVGDV
4) PTPQASVFSPDQTGNPVTPAGTTPVGAPTPATPSGGSNGAAGTAAAPNSPAVASNPAANASNEAGAKLAAAGA
5) SSLHAQSPLQMEDSGDASSSSSSYESSSEDSDGDEPLANSTAQRKIKTRPVAETAPSLEAA
6) STLVKGRPAAPNPINTPSSSSSSGLSAPDAASRGAGAQPIPGGNTAPPQSSAAGGGGTTDTPHSNSAPPESR
553
409
470
1366
787
105
669
451
546
1438
847
176










Molecular Recognition Features






MoRF SequenceStartStop




1) AFRRPIKKQ
755
763