<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32439

Description Transcription mediator subunit med12
SequenceMSRIMPLHYHAAQPELKQSHRRGRAPFGDFTWAIEPPPKGDAPASGSSATASAAASSPSNTSLNSGNGGSLRASIFKKSSALAYSGAASSSGLKDTDNSSGTTDKDGRPKPWHLDVPAGIPYYAIPSNRRFAGVTKGGRSLNQSHSQGAQTGRPGAPFASSRAVSGSGYGLANNSSSSQRNAGSSASTNTITAPGTGLVNTRNQKNAVVRYMDFNPWKGRHAEDRFTESTVRLGHYDRLQGNHSYTAEIGSARSWLPVLLKHKQNTAMLGQALGLANFFSRDKHHISPASQFKLPPRVTVTDTRRETWLRDLTNPAIPLRKLSRTIPHGLRGKVLLEQCMLKSVPVDRAMWLARCVGAQELRAFKRKGTPNVVALAESELRWLKDWTLTVQQFVEGFLVDMDLDTGTGKDRLQYAARFTRQLYLERLLDQDQFLNWMLAGLRNAAHVPAISSGSAPYFDLWLYIVEEYFHGIMIRRKPSSHLAVTLLSRLEYLSHFQSSKITSAQATKLLRAMIQAHPEAFVSLSVWPRYEKILTNVLLLPAPPRSAPNQSPPALDAIYTIRHRNNCLRPEMSPEMEQVINLLHPLDDALRSPKNFSSHFADLLRRDKKEAVPFVLRWCASIHRPGLAKVYIAARIINELCRGDAKLVTADVLAYLSSTRGPNSEAKQKKTSTTIMSKVHQEQLQLVQDKQSEGSKALYHLIGLLMMADLFLPAQYLTSLILLSRPSDSDEIVPQGQPHVRLIAELPVHLLDRSIANLRANHLRRLGYDADYETKDLESIISQLQKLWDEMAQQPPAEAAVSTSNIPSTETSKENPSHAGSRDCKILVRAFKLSHRIEERGRNVKMAAADWLSKNIVTPMHVYKPMPGSDARTGTEGSTNSVPTARSASMSASTARRISSSKPRANPPESTKARGNARDIFNVTNITLERADAIRCLIEKTDDLRLLSDFLFSLLSRPQIISVLAFCADTLNIHLAALLALGHGRTLYDKIMVRALSITVAAASGATTAFQTLLPPGTVIRPLMLALPALAEKMPSPEPNSLLIGANLQPKVVAPKDGTASARVESMKKHIDAGPAIAAEIRKRLADIDNRLSIATYDADCSPLSDGRGPLATQEEDTSAADEVRDEMIKIVSSGEGVDNATVDRLFGTIAMITQDRWRRLQPEPSRNAQAAPRNDLRLSAGLFARLRRLNTSHFDTIMVKWLKRLRTMRDRPSIRTLYPVYVVFGCLDTASLMATTADEQPREPGAMVQSPARSTWRTSYLQDVLTLLSVPIAEDHPMLTCDERRRFRVFQLEAPFKAPAGVAALVRNAVAEMTLWRHHQRQSSQSALPVQPAIVPRRAIDAFAVSRLLRTAALADAPKAGSALAKTADQTVRSGLWEMTTIALTRRIAPGRTPLETLRGLDIFAADVGQLALRLIVSPGPYASASERIKEADSLANLILRAVSEFQFSTLSVLYSLPDDMATSLKDHAQARFLEMVPSRKQLPTAAAAAAAAAAATPKIETNNELPSHNEIVDKLGELWCLLQEPSTTTAQKASQSTDRERVDGVKNAILREWLPALLSLILLHLPNRDSMLLSIEGSGRGGMSSLIAGLAAATAKKSDNKAPSQGTSPATFNSPANTTSNSNAGPNMTANLNAASSNSNYAMPGGAGPSLGATGLPRTSRDLEQEWVHAGACVALASLYMEVSSVADNTEGSPPKAHRLALQNRLFDTALLLADGLSDETRLHCVRTVRDAIASRDGMSGFGGAAGAGGGDIPPAVAYVLSSPTSSSIYYPRLYLERVPMPMFGRQQPSPPTRDWSHNSNASNAGHAGEHGGPGPGGLKRMGSGFSGVFPPNINDIRYKRVRFGLKTWDAVSDPSPSVQDNDTAVNLWLLDATKVLRQRRR
Length1884
PositionKinase
OrganismOphiostoma piceae (strain UAMH 11346) (Sap stain fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Ophiostomatales> Ophiostomataceae> Ophiostoma.
Aromaticity0.06
Grand average of hydropathy-0.302
Instability index53.13
Isoelectric point9.69
Molecular weight205245.38
Publications
PubMed=23725015

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32439
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     440.79|     146|     162|    1499|    1660|       1
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 1504- 1660 (224.59/129.75)	NNELPS...HNEIVDKLGELWcllQEPStTTAQKASQSTDRERVDGVKNAILREWL...PALLSLILLHL..PNRDSmLLSIEG.SGRGGMSSLIAG.LAAATAKKSDNKAPSQGTSPATF..NSPANTTSNSNAGP...NMTANLNAasSNSNYAMP.GGAGPSlgatGLPR
 1662- 1823 (216.20/95.89)	SRDLEQewvHAGACVALASLY...MEVS.SVADNTEGSPPKAHRLALQNRLFDTALllaDGLSDETRLHCvrTVRDA.IASRDGmSGFGGAAGAGGGdIPPAVAYVLSSPTSSSIYYPRLYleRVPMPMFGRQQPSPptrDWSHNSNA..SNAGHAGEhGGPGPG....GLKR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     297.44|     101|     162|     825|     949|       2
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  825-  949 (145.34/123.58)	KILVRAFklshrieergrNVKMAAADWLSK.........NIVTPMHVYKP.....MPGSDARTGTEGStNSVPTArSASMSASTARRISSSKPR..ANPPESTKARGNARDIFNVTNITLERADairCliektddlRLLSD
  990- 1106 (152.10/84.17)	KIMVRAL...........SITVAAASGATTafqtllppgTVIRPLMLALPalaekMPSPEPNSLLIGA.NLQPKV.VAPKDGTASARVESMKKHidAGPAIAAEIRKRLADIDNRLSIATYDAD...C........SPLSD
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.30|      31|     162|     570|     606|       3
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  570-  606 (47.28/45.58)	PEMSPEMEQVINL.LHPLDdalRSPKNFsshFADLLRR
  734-  765 (51.02/31.90)	PQGQPHVRLIAELpVHLLD...RSIANL...RANHLRR
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     214.67|      68|     696|     481|     552|       4
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  481-  552 (108.56/89.49)	HLAVTLLSRLEYL..SHFQSSKItsaQATKLLRAMiQAHPEAFVSLSVWPRYEKILTNVLLLPA...PPR..SAPNQSP
 1178- 1252 (106.10/74.83)	RLSAGLFARLRRLntSHFDTIMV...KWLKRLRTM.RDRPSIRTLYPVYVVFGCLDTASLMATTadeQPRepGAMVQSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     163.80|      58|     754|     639|     728|       5
---------------------------------------------------------------------------
  639-  701 (84.28/81.78)	ELCRGdAKLVTADV..LA.YLSSTRGPNSEAKQK.KTSTTIMSKVhqeqLQLVQDKQSEGSKALYHL
 1397- 1458 (79.53/36.73)	ETLRG.LDIFAADVgqLAlRLIVSPGPYASASERiKEADSLANLI....LRAVSEFQFSTLSVLYSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      84.72|      19|      74|      82|     100|       6
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   82-  100 (31.57/18.25)	LAYSGAASSSGLKDTDNSS
  158-  176 (31.31/18.03)	FASSRAVSGSGYGLANNSS
  187-  203 (21.84/10.06)	STNTITAPGTGLVNTRN..
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.90|      27|     753|      32|      62|       7
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   32-   62 (42.08/25.44)	W...AIEPPpkgdAPASGSSATASAAASSPSNTS
  788-  817 (43.83/18.29)	WdemAQQPP....AEAAVSTSNIPSTETSKENPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      31.28|       9|     231|     716|     726|       8
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  716-  726 (13.11/12.21)	YLTSliLLSRP
  950-  958 (18.17/ 9.44)	FLFS..LLSRP
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.45|      32|     160|    1137|    1174|       9
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 1137- 1174 (45.71/47.26)	GVdnATVDRlfGTIAMITQdrWRRLQPEPSRNA...QAA..PR
 1302- 1338 (49.74/30.11)	GV..AALVR..NAVAEMTL..WRHHQRQSSQSAlpvQPAivPR
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32439 with Med12 domain of Kingdom Fungi
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