<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32438

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMTDDMSLMLDDGMQGMSGDVPVSLGDVDVDDVDLFGGSVELGLSSHPPPPSKQLLLRVDEQRIRGCCQRIGWSKQGTIAAISEDGQSIDLRYLRADPETAAWGLSQPTSYSQFSAANTPTTFSGGPIVHLAWAATGHPELAVIDSVGRISILAFSITLNRPFPLRSWEADPIDDLNAVVGCYWLPIMPANKQYNLLHGPAIREPQGYRYETAYIHAFGPHHPNPAKSALMCVTSSAKLRLFFSQNSSVVHDTSIELENIASSDDLATHASICSEKGVLLIAMTTASRQLKVVRAVIHWNLPQHQDKPAPHQFSPVMQHKHAASTTWLQRGHEESQLDISSAQISHIEMLPSALPGPNQAWSPPLIITVRNYIPAGPGGLGGANPEPQSIINRWELLSESTPQPLHPAFEQLGFRPTNNSNAQAAIRLNRLAPVILSNKTVISVQTLQNGRALCFLFSDGTSQYRDRFTFEEIFQEPNLARISSLQHAGFELVDPTPCLAVALSPTGCSAAQLCEGGSVKWNTLKYTGPAFAASGPDPYDDILATAREFVEGPKFAYDWILDIVRVLKINVDYSEESHHDQLVRNNSLHLCLSILNHMGFRGEYKKRAFYSKFSMLALNSRNIVILITIASNTPGTLKEKLNPLDEPDVVDALAGCAKWALDLVSYICDCLFGLLEDSKFMSFLSSGGNFNDMVGYLQEKNEVALHLILCSSTRGFLSANVRTFRGLTDPAKLYFADYSVLEVEDDDHSLREKRLKHVQIDVFKRAELAPPRPTNNSSGTSNGHMNSFSQGPPMLRRCVRCAAVMDDISGSGSRPGYQFVLAQQRKCSCSGNWGLIPRTPASA
Length842
PositionTail
OrganismOphiostoma piceae (strain UAMH 11346) (Sap stain fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Ophiostomatales> Ophiostomataceae> Ophiostoma.
Aromaticity0.08
Grand average of hydropathy-0.184
Instability index41.36
Isoelectric point5.95
Molecular weight92345.72
Publications
PubMed=23725015

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32438
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     288.70|      91|     497|     233|     326|       2
---------------------------------------------------------------------------
  233-  326 (147.06/93.14)	TSSAKlrLFFSQNSSV.VHDTSIELE.........NIASSDDLATHASICSEKGVLLIAMTTASRQLKVVR.....AVIHWNLPQHQDKPApHQFSPVMQHKHAASTTW
  727-  832 (141.64/80.20)	TDPAK..LYFADYSVLeVEDDDHSLRekrlkhvqiDVFKRAELAPPRPTNNSSGTSNGHMNSFSQGPPMLRrcvrcAAVMDDISGSGSRPG.YQFVLAQQRKCSCSGNW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     125.48|      40|     497|     110|     153|       3
---------------------------------------------------------------------------
  110-  153 (64.44/49.26)	YSQFSAantpTTFSGGPIVHLAWAATGHP.....ELAVIDSVGRISILA
  609-  653 (61.03/37.08)	YSKFSM....LALNSRNIVILITIASNTPgtlkeKLNPLDEPDVVDALA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.81|      13|      15|     534|     546|       4
---------------------------------------------------------------------------
  534-  546 (25.80/14.06)	GPD.PYDDILATAR
  551-  564 (22.01/11.02)	GPKfAYDWILDIVR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     145.96|      40|     181|     183|     222|       5
---------------------------------------------------------------------------
  183-  222 (79.55/44.87)	WLPIMPANKQYNLLHGP.....AIREPQGY..RYETAYIHAFGPHHP
  360-  406 (66.41/36.33)	WSPPLIITVRNYIPAGPgglggANPEPQSIinRWELLSESTPQPLHP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.70|      11|      18|     469|     482|       6
---------------------------------------------------------------------------
  469-  479 (20.28/17.80)	FEEIFQEPNLA
  489-  499 (21.42/ 8.38)	FELVDPTPCLA
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32438 with Med16 domain of Kingdom Fungi
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