<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32435

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMANPPGAPGDPGPSTLFGERDPVFRPWPLPPKQPSNIADFVSRLKAQGIEFRELSDEGLRKQIEEEKKQAADGKNGANATDSDNKATKSKSANTDEAIERPKGREAMMQRRDEVIVALMNAVQSGAICLDLVSLLLSKDRPTQALQTLSNVRDKVGIGTLSAGRIANATQAARALQIRSRGGALSAADLQNLDETTRTNAERLLEHKTECVGWQLLAMDRASDMLQVAQKRLHTQMRREKRYWSEILAVQERGWCLSRVPGQRRVLRVKFGFSEAAPDLRPLGFAPMHRAKGKHVALDLSFLGPPAAIVLTLRKRDGSSDEIGRSHIPTRLPSSAALEDRILEARNTIFAKELWRELGREVRLLVSHDVVFRDNKIIFPAGAQTQGIVSLETLRLKPTAVDDSSAAATPSPKLDDMAEAICTSLHLLLTHGHREHYNKRSQPALPVDITPSPPAYCMLRTVVSNLKYEMALKHIAMCVSSVCGILHGVGQTGARFTLYERPITPAVMSMPSTATGRAGVQPSASESLCSAFLTQREFSFEYIINAHTRILIRSRTYIAPIKVQYLVQLLPPLPGSGSAAKNPLLDTFPPADGYSTLHDVATYIQDATTHVLAERALAIARTWEAKSGNGKDSVWAMTVDGMAIRHTKSASWTLRLGMAPLPVASAAESSRGKLGKLEEEDAEIYQIDSVVDGADLPPVQVDSPLEQLPPFELRVDASWPHESNDSAVCKTWAWSAASLQQAAQGSVDLESIIEGCISATLKPKTSSQVN
Length769
PositionHead
OrganismOphiostoma piceae (strain UAMH 11346) (Sap stain fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Ophiostomatales> Ophiostomataceae> Ophiostoma.
Aromaticity0.05
Grand average of hydropathy-0.290
Instability index46.96
Isoelectric point8.53
Molecular weight83901.78
Publications
PubMed=23725015

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364140
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP32435
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     176.89|      52|      55|     123|     176|       1
---------------------------------------------------------------------------
   99-  133 (41.48/24.28)	...ERP.KGREAMMQRRDEVIV.................ALM.............navQSGAI.CLDLVS
  136-  191 (70.64/50.47)	LSKDRPTQALQTLSNVRDKVGIGTLSAGRIANATQ.AARALQ.............irsRGGALsAADLQN
  192-  259 (64.76/39.57)	LDETTRTNAERLLEHKTECVGWQLLAMDRASDMLQvAQKRLHtqmrrekrywseilavQERGW.CLSRV.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.36|      25|      38|     408|     432|       2
---------------------------------------------------------------------------
  408-  432 (44.79/29.26)	TPSPKLDDMAEAICTSLHLLLTHGH
  449-  473 (45.57/29.90)	TPSPPAYCMLRTVVSNLKYEMALKH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.67|      12|     372|     275|     287|       4
---------------------------------------------------------------------------
  275-  287 (19.49/14.83)	AAPDLRpLGFAPM
  649-  660 (24.17/12.90)	ASWTLR.LGMAPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     129.53|      43|     296|      18|      63|       5
---------------------------------------------------------------------------
   18-   63 (63.57/53.39)	GERDPVFRPwPLPPKQPSNIAdFVSR.LKAQGIEF.RELSDEgLRKQI
  317-  361 (65.95/39.83)	GSSDEIGRS.HIPTRLPSSAA.LEDRiLEARNTIFaKELWRE.LGREV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32435 with Med17 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LSDEGLRKQIEEEKKQAADGKNGANATDSDNKATKSKSANTDEAIERPKGREAMMQR
2) MANPPGAPGDPGPSTLFGERDPVFRPWPLPPKQPSNIADFV
54
1
110
41










Molecular Recognition Features






MoRF SequenceStartStop




1) NIADFVSRLKA
2) TLFGERDPVFRPWPL
36
15
46
29