<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32424

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMLTDSSLINTIILSGISNIRYKCYVHSYPKSALLSFLTRESFHANLSYIDSPESHNAIIDAYKHLIALNIPATWHILSNPKTDKDSVTLELWLFWFDNKHTQVIETDARLKELQESKSGTFNWSQITSKNGLSPTSSPQLTLSKSDNITLVPGTEYKLFIKSIRNLVQHVMIHKRHAFVLGEFFVFPETYQDQGNVMKDEIANDDPMSVKNTLLACMYNVYFTTSNLVFQPNTRRMRLRPLSTVDLYTKNLKVLLCPTGEHARIVSFHSLPADMQSKVLNQWAEFYDMPVSLVTQKKEYMPSLITIRTASQDTVVYPSALVFVPTDTKQSPAAVAGMNGIMGLNHGLTEDLGAKASRMAYYEKLRLNTQEKDATIDYWSYRDPIIHIGSSVFHALSSIDAKYQQDQMLLHRALIEPVVGSPIMNAKSVVPTNYDSPLLASGLHRKSITPPAPSAQNECSMQLSEYVTSLFHDNTSGDDVMLELLQDPSVAAVQRNDSLDIDGGSHLSALLNKTLMIDSTDNLPLSTTSNDAANQPQLMEPHPTVIQPHADAMPTKDEPQTLQSPLEDFNLMYDLEGTRLHKTDAWDADDGFGDLDLDVTDADFDFFETPAVAAPPALPPSPPPIPATELNVLNIIPMDIDSPKTDPAQVEVKQKSLEQDMVMADVQVSEIKSKPTPNNNDSLFTPFVVSNDSTENVSTTATLEETSYTATPKIPDTFTLQKRASYQKSTPEPFSFVPRDFLPVPVKATVNDAKYGAGGKFMYNPSKDQSKADGNGFAISKSKESVFYSPDYVPIAPKKKLTKSKQQQVSDMEADPSLETSWSNNVRNQSSSDKGSSSNSSESSSSSNSSSSNSSSSDSDSFTTDDGEEDSQDSATESESDIDKMDENISSEGMVEKRFKALKKFQKSIIYSQIKATPAPLPTDRLQYLDYDTPFAPILAYGSIKPIKWRHSKAMEESLAHLCEQAVLGGYPLAGGLAEVSENGGEIEGEPAKVLVARRNNLMQMTRGVVTHMPTLQADVFNMTTEFRDILQDIFIEAVDENDASGMDLITTPDALEPVSYPHGPLLGKIGIKGPLNIQEYYDLNESHNQGHSKYGKYQVKKRRPDEPNLDIIKKPEIVVSRHEDNLEGSSTMIPFWEKLGLDPYSAKKQIKYFVVYPNNSDIESSVRRFFKSLGNVYEACHLGKHEPGYAGAYLDGLVPVSVTNSNLNESSVRQRLKNYEETCEALGRYLAIDEEQQKHQYHTQNYYTVIYIVNPGPHMSSYLDMCRCFYKLKEAYHRIAHKNFSDEQPRIALQLMPIDHILRPSAFGGYTMLGMKDIAFSVYTKCFTRVKSPNQESWVDLYAPAFVLSKPLQRTIKFKLNDIRPFPTIMEQNAVLHMAYCFSYDRAWMAVVWMDDRGELLEYDLFSRKTAFKEAWNRTLEIAQRTAFPWTVVIAKLGLMFNDELLYWLRYVSTAIEHRVTIVAMDLESGLNLHFNACYPNRDAAAQQHDPQQPSFLDAQGKTHTTASGMTYAREQGKHHQTNSNRSTDVGEAQILLLNHRISYSQKRERAYKGILRPEAITEKENWMTPLATGYLIHHSLPNKNVNPCMEQFNNEAFVAEIHLLYNQTEISAYSTLQDTIKRLYALSFTNPIPSSHTCIPYHVVLAERLSRVLLVVDDSIK
Length1662
PositionKinase
OrganismMucor circinelloides f. circinelloides (strain 1006PhL) (Mucormycosis agent) (Calyptromyces circinelloides)
KingdomFungi
LineageEukaryota> Fungi> Fungi incertae sedis> Mucoromycota> Mucoromycotina> Mucoromycetes> Mucorales> Mucorineae> Mucoraceae> Mucor.
Aromaticity0.09
Grand average of hydropathy-0.431
Instability index49.21
Isoelectric point5.55
Molecular weight186747.59
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32424
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.51|      12|      14|     495|     506|       1
---------------------------------------------------------------------------
  495-  506 (21.68/13.92)	NDSLDIDGGSHL
  511-  522 (20.83/13.07)	NKTLMIDSTDNL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     311.13|     102|     552|     375|     493|       2
---------------------------------------------------------------------------
  375-  493 (152.52/108.15)	IDYWSYRDPIIHIGSsvfhaLSSIDAKYQQ..DQMLLHraLIEPVV..GSPIMNAKSVVPTNYDSpllASGLHRKSITppapsAQNECSMQLSEYVTSlfHDNTSGDDV..ML....ELLQDPSVAAVQ
  928- 1039 (158.61/78.98)	LDYDTPFAPILAYGS.....IKPIKWRHSKamEESLAH..LCEQAVlgGYPLAGGLAEVSENGGE...IEGEPAKVLV.....ARRNNLMQMTRGVVT..HMPTLQADVfnMTtefrDILQDIFIEAVD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      69.65|      15|      16|     693|     707|       3
---------------------------------------------------------------------------
  693-  707 (23.70/12.08)	TENVSTTATLEE.TSY
  710-  725 (21.84/10.55)	TPKIPDTFTLQKrASY
  740-  754 (24.11/12.42)	FLPVPVKATVND.AKY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     136.71|      42|     552|     529|     576|       4
---------------------------------------------------------------------------
  529-  576 (66.01/50.98)	NDAANQPQLMEPHPTVIQPHADAmPTKD...EPQTLQSPLEDfnlmyDLEG
 1084- 1128 (70.70/38.85)	NESHNQGHSKYGKYQVKKRRPDE.PNLDiikKPEIVVSRHED.....NLEG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     435.11|     126|     141|    1173|    1302|       5
---------------------------------------------------------------------------
 1173- 1278 (144.51/131.82)	.................................................LG......NVYEACHLGK......HEPGYAGAYLDGLVPVSVTNSNLnESSVRQRLKNYEETCEALGRYLAIDEEQQKHQYhTQNYYTVIYIVNPGpHMSSYlDMCRCFYKLKEAYHR
 1279- 1418 (196.88/153.57)	IAHKNFSDEQPRIA.LQLMPIDHIL..............rpsafggytmLGmkdiafSVYTKCFTRV......KSPNQE.SWVDLYAPAFVLSKPL.QRTIKFKLNDI.RPFPTIMEQNAVLHMAYCFSY.DRAWMAVVWMDDRG.ELLEY.DLFSRKTAFKEAWNR
 1422- 1534 (93.73/66.97)	IAQRTAFPWTVVIAkLGLMFNDELLywlryvstaiehrvtivamdlesgLN......LHFNACYPNRdaaaqqHDPQ.QPSFLDAQGKTHTTASGM..TYAREQGKHHQTNSN...RSTDVGEAQ..........................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.20|      10|      15|     299|     308|       7
---------------------------------------------------------------------------
  299-  308 (18.08/ 9.13)	YMPSLITIRT
  316-  325 (18.12/ 9.16)	YPSALVFVPT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.78|      11|      15|     757|     767|       8
---------------------------------------------------------------------------
  757-  767 (21.75/13.14)	GGKFMYNPSKD
  773-  783 (19.03/10.55)	GNGFAISKSKE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32424 with Med13 domain of Kingdom Fungi
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