<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32414

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMLTDSSLTNILVVSGVSQIRYRVYNQHITRESLETFLSHSPEDIINKDMILLRAYTEMVALSIPSLWRVHSESNEPGKDLELELWVFWFDERHTGKIDANDNLYALDETKVGSFTWENAYSKIQSPTASPGASSTQSNTSIPVTVSDEYKWFIKSVRNLIHIQMKRNGAFPLGEFYIFPNTDQDVIADVKASNASTPPSLLKLTQSVLCCSYSIYLASTNLIFQPNTRRMRLRPITAQTIRARGKKVIISPTGETMLIANNNTQLLSPQLEETILKKWSLMLDIPYTNLIQCASPQQHASHDRSSQPQPQLKQQTSHQLPNLVAIKSPTLGDESYYYPSCLIFVSSSSKISPTAMAGVNGLFSFNQGFSEDLGDKWHRWAWSERISNYWEYTCPREATTAAVLDTLSMDNGQNNNIGLLQKAINEPVIASPLMATKSVATPGSATGNQRNEMSTPSSSTNNCDDDDQQQPQQQQQRLKHQLHQRSKSKYQSDLSLVDFAMAHFSVPNSTDELVEYPIMSHNTPVMHQSNDNQNQSLSQQQQQQQQQQQQPNHQQHQLQQQQLQDHQNNVAAISSNKAANQSTYQSPQMPNLELDAYGMVESMDVDNMVLDIPNRWTDDGMDDLDNFDFGVTEEDFDFFESSGPTSVPATATANALTSMPPLSLQQVQPTTMEASALSADNQLLLMQEIKPEDIDITSDFDSGLMDLDQKQQQAILDTDLDSQQNDLSLTPLQVGMAQHDPFNSSTTATDLAKQEEQKQMAQPLPQFQDYHQQLFVPPQFAPIKMESVVNDAKYIQGGKFTYPAQDNQPLTKRKQSTDYRPDYVPVMRSSKKNKRKSSKLLLLDTINKENKPLDLMDVMMTKDEPQPNSKSTTQDLTLTSSSSSEEEDSSSSGQSSTEDDDSDDEAYDENHSVDDYNDDNEDISTKITRTMKSLSLAQSKFIGKLTRIDTPTETMKKKLDVDQIMMDYDTPFARAVTDSVIRTAGARIDVNEHEEIKALDYLCQQAVMGGYPFSGGIEAMSSNGFEANEGESAKVVIARRRNLLQKYNGDAIHVPSTPSDVEFMNQNFKHVLSDIFYQQKRFSNSDMDTMCIDSLPLPASVTVKGPLNVQDYYELSETNQAHSKYGKYQVKKRRPAEPNLGTLQPPNITVSRQDDMIEGTSKLIMFWEKLRLEPYSLKKQVNYFVVYPKNESIENGITHFFKGLSTVYETCQLGIHHPAANIGPYRRGLVPVTLLPQLENESFQDRQLRSYMAECQNLGSTLGSAMPENVHIVIYMINPATHLASHLDLSRCFSKLKAAYSTSPIALGPRASDKTRARLVLQLMPIEHVLRSTSFGGCLKFGLKEIAFSVYSKCHSIVSRQHQTTISSKQDPHPVSDLYAPPFVLSKPVPSQIHFKLKRAISAFPSILENHAVLHMAYTFSLDKRWMIIVWTDNRGEMVEFAVLDNHRHHLPLSSVFEEAWIRTKQISKRTGFAWTFVICKMGLVFEDELTAWISCLPSNEHVAIVSLDVESTLYVNTTNVDTMMNEMHTPTDTLNTSTPTMMNTASTAKKMFSDTHEDGQTKALLLNHRVAYSNKRERMSYGMLGLDSMTKEDWMIPLASGYMIHTPPTTENPNNELFNCNPLVLEIHLVYNQTNHSAYSTLRDIIKKYHALSFVNVMPSNSNCFPIHIALVERLSRILLVVHS
Length1684
PositionKinase
OrganismMucor circinelloides f. circinelloides (strain 1006PhL) (Mucormycosis agent) (Calyptromyces circinelloides)
KingdomFungi
LineageEukaryota> Fungi> Fungi incertae sedis> Mucoromycota> Mucoromycotina> Mucoromycetes> Mucorales> Mucorineae> Mucoraceae> Mucor.
Aromaticity0.08
Grand average of hydropathy-0.509
Instability index53.46
Isoelectric point5.51
Molecular weight189873.51
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32414
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     189.86|      55|      71|     455|     525|       1
---------------------------------------------------------------------------
  455-  509 (99.42/67.55)	PSSSTNNCDDDDQQQPQQQQQR.LKHQLHQRSKSKYQSDLSL..VDFAMAHFSVPNST
  528-  563 (51.71/18.60)	SNDNQNQSLSQQQQQQQQQQQQ.PNHQQHQLQQQQLQ.....................
  708-  744 (38.73/ 8.90)	................QKQQQAiLDTDL....DSQ.QNDLSLtpLQVGMAQHDPFNSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.59|      15|      15|     856|     870|       2
---------------------------------------------------------------------------
  856-  870 (26.22/18.63)	DVMMTKDEPQPNSKS
  874-  888 (22.36/14.44)	DLTLTSSSSSEEEDS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.99|      15|      15|      90|     104|       3
---------------------------------------------------------------------------
   79-   97 (19.40/ 9.05)	DLELELWvfwfDERHTGKI
   98-  114 (20.59/10.07)	DANDNLY..alDETKVGSF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     201.73|      63|     838|     359|     427|       4
---------------------------------------------------------------------------
  359-  427 (103.41/82.32)	NGLFSFNQGFSE.....DLGdkWHRWAwsERISNYWEYTCPreATTAAVLDTLSMDNGQ.......NNNIG.LLQKAINEPV
 1194- 1269 (98.32/60.25)	NGITHFFKGLSTvyetcQLG..IHHPA..ANIGPYRRGLVP..VTLLPQLENESFQDRQlrsymaeCQNLGsTLGSAMPENV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      99.99|      30|     799|     276|     345|       5
---------------------------------------------------------------------------
  306-  336 (49.54/62.75)	QPQPQLkQQTSHQL...PNLVAIKSPTLGDESYY
  761-  793 (50.45/ 7.53)	QPLPQF.QDYHQQLfvpPQFAPIKMESVVNDAKY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.25|      10|     225|     121|     131|       7
---------------------------------------------------------------------------
  121-  131 (16.12/14.02)	SKIqSPTASPG
  348-  357 (20.12/11.80)	SKI.SPTAMAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.98|      22|     838|     594|     615|       8
---------------------------------------------------------------------------
  594-  615 (42.60/30.89)	DAYG.MVESMDVDNMVLDIP......NRW
 1432- 1460 (32.38/21.52)	DNRGeMVEFAVLDNHRHHLPlssvfeEAW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.54|      29|     269|     621|     700|       9
---------------------------------------------------------------------------
  170-  198 (52.92/12.49)	FPLG....EFYIFPNTDQDVIADVKASNA..STPP
  626-  660 (43.62/79.24)	FDFGvteeDFDFFESSGPTSVPATATANAltSMPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.14|      15|     269|     685|     700|      10
---------------------------------------------------------------------------
  664-  681 (19.99/ 7.65)	QQVQPTTMEasaLSADNQ
  686-  700 (25.15/11.06)	QEIKPEDID...ITSDFD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.45|      14|      15|     238|     251|      12
---------------------------------------------------------------------------
  238-  251 (23.14/15.11)	QTIR.ARGKKVIISP
  254-  268 (19.31/11.27)	ETMLiANNNTQLLSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.01|      29|      41|     946|     975|      15
---------------------------------------------------------------------------
  946-  975 (46.88/36.02)	RIDTPTETMKKKLD..VDQIMMDyDTPFARAV
  986- 1016 (48.13/31.38)	RIDVNEHEEIKALDylCQQAVMG.GYPFSGGI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32414 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IQGGKFTYPAQDNQPLTKRKQSTDYRPDYVPVMRSSK
2) KPLDLMDVMMTKDEPQPNSKSTTQDLTLTSSSSSEEEDSSSSGQSSTEDDDSDDEAYDENHSVDDYNDDNEDISTKITR
3) LDQKQQQAILDTDLDSQQNDLSLTPLQVGMAQHDPFNSSTTATDLAKQEEQKQMAQPLPQFQD
4) LMATKSVATPGSATGNQRNEMSTPSSSTNNCDDDDQQQPQQQQQRLKHQLHQRSKSKYQSDL
5) MVLDIPNRWTDDGMDDLDNFDFGVTEEDFDFFESSGPTSVPATATANALTSMPPLSLQQVQPTTMEASALSADNQLL
6) VPNSTDELVEYPIMSHNTPVMHQSNDNQNQSLSQQQQQQQQQQQQPNHQQHQLQQQQLQDHQNNVAAISSNKAANQSTYQSPQMPNLELDAYG
794
850
706
432
607
505
830
928
768
493
683
597










Molecular Recognition Features






MoRF SequenceStartStop




1) DYVPVMR
821
827