<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32411

Description CMGC/CDK/CDK8 protein kinase
SequenceMSMAEYKMKRDACRPKVLDKYEIIGFISSGTYGRVYKARSRNKDDHREFAIKKFKPDREGDTHHYVGISQSACREIALCRELKHDNVVSLEEVLLEDKAIFMVFEYAEHDFLQIIHYHLHTERKPILEVVVKSILWQLINGVAYLHSNWVLHRDLKPANVLLTSEGIVKTGDLGLARLFNKPLQPLFNGDKVVVTIWYRAPELLFGSRHYTKAVDMWAVGCIFGELLALKPIFKGEEAKMDGKKNVPFQRSQLTKIFEIMGTPTKERWPTIDQLPDYPHLSSFPQCPNNLKQVYQMMLSPKSEAGFNLLSALLEYDPAKRITAEKALNHPYFQEDPKPVMNVLAQQGVEYPLRRITQEDNDIKASKQVQPNKDDHSNRMTKKPRNA
Length386
PositionKinase
OrganismMucor circinelloides f. circinelloides (strain 1006PhL) (Mucormycosis agent) (Calyptromyces circinelloides)
KingdomFungi
LineageEukaryota> Fungi> Fungi incertae sedis> Mucoromycota> Mucoromycotina> Mucoromycetes> Mucorales> Mucorineae> Mucoraceae> Mucor.
Aromaticity0.09
Grand average of hydropathy-0.473
Instability index42.12
Isoelectric point9.00
Molecular weight44578.99
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:EnsemblFungi

GO - Biological Function
ATP binding	GO:0005524	IEA:InterPro
cyclin-dependent protein serine/threonine kinase activity	GO:0004693	IEA:EnsemblFungi
RNA polymerase II CTD heptapeptide repeat kinase activity	GO:0008353	IEA:EnsemblFungi

GO - Biological Process
negative regulation of filamentous growth	GO:0060258	IEA:EnsemblFungi
negative regulation of transcription by RNA polymerase II	GO:0000122	IEA:EnsemblFungi
nuclear-transcribed mRNA catabolic process, non-stop decay	GO:0070481	IEA:EnsemblFungi
phosphorylation of RNA polymerase II C-terminal domain	GO:0070816	IEA:EnsemblFungi
positive regulation of transcription from RNA polymerase II promoter by galactose	GO:0000435	IEA:EnsemblFungi
protein destabilization	GO:0031648	IEA:EnsemblFungi
response to oxidative stress	GO:0006979	IEA:EnsemblFungi









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32411
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.50|      18|      32|     306|     324|       1
---------------------------------------------------------------------------
  306-  324 (26.94/24.74)	FNLLSAL.LEYdPAKRITAE
  340-  358 (28.56/20.19)	MNVLAQQgVEY.PLRRITQE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.65|      23|      30|     119|     145|       2
---------------------------------------------------------------------------
  119-  145 (32.74/33.71)	LHTERKP..IL...EVVVKSilWQLinGVAYL
  151-  178 (30.91/18.86)	LHRDLKPanVLltsEGIVKT..GDL..GLARL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.85|      30|      34|     231|     263|       3
---------------------------------------------------------------------------
  234-  263 (51.56/33.05)	KGEEAKMDGKKNVP....FQR..SQLTKIFEIMGTP
  265-  300 (46.29/21.60)	KERWPTIDQLPDYPhlssFPQcpNNLKQVYQMMLSP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32411 with CDK8 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) RRITQEDNDIKASKQVQPNKDDHSNRMTKKPRNA
353
386










Molecular Recognition Features






MoRF SequenceStartStop




1) YGRVY
2) YPLRRI
32
350
36
355