<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32411

Description CMGC/CDK/CDK8 protein kinase
SequenceMSMAEYKMKRDACRPKVLDKYEIIGFISSGTYGRVYKARSRNKDDHREFAIKKFKPDREGDTHHYVGISQSACREIALCRELKHDNVVSLEEVLLEDKAIFMVFEYAEHDFLQIIHYHLHTERKPILEVVVKSILWQLINGVAYLHSNWVLHRDLKPANVLLTSEGIVKTGDLGLARLFNKPLQPLFNGDKVVVTIWYRAPELLFGSRHYTKAVDMWAVGCIFGELLALKPIFKGEEAKMDGKKNVPFQRSQLTKIFEIMGTPTKERWPTIDQLPDYPHLSSFPQCPNNLKQVYQMMLSPKSEAGFNLLSALLEYDPAKRITAEKALNHPYFQEDPKPVMNVLAQQGVEYPLRRITQEDNDIKASKQVQPNKDDHSNRMTKKPRNA
Length386
PositionKinase
OrganismMucor circinelloides f. circinelloides (strain 1006PhL) (Mucormycosis agent) (Calyptromyces circinelloides)
KingdomFungi
LineageEukaryota> Fungi> Fungi incertae sedis> Mucoromycota> Mucoromycotina> Mucoromycetes> Mucorales> Mucorineae> Mucoraceae> Mucor.
Aromaticity0.09
Grand average of hydropathy-0.473
Instability index42.12
Isoelectric point9.00
Molecular weight44578.99
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:EnsemblFungi

GO - Biological Function
ATP binding	GO:0005524	IEA:InterPro
cyclin-dependent protein serine/threonine kinase activity	GO:0004693	IEA:EnsemblFungi
RNA polymerase II CTD heptapeptide repeat kinase activity	GO:0008353	IEA:EnsemblFungi

GO - Biological Process
negative regulation of filamentous growth	GO:0060258	IEA:EnsemblFungi
negative regulation of transcription by RNA polymerase II	GO:0000122	IEA:EnsemblFungi
nuclear-transcribed mRNA catabolic process, non-stop decay	GO:0070481	IEA:EnsemblFungi
phosphorylation of RNA polymerase II C-terminal domain	GO:0070816	IEA:EnsemblFungi
positive regulation of transcription from RNA polymerase II promoter by galactose	GO:0000435	IEA:EnsemblFungi
protein destabilization	GO:0031648	IEA:EnsemblFungi
response to oxidative stress	GO:0006979	IEA:EnsemblFungi









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32411
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.50|      18|      32|     306|     324|       1
---------------------------------------------------------------------------
  306-  324 (26.94/24.74)	FNLLSAL.LEYdPAKRITAE
  340-  358 (28.56/20.19)	MNVLAQQgVEY.PLRRITQE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.65|      23|      30|     119|     145|       2
---------------------------------------------------------------------------
  119-  145 (32.74/33.71)	LHTERKP..IL...EVVVKSilWQLinGVAYL
  151-  178 (30.91/18.86)	LHRDLKPanVLltsEGIVKT..GDL..GLARL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.85|      30|      34|     231|     263|       3
---------------------------------------------------------------------------
  234-  263 (51.56/33.05)	KGEEAKMDGKKNVP....FQR..SQLTKIFEIMGTP
  265-  300 (46.29/21.60)	KERWPTIDQLPDYPhlssFPQcpNNLKQVYQMMLSP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32411 with CDK8 domain of Kingdom Fungi
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