Description | Mediator of RNA polymerase II transcription subunit 8 |
Sequence | MEQSQLQAQLDPNTYQELDALRGKLWSLQETFSSHLTYLKEPKFPFAWPDLLNKFNILTARFASLSEDFYSYTEKGSNATLPKLMVHPYIPTTTEQETNILSVLLRTKLIPDIERLEAETQATIAQELLSDNGAMATASQSTHNVDDEQLIYSQLKQWNHLLERHDRLAVDATNFISELSTDHRPNFMLRYEDQIEEDEDEDEEMEEEQEWEKMGFPSEEIWKKWKLECLMNFYSSGKSEVIGSDLKKLATATKK |
Length | 255 |
Position | Head |
Organism | Mucor circinelloides f. circinelloides (strain 1006PhL) (Mucormycosis agent) (Calyptromyces circinelloides) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Fungi incertae sedis> Mucoromycota> Mucoromycotina> Mucoromycetes> Mucorales> Mucorineae> Mucoraceae> Mucor. |
Aromaticity | 0.09 |
Grand average of hydropathy | -0.689 |
Instability index | 57.48 |
Isoelectric point | 4.61 |
Molecular weight | 29680.82 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364144 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP32409 No repeats found |
MoRF Sequence | Start | Stop |
1) EKMGFPSEEIWKKWKLECLMNFYSSG 2) EVIGSDLKKLATA 3) MLRYE | 212 240 188 | 237 252 192 |
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