<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32408

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMSQEPTKKRIKLSLEPAIDNNVVDITNAGQEILKTDTSLPEKLMQSVDRIWFERGEWKDISEKSLMASIKKRKQQPELKDEEEEGEGEEEHELQTENALPSQSLPPGFDVAKLRESVINKLFHAKSEIDVALDVINILAAGNRGSSAAVKDLVLPAGSLTATYVTKPKQTTKAQLESVQLNLGLKRKKQKQASDFLKKSAAALKHLVEKEHVFWDEALDLRRNNWQMQANSNAGASFFVQYGYTEVGSDFNEQSIGELKRSSDEDDDGSNLLQMSLPHGTCRKVAVRISKSHMGKLGLGGQNEFSEGILGILEEQQGAYAADQDKERSTFNQGKEGGAAVKVYSNTMLGTSHSKIQNQLAEAHSTVFDAELFSDILAEAQALNSNVRFPDDEIVINIDGQIDLHVSKVPVVAANHTPAKLTSQQIISRSIDLSFRLLLLQHQRFNLWKTKAKILSSNHKIHQLLSDTAVGSSTASSAATPVNTTATTNAPTPTNSGNGATGAPAPTPTTATSGNVLPIVGTSSSVSTASRARTRLAATATTATATRDLPSQIPILSPIMSLTRFWVQFDRIRHVTNKTIREYRNLSISVHYKFADDASQSQSKTRPYDTYPGYGQVALCLGLGILRGPSLHFNLSQSGSISVCLPQTTVVLQNVSEFEAFLSREVKVICLRTVCDVANDMIKSQQLWQVDQVDEAIHGSIWWQSTNHWRNITVRLLNSHLEFRLTTTQDLEESVHMLELNQTITPMHFKERVCVIIKQITEDAQREQ
Length767
PositionHead
OrganismMucor circinelloides f. circinelloides (strain 1006PhL) (Mucormycosis agent) (Calyptromyces circinelloides)
KingdomFungi
LineageEukaryota> Fungi> Fungi incertae sedis> Mucoromycota> Mucoromycotina> Mucoromycetes> Mucorales> Mucorineae> Mucoraceae> Mucor.
Aromaticity0.06
Grand average of hydropathy-0.403
Instability index43.22
Isoelectric point6.34
Molecular weight84712.48
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32408
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     100.22|      24|      26|     470|     495|       2
---------------------------------------------------------------------------
  467-  492 (38.86/27.51)	TAVG.SSTASS.....AATPvnTTATTNAPTP
  493-  517 (39.95/22.29)	TNSGnGATGAP.....APTP..TTATSGNVLP
  526-  549 (21.42/ 8.74)	......STASRartrlAATA..TTATATRDLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.68|      17|      36|     294|     310|       3
---------------------------------------------------------------------------
  294-  310 (30.08/20.59)	GKLGLGGQNEFSEGILG
  333-  349 (29.60/20.15)	GKEGGAAVKVYSNTMLG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.72|      11|      35|     182|     192|       4
---------------------------------------------------------------------------
  182-  192 (18.89/13.48)	LGLKRKK.QKQA
  218-  229 (15.83/10.04)	LDLRRNNwQMQA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32408 with Med17 domain of Kingdom Fungi
Unable to open file!