<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32404

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMETSEYETNTLSINNIASVAFRIYEPPPDQSHGFQSSALEIQSSLRDQGKLVSYDAERVGIWIFQIVSKDGTSSLVSSAPGSSLEASGYTLGMVEEGTLEPVALQKSRIPGNTTQNAPNNTASTSSPAEANSRNPLISPTQVAGGALPDGGSQSSAQATDMRTPRIVPKIIYEQFIVAVISSIAFAFCSRSMAIPLNYRTMLIPPLQADANDRERGSLQADPVVGTFKTYLTTTGSLVVSLTFAYCKNLATVEDVLTGDSSSPSSSVLAAPYGVFATKQNFANGDGPDRSLAQTPNTQALSVRSVPDTNDSQWKHSCLKALEYCGLNPSQFKSSPWVNLLISKPTSQDADGESKRSRATVPWPGSLCFRKKPLEMSTTHRVGDTMLSGHEECHDPLGDARGWFAGASEREERISKRRAERMYAIPKEVNGANPVAQNLNGQSPLTMRRPSTAAAGVMYPTPPDAIQQHIGVAPSLDGAIPSPNNPPPTLAVVDADITMPTATSMPDAENDAWGGHHEQKRERSDSNAMGDSDDVMNDLGEDVFGDHDVTEDDFNFFDGPDGNDLDMDMPDLQPAPTAPAPQVMPPPLLSHPQPHKAIEPQPEVKPKPQINDSVFAKPELKHARSSLNEELNHRIKVERPDTAKRGSSPFDPATVFKRVRASLSSPTKDDYAVQPPRRKSSVFEKVEFDPKIPLINKKYEHGGAFDFSKDQRNEDSRPSAHNLSRDEYLEGQGKLKQTSKSLLGNSLIRSLTGLDTSTTHASPQRLNGHDWISEESDLESDGDDISSLSGGPVSPVKSSIKRIVVDDDVLSQATTSRETELLDDFTDEQLAIELPKLSKTESPEMLLHRLSNHDFVEIAQIITEQAATGRLEIGLEHKAESSVSLATMRSHELNIARNSLQLLHDVMPSNLGTPTAVRLKGLLEIQDLPLVGQPSRLQPRPIPGRDPNAEQLRANNLYQIPVPHLEVRRSETKLSVLPSSMSFWEGLGLSPSWGPKDISALCIFPGWKGISDHVESFLGRVKSVYESLKLGTLNNLPLSGDWDDGVLPYEVDRISTSPDATVTGRGSALVESMEVLRSSLSELKSKDKNLVIYFVYSPDNPASIIEACTAFYRCFDEYSDLLAARRESPQNELVLQLVSLDMISSTTSLVVPTPAEMIKLCIETYDRCTLFLDTEFGGPTPAPAVMLEQPPPRMIDFKLTTSPSQSLMHENSCLHVGYAESLDGRWITAAWTDNRGQRQATTSYSITRSRTPDRSVSQHKAAIIAEIWATTLTMISIWKVHWRVIITKSGVMDQREVEWWQAASTLDDKHSFTMIIMSVDTNPSLQLVPPIVKIPHTATSAFYSTPVSTPQANIVSPEQTTTPATPMRDASTLAATPTAEGAAEAEADSFLIDATDQTWGAIVGHRLCNSTTLLEVRPALASGYLIKRTGTKLEDPPVVMEVNLVHTEATPRAYEPLLREMLCYFRGLGTLARARGVVDREMDVRPWHIAAAEKGVRALHLLL
Length1502
PositionKinase
OrganismGibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831) (Bakanae and foot rot disease fungus) (Fusarium fujikuroi)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Nectriaceae> Fusarium> Fusarium fujikuroi species complex.
Aromaticity0.06
Grand average of hydropathy-0.392
Instability index50.10
Isoelectric point5.23
Molecular weight164125.65
Publications
PubMed=23825955

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32404
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     133.52|      40|     554|     386|     425|       1
---------------------------------------------------------------------------
  386-  425 (74.21/43.40)	LSGHEECHD.PL.GD.ARGWFAGASEREERISKRRAERMYAIP
  918-  960 (59.31/33.14)	LKGLLEIQDlPLvGQpSRLQPRPIPGRDPNAEQLRANNLYQIP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.60|      26|     556|      26|      51|       2
---------------------------------------------------------------------------
   26-   51 (46.34/25.97)	PPPDQSHGFQSSALEIQSSLRDQGKL
  584-  609 (50.26/28.88)	PPPLLSHPQPHKAIEPQPEVKPKPQI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     104.35|      30|     554|     118|     147|       3
---------------------------------------------------------------------------
  118-  147 (51.00/25.01)	PNNTASTSSPAEANSRNPLISPTQVAGGAL
  675-  704 (53.35/26.45)	PRRKSSVFEKVEFDPKIPLINKKYEHGGAF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     104.56|      32|     550|     190|     296|       4
---------------------------------------------------------------------------
  191-  228 (47.36/106.96)	SMAIPLNYRTMLIPPLQAdandrERGSLQADPVVgTFK
  625-  656 (57.20/ 6.14)	SLNEELNHRIKVERPDTA.....KRGSSPFDPAT.VFK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     139.92|      34|     601|     549|     583|       6
---------------------------------------------------------------------------
  277-  302 (44.55/19.61)	TKQNFANGDGPDRS................LAQTPNTQALSV
  306-  337 (28.86/11.54)	..........PDTNDSQwkhsclkaLEYCGLNPSQFKSSPWV
  549-  582 (66.51/34.78)	TEDDFNFFDGPDGNDLD........MDMPDLQPAPTAPAPQV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.07|      27|     249|     498|     542|       9
---------------------------------------------------------------------------
  498-  527 (41.19/22.96)	MPTATSmpDAENDAWGGhHEQKRERSDSNA
  753-  779 (45.88/15.52)	LDTSTT..HASPQRLNG.HDWISEESDLES
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32404 with Med13 domain of Kingdom Fungi
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