<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32393

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMDSRAAAAEAMRSAIEYWSQFVARSISQRLDTEKFENYVRLVHDQHPLPPALVADFFLRPQPSNDNSLDPRIPPYLQVLTRLGYVDAPSILKALYKYSSLHAYAQQPNAHEGRENEKENGKSDDKEKDENQQKITRWKSSYWAEEVLFYGITKSVVEGKAIRDSKTALDMTRIISKLMVLFTTAFAADMIEQLHTAQVRDEMESSRAALVALLLRMCENDILVGALVPQITDKLEQFRTEILACSDPADKKKQATNAAMDELLDSAVGLDNFVVADIPVSNTRAGLYIYLNAALIARPLLDDHALFSYMSNKYQGDIQSSAIDLILASFDILANAVFRNEGQKDAHLLRSFLINKIPILLYQLLPPGFPGTSAEFCITEALSHVDTSLFPTASLMFDESRNNNPYTESIREEFCAACVLHGLVQREHVERILGEISLSYEPSLQKHSKDKLVQDCLSDTEKIQGLVRELDKMDGNVGAVCQALVEVLRQSCHNKETMSLKVLCSQLAAKPQSLDVILLFEKLPNILEPLCQLLDNWRYEDDQEEYQPVYEEFGAVLLLVLAFTYRYNLNAVDIGIASPDSWVAKIIGRGHIGRQCNELTQRENDHLNGWIHGLFDTEAGGLGDELMSSCPPQEFYLVVAPLFQSIVVAYTHGYLNDESLKGGIEYYLWIDQKEQKSIIKILQLILLPSSISGEASTMLSSVKNLIAKPLEHALRTYQRRDPQNQDIEPLLRTLRDSIPLSRRTGGTDLNELESWTVTPPTGLSSAIKLTTQGLVHWSMHPAMNSMPTSYTHRQILAALKIMGPKRVLHVILEEIRQHTETGSASIVYDVAISLICAPDAAKDAPAVVDANGNMLPSVQRQRSLRDLLKVEAEGCRKLQKKDPALAEIVVRLHRRVEAQMIIPQPPGMLQTAEMSLNLDGDTAALGDAMAAAASGVQDNMSVDNLTLDVSMDPSGDAAMFEGFDTQDMDNFDWDDIGNAF
Length979
PositionTail
OrganismGibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831) (Bakanae and foot rot disease fungus) (Fusarium fujikuroi)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Nectriaceae> Fusarium> Fusarium fujikuroi species complex.
Aromaticity0.07
Grand average of hydropathy-0.195
Instability index44.82
Isoelectric point5.00
Molecular weight109210.21
Publications
PubMed=23825955

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32393
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.10|      13|      20|     707|     719|       1
---------------------------------------------------------------------------
  707-  719 (24.12/12.99)	KPLEHALR...TYQRR
  727-  742 (17.97/ 8.07)	EPLLRTLRdsiPLSRR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     127.41|      41|     155|     428|     469|       2
---------------------------------------------------------------------------
  428-  469 (64.60/51.79)	VERILGEISLSYE.PSLQKHSKDKLVQ..DCLSDTEkIQGLVREL
  582-  625 (62.80/45.21)	VAKIIGRGHIGRQcNELTQRENDHLNGwiHGLFDTE.AGGLGDEL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     125.88|      38|     153|     338|     376|       6
---------------------------------------------------------------------------
  301-  342 (29.12/12.32)	DDHALFSYMSNKyqgdIQssaidlilasfdI..LANAV...............FRNEGQ
  344-  381 (67.05/47.62)	DAHLLRSFLINK....IP............I..LLYQLLPPGFPGTSA...EFCITEAL
  382-  414 (29.71/16.01)	.SHVDTSLF........P............TasLMFDESRNNNPYTESireEFC.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.85|      27|     589|      64|      94|       7
---------------------------------------------------------------------------
   64-   94 (42.63/39.70)	NDNSLDPRIPPYLQVLTRlgyvDAPSILKAL
  655-  681 (48.22/33.06)	NDESLKGGIEYYLWIDQK....EQKSIIKIL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.40|      15|      32|     197|     211|       8
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  197-  211 (23.92/16.10)	QVRDEMESSRAALVA
  229-  243 (24.48/16.64)	QITDKLEQFRTEILA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     124.93|      39|     439|     471|     540|       9
---------------------------------------------------------------------------
  494-  540 (52.70/82.97)	KETMSLKVLCSQLAAKPqSLDVIlLFEKLPNileplcQLLDNWRYED
  936-  974 (72.22/34.53)	QDNMSVDNLTLDVSMDP.SGDAA.MFEGFDT......QDMDNFDWDD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32393 with Med5 domain of Kingdom Fungi
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