<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32386

Description ATP-dependent DNA helicase Q-like 4B
SequenceMVVTRGDKFAGSSLACKSMIGANKMSGSHLHEVNNSRSHFPQTNWLKVAKAFECIPSLNKFMGSNFLYSLESQKLGRDREMAARSIENIAPVTVQTLARPQIEKAWCTLINLSINNTYLRPGITPAIDNDSTSRTSSTKGSTFKVTSNADGSFCAHNHPEHSQRSVRGTAKSIDSFSSSSVGDNKIIIDKVPRVNYEVRDSVTVTNGMEMPPIKNSAQLARPVEPREVSLGEIDYDDIMEIIDVDQIAMEHCPSTCTKQPSVSKFVDIFTSRREEEQGLPPEICSNCSHGIKLGLCPEASTHVEQMKDTLLAISNEILDNTYDLGPDHVEQLHQKRLLLKKQIQQLEILIHNKERKKSQCLVSIPSHNTQYETPQTTNLEVVYGQTDSPTHVKEQGRCVTDNWNMPRDYLVSKERYDISSGSEEREQSVSEVIDVTDTESSNDKKWTSSDFPWTKNLEVYNKLVFGNHSFRPNQREIINATMSGCDVFVLMPTGGGKSLTYQLPALLCAGITLVISPLVSLIQDQIMNLLQTNISAASLSAGMEWAEQLEILQELSSEKSKYKLLYVTPEKVAKSESLLRHLEILNSRSLLARFVIDEAHCVSQWGHDFRPDYQGLGVLKQKFPNIPMLALTATATTSVKEDVVQALGLVNCVVFRQSFNRPNLWYSVVPKTNKCLEDIDKFIRENHFDECGIIYCLSRMDCEKVTEALRVFGHKAAFYHGSMDPGKRAFVQKQWSKDEINIICATVAFGMGINKPDVRFVIHHSLPKSIEGYHQECGRAGRDGQRSSCVLYYSYTDYIRVKHMISQGGLGQGQMKMGYNCKASSGRMLETNTENLLRMVSYCENEVDCRRFLQLVHLGEKFDSTNCKNTCDNCSSSKILIDKDVTVIARQLVALVKLTGERFSSAHIVEIYRGSLNQSVKRNRQDTLHLHGAGKHLTKSEASRILHYLVTEDILAEGVKKSELYGSVSSLLKVNRSKAASLLSGGQSITMRFPSTIKVSKQSKSTANPAKVPLKQTTLPMAKAAPQDSNLSGILLTALKNLRTDIVKESPDLVMAYHIFGNATLKEISKRLPRTKEELLDINGLGKAKVSKYGDRLLETIDSTINDHYKTRPGSGKRRRDENVNPNVAEDDDPDWSASQSHKKVVKNKK
Length1150
PositionUnknown
OrganismArabidopsis thaliana (Mouse-ear cress)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> malvids> Brassicales> Brassicaceae> Camelineae> Arabidopsis.
Aromaticity0.06
Grand average of hydropathy-0.429
Instability index48.35
Isoelectric point8.54
Molecular weight128576.04
Publications
PubMed=11058127
PubMed=11130712
PubMed=27862469
PubMed=12856935
PubMed=16371241
PubMed=18000056
PubMed=24265739

Function

Annotated function 3'-5' DNA helicase that may play a role in the repair of DNA (By similarity). Required to promote but not to suppress crossovers. 
GO - Cellular Component
chromosome	GO:0005694	IBA:GO_Central
cytoplasm	GO:0005737	IBA:GO_Central
nucleus	GO:0005634	IBA:GO_Central

GO - Biological Function
3'-5' DNA helicase activity	GO:0043138	IBA:GO_Central
ATP binding	GO:0005524	IEA:UniProtKB-KW
four-way junction helicase activity	GO:0009378	IBA:GO_Central
metal ion binding	GO:0046872	IEA:UniProtKB-KW
nucleic acid binding	GO:0003676	IEA:InterPro

GO - Biological Process
cellular response to cold	GO:0070417	IEUniProtKB
DNA duplex unwinding	GO:0032508	IBA:GO_Central
DNA recombination	GO:0006310	IMUniProtKB
DNA repair	GO:0006281	IBA:GO_Central
DNA unwinding involved in DNA replication	GO:0006268	IBA:GO_Central
double-strand break repair via homologous recombination	GO:0000724	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32386
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     594.42|     178|     189|     324|     512|       1
---------------------------------------------------------------------------
  204-  294 (81.84/53.12)	......................................................................................VTNGMEMP....PIKNSAQLARPVEPREVSLGEidyddimeI..IDV.DQIAMEHCPSTC.....TKQPSV.SKFVdiFT..SR.REE.EQG.............................LPPEICSncshGIK........LG
  326-  522 (277.80/247.55)	PDHVEQlhqkrlLLKKQI............QQLEILIH.NKERKKSQCLVSIPSHNTQYETpQTTNLEVVYGQTDSPTHVKEQGRCVTDNWNMPRDYlVSKERYDISSGSEEREQSVSE........V..IDVTDTESSNDKKWTSsDFpwTKNLEVYNKLV..FGNHSF.RPN.QREII...NATMSGCDVFVLMPTGGGKSLTYQLPALLCA....GITlvisplvsLI
  523-  706 (234.78/176.14)	QDQIMN......LLQTNIsaaslsagmewaEQLEILQElSSEKSKYKLLYVTPEKVAKSES.LLRHLEILNSRSLLARFVIDEAHCVSQ.WG..HDF.....RPDY.QGLGVLKQKFPN........IpmLALTATATTSVKE....DV..VQALGLVNCVV..F.RQSFnRPNlWYSVVpktNKCLEDIDKFIRENHFDECGIIYCLSRMDCE....KVT..........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.97|      21|      23|      80|     102|       2
---------------------------------------------------------------------------
   80-  102 (29.64/28.01)	EMAARSIENIApvTVQTLARPQI
  103-  123 (38.33/27.78)	EKAWCTLINLS..INNTYLRPGI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     113.88|      35|      50|     910|     945|       3
---------------------------------------------------------------------------
  910-  945 (55.85/40.20)	EIYrGSLNQSVKRNRQDTLHLHGAGKHLTKSEASRI
  963-  997 (58.03/37.07)	ELY.GSVSSLLKVNRSKAASLLSGGQSITMRFPSTI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.10|      12|      28|     868|     879|       4
---------------------------------------------------------------------------
  868-  879 (23.04/12.86)	KNTCDNCSSSKI
  897-  908 (21.05/11.14)	KLTGERFSSAHI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.58|      15|      23|    1061|    1083|       5
---------------------------------------------------------------------------
 1061- 1075 (24.88/26.92)	GNATLKEISKRLPRT
 1086- 1100 (24.70/ 8.17)	GKAKVSKYGDRLLET
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.15|      14|      22|    1014|    1027|       6
---------------------------------------------------------------------------
 1014- 1027 (23.43/16.42)	LKQTTLPMAKAAPQ
 1039- 1052 (22.72/15.69)	LKNLRTDIVKESPD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.41|      21|      30|     717|     737|       7
---------------------------------------------------------------------------
  717-  737 (39.90/28.91)	AFYHGSMDPGKRAFVQKQWSK
  748-  768 (38.51/27.63)	AFGMGINKPDVRFVIHHSLPK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32386 with Med34 domain of Kingdom Viridiplantae
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